Gene description for DHX57
Gene name DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
Gene symbol DHX57
Other names/aliases DDX57
Species Homo sapiens
 Database cross references - DHX57
ExoCarta ExoCarta_90957
Vesiclepedia VP_90957
Entrez Gene 90957
HGNC 20086
UniProt Q6P158  
 DHX57 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DHX57
Molecular Function
    DNA clamp loader activity GO:0003689 IEA
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
    RNA helicase activity GO:0003724 IEA
    helicase activity GO:0004386 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    metal ion binding GO:0046872 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    chromatin looping GO:0140588 IEA
 Experiment description of studies that identified DHX57 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DHX57
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPSA 3921
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SLFN11 91607
Affinity Capture-MS Homo sapiens
3 ZNF668  
Affinity Capture-MS Homo sapiens
4 RPSAP58 388524
Affinity Capture-MS Homo sapiens
5 PRM2  
Affinity Capture-MS Homo sapiens
6 H1FNT  
Affinity Capture-MS Homo sapiens
7 HDAC2 3066
Cross-Linking-MS (XL-MS) Homo sapiens
8 BRDT  
Affinity Capture-MS Homo sapiens
9 CLEC3A  
Affinity Capture-MS Homo sapiens
10 ZNF346  
Affinity Capture-MS Homo sapiens
11 KRTAP2-3  
Two-hybrid Homo sapiens
12 ZNF324B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TARDBP 23435
Affinity Capture-MS Homo sapiens
14 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
15 NOP56 10528
Affinity Capture-MS Homo sapiens
16 RBMY1A1  
Two-hybrid Homo sapiens
17 RPS19 6223
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RPL10 6134
Affinity Capture-MS Homo sapiens
19 RPL15 6138
Affinity Capture-MS Homo sapiens
20 CAND1 55832
Affinity Capture-MS Homo sapiens
21 FGF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 FKBP4 2288
Cross-Linking-MS (XL-MS) Homo sapiens
23 MUCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SOX2  
Affinity Capture-MS Homo sapiens
25 APOD 347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 TPT1 7178
Affinity Capture-MS Homo sapiens
27 RPL26L1 51121
Affinity Capture-MS Homo sapiens
28 USP36  
Affinity Capture-MS Homo sapiens
29 KRTAP2-4  
Two-hybrid Homo sapiens
30 EIF4ENIF1 56478
Two-hybrid Homo sapiens
31 PARK2  
Affinity Capture-MS Homo sapiens
32 RPS20 6224
Proximity Label-MS Homo sapiens
33 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 KRTAP10-6  
Two-hybrid Homo sapiens
35 KIF23 9493
Affinity Capture-MS Homo sapiens
36 ZNF524  
Affinity Capture-MS Homo sapiens
37 CHCHD2  
Affinity Capture-MS Homo sapiens
38 EIF3B 8662
Affinity Capture-MS Homo sapiens
39 COPS5 10987
Affinity Capture-MS Homo sapiens
40 FBXW7  
Affinity Capture-MS Homo sapiens
41 RPS10 6204
Affinity Capture-MS Homo sapiens
42 KRT40  
Two-hybrid Homo sapiens
43 BHLHA15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 ANOS1 3730
Affinity Capture-MS Homo sapiens
46 RPS8 6202
Affinity Capture-MS Homo sapiens
47 FBL 2091
Proximity Label-MS Homo sapiens
48 H2AFY2 55506
Affinity Capture-MS Homo sapiens
49 OBSL1 23363
Affinity Capture-MS Homo sapiens
50 RPS9 6203
Affinity Capture-MS Homo sapiens
51 ZSCAN31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 KRT31 3881
Two-hybrid Homo sapiens
53 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
54 SRP68 6730
Affinity Capture-MS Homo sapiens
55 RPS3A 6189
Affinity Capture-MS Homo sapiens
56 MECP2 4204
Affinity Capture-MS Homo sapiens
57 MYCN  
Affinity Capture-MS Homo sapiens
58 RBM42  
Affinity Capture-MS Homo sapiens
59 OASL 8638
Affinity Capture-MS Homo sapiens
60 RPS11 6205
Affinity Capture-MS Homo sapiens
61 RPL19 6143
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 RBM8A 9939
Affinity Capture-MS Homo sapiens
63 RSPO4  
Two-hybrid Homo sapiens
64 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 LIN28A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 ZDHHC17 23390
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 SRP9 6726
Affinity Capture-MS Homo sapiens
68 EIF6 3692
Proximity Label-MS Homo sapiens
69 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 DDX21 9188
Affinity Capture-MS Homo sapiens
71 LIN28B  
Affinity Capture-MS Homo sapiens
72 RPL4 6124
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CLU 1191
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 DRG1 4733
Affinity Capture-MS Homo sapiens
75 YBX2 51087
Affinity Capture-MS Homo sapiens
76 KRTAP10-1  
Two-hybrid Homo sapiens
77 NEIL1  
Affinity Capture-MS Homo sapiens
78 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
79 SRSF6 6431
Affinity Capture-MS Homo sapiens
80 PURG  
Affinity Capture-MS Homo sapiens
81 ZBTB48  
Affinity Capture-MS Homo sapiens
82 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
83 Srp72  
Affinity Capture-MS Mus musculus
84 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 BARD1 580
Affinity Capture-MS Homo sapiens
86 NTRK1 4914
Affinity Capture-MS Homo sapiens
87 FGF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 ZNF837  
Two-hybrid Homo sapiens
89 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 KRTAP10-5  
Two-hybrid Homo sapiens
91 DCTN1 1639
Proximity Label-MS Homo sapiens
92 CBX6  
Affinity Capture-MS Homo sapiens
93 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
94 DDX54 79039
Affinity Capture-MS Homo sapiens
95 LYAR 55646
Affinity Capture-MS Homo sapiens
96 RPS6 6194
Affinity Capture-MS Homo sapiens
97 HECTD1 25831
Affinity Capture-MS Homo sapiens
98 MAGEB2 4113
Affinity Capture-MS Homo sapiens
99 FGF13  
Affinity Capture-MS Homo sapiens
100 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
101 TTLL12 23170
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 KRTAP10-7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
103 RSL1D1 26156
Affinity Capture-MS Homo sapiens
104 FGFBP1 9982
Affinity Capture-MS Homo sapiens
105 EIF3G 8666
Affinity Capture-MS Homo sapiens
106 SFPQ 6421
Affinity Capture-MS Homo sapiens
107 RPL31 6160
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 ZNF473 25888
Two-hybrid Homo sapiens
109 UBE2H 7328
Affinity Capture-MS Homo sapiens
110 ABT1 29777
Affinity Capture-MS Homo sapiens
111 MRPS12  
Proximity Label-MS Homo sapiens
112 RAB7A 7879
Proximity Label-MS Homo sapiens
113 RPS2 6187
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 LRRC59 55379
Proximity Label-MS Homo sapiens
115 LMNB1 4001
Proximity Label-MS Homo sapiens
116 RC3H2  
Affinity Capture-MS Homo sapiens
117 SIRT7  
Affinity Capture-MS Homo sapiens
118 SRSF4 6429
Affinity Capture-MS Homo sapiens
119 KRTAP10-8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
120 SRSF1 6426
Affinity Capture-MS Homo sapiens
121 SURF6  
Affinity Capture-MS Homo sapiens
122 ACTBL2 345651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 Rrbp1  
Affinity Capture-MS Mus musculus
124 SRSF5 6430
Affinity Capture-MS Homo sapiens
125 RPL3 6122
Affinity Capture-MS Homo sapiens
126 KRTAP10-3  
Two-hybrid Homo sapiens
127 CBX2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
128 SPTBN1 6711
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
129 SRC 6714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 ZNF777  
Affinity Capture-MS Homo sapiens
131 PRR3  
Affinity Capture-MS Homo sapiens
132 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
133 PSPC1 55269
Affinity Capture-MS Homo sapiens
134 RPA3 6119
Proximity Label-MS Homo sapiens
135 RPS13 6207
Affinity Capture-MS Homo sapiens
136 NOL12 79159
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 PABPC5 140886
Affinity Capture-MS Homo sapiens
138 RPS14 6208
Affinity Capture-MS Homo sapiens
139 RPL27A 6157
Affinity Capture-MS Homo sapiens
140 ZNF653  
Affinity Capture-MS Homo sapiens
141 EEF1A2 1917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 SART3 9733
Affinity Capture-MS Homo sapiens
143 ZNF587  
Two-hybrid Homo sapiens
144 FNTB 2342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 DDRGK1 65992
Affinity Capture-MS Homo sapiens
146 H2AFB2  
Affinity Capture-MS Homo sapiens
147 CCDC140  
Affinity Capture-MS Homo sapiens
148 NEUROG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 RBMS2 5939
Affinity Capture-MS Homo sapiens
150 NAA10 8260
Two-hybrid Homo sapiens
151 RPS16 6217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 ZNF574  
Affinity Capture-MS Homo sapiens
153 IMMT 10989
Cross-Linking-MS (XL-MS) Homo sapiens
154 DDX50 79009
Affinity Capture-MS Homo sapiens
155 RPL37 6167
Affinity Capture-MS Homo sapiens
156 ZNF707  
Affinity Capture-MS Homo sapiens
157 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
158 ZNF689  
Affinity Capture-MS Homo sapiens
159 RPS3 6188
Affinity Capture-MS Homo sapiens
160 Akap8  
Two-hybrid Mus musculus
161 FBXL6  
Affinity Capture-MS Homo sapiens
162 RRS1 23212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 PLAGL2  
Two-hybrid Homo sapiens
164 MNDA 4332
Affinity Capture-MS Homo sapiens
165 GLMN 11146
Affinity Capture-MS Homo sapiens
166 KRTAP9-4  
Two-hybrid Homo sapiens
167 SRP19 6728
Affinity Capture-MS Homo sapiens
168 SRP72 6731
Affinity Capture-MS Homo sapiens
169 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
170 G3BP2 9908
Affinity Capture-MS Homo sapiens
171 H2AFB3  
Affinity Capture-MS Homo sapiens
172 HIST1H1B 3009
Affinity Capture-MS Homo sapiens
173 ESR1  
Affinity Capture-MS Homo sapiens
174 CEP44  
Two-hybrid Homo sapiens
175 UFL1 23376
Affinity Capture-MS Homo sapiens
176 KRR1 11103
Affinity Capture-MS Homo sapiens
177 LARP7 51574
Affinity Capture-MS Homo sapiens
178 DDX56  
Affinity Capture-MS Homo sapiens
179 RPL23A 6147
Affinity Capture-MS Homo sapiens
180 GLI4  
Affinity Capture-MS Homo sapiens
181 CIT 11113
Affinity Capture-MS Homo sapiens
182 GRSF1 2926
Proximity Label-MS Homo sapiens
183 C1QBP 708
Proximity Label-MS Homo sapiens
184 SERBP1 26135
Proximity Label-MS Homo sapiens
185 KRTAP12-3  
Two-hybrid Homo sapiens
186 GNB2L1 10399
Affinity Capture-MS Homo sapiens
187 RC3H1 149041
Affinity Capture-MS Homo sapiens
188 PCGF5  
Two-hybrid Homo sapiens
189 SESN2 83667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 ZNF467  
Affinity Capture-MS Homo sapiens
191 ZKSCAN8  
Affinity Capture-MS Homo sapiens
192 RPL17 6139
Affinity Capture-MS Homo sapiens
193 EP300 2033
Affinity Capture-MS Homo sapiens
194 KRTAP10-9  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DHX57 is involved
No pathways found





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