Gene description for GLMN
Gene name glomulin, FKBP associated protein
Gene symbol GLMN
Other names/aliases FAP
FAP48
FAP68
FKBPAP
GLML
GVM
VMGLOM
Species Homo sapiens
 Database cross references - GLMN
ExoCarta ExoCarta_11146
Vesiclepedia VP_11146
Entrez Gene 11146
HGNC 14373
MIM 601749
UniProt Q92990  
 GLMN identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for GLMN
Molecular Function
    signaling receptor binding GO:0005102 IDA
    hepatocyte growth factor receptor binding GO:0005171 IDA
    hepatocyte growth factor receptor binding GO:0005171 IPI
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 IDA
    ubiquitin-protein transferase inhibitor activity GO:0055105 IBA
    ubiquitin-protein transferase inhibitor activity GO:0055105 IGI
Biological Process
    vasculogenesis GO:0001570 IMP
    positive regulation of cytokine production GO:0001819 IMP
    neural tube closure GO:0001843 IEA
    cell surface receptor signaling pathway GO:0007166 IDA
    negative regulation of cell population proliferation GO:0008285 IDA
    regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 IMP
    positive regulation of interleukin-2 production GO:0032743 IDA
    positive regulation of interleukin-2 production GO:0032743 IMP
    epigenetic regulation of gene expression GO:0040029 IMP
    negative regulation of T cell proliferation GO:0042130 IDA
    positive regulation of phosphorylation GO:0042327 IDA
    muscle cell differentiation GO:0042692 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cullin-RING ubiquitin ligase complex GO:0031461 IPI
    Cul2-RING ubiquitin ligase complex GO:0031462 IPI
    Cul3-RING ubiquitin ligase complex GO:0031463 IPI
    Cul4A-RING E3 ubiquitin ligase complex GO:0031464 IPI
 Experiment description of studies that identified GLMN in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
7
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GLMN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CRBN  
Affinity Capture-MS Homo sapiens
2 TMEM164  
Affinity Capture-MS Homo sapiens
3 C5AR2  
Affinity Capture-MS Homo sapiens
4 TNIP1 10318
Affinity Capture-MS Homo sapiens
5 ANKLE2 23141
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SLC35G1  
Affinity Capture-MS Homo sapiens
7 PRPF8 10594
Proximity Label-MS Homo sapiens
8 HCST  
Affinity Capture-MS Homo sapiens
9 MFNG  
Affinity Capture-MS Homo sapiens
10 DYNC1I2 1781
Proximity Label-MS Homo sapiens
11 LPAR6  
Affinity Capture-MS Homo sapiens
12 PHLPP1  
Proximity Label-MS Homo sapiens
13 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 C9orf78 51759
Affinity Capture-MS Homo sapiens
15 DHX57 90957
Affinity Capture-MS Homo sapiens
16 MILR1  
Affinity Capture-MS Homo sapiens
17 KIR3DL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 AMIGO1  
Affinity Capture-MS Homo sapiens
19 CUL7 9820
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 BTBD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 NEGR1 257194
Affinity Capture-MS Homo sapiens
22 KLHDC10 23008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 HDLBP 3069
Co-fractionation Homo sapiens
24 FBXW7  
Reconstituted Complex Homo sapiens
25 IMPDH2 3615
Co-fractionation Homo sapiens
26 ZDHHC11  
Affinity Capture-MS Homo sapiens
27 ACTR1A 10121
Proximity Label-MS Homo sapiens
28 FSCN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 HCFC2  
Affinity Capture-MS Homo sapiens
30 TMEM143  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CUL1 8454
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 PSAP 5660
Co-fractionation Homo sapiens
33 GPR17 2840
Affinity Capture-MS Homo sapiens
34 KCTD6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 KLHDC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 LMAN1 3998
Proximity Label-MS Homo sapiens
37 APPBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ENPP6 133121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 VSIG1  
Affinity Capture-MS Homo sapiens
40 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 TMEM88  
Affinity Capture-MS Homo sapiens
42 GCGR  
Affinity Capture-MS Homo sapiens
43 RBX1 9978
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
44 ARRDC1 92714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 TMEM126A 84233
Affinity Capture-MS Homo sapiens
46 KCTD10 83892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 TMEM213  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TMEM55B 90809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 BTN2A3P  
Affinity Capture-MS Homo sapiens
50 PRDM16 63976
Two-hybrid Homo sapiens
51 DIRAS3  
Proximity Label-MS Homo sapiens
52 ST6GAL1 6480
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 OGT 8473
Reconstituted Complex Homo sapiens
54 IL27RA 9466
Affinity Capture-MS Homo sapiens
55 CUL2 8453
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 C16orf58 64755
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 PTGIR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 NT5E 4907
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 DTL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 VIPR2  
Affinity Capture-MS Homo sapiens
61 CYB5B 80777
Affinity Capture-MS Homo sapiens
62 EFNA4  
Affinity Capture-MS Homo sapiens
63 APLNR  
Affinity Capture-MS Homo sapiens
64 FZD10  
Affinity Capture-MS Homo sapiens
65 CUL3 8452
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
66 EFS  
Two-hybrid Homo sapiens
67 FXYD6  
Affinity Capture-MS Homo sapiens
68 HTR2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 DCAF16 54876
Affinity Capture-MS Homo sapiens
70 TBXA2R 6915
Affinity Capture-MS Homo sapiens
71 TMEM173  
Affinity Capture-MS Homo sapiens
72 FKBP5 2289
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CUL9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 TNFRSF13C  
Affinity Capture-MS Homo sapiens
75 RPA3 6119
Proximity Label-MS Homo sapiens
76 DYNC1LI1 51143
Affinity Capture-MS Homo sapiens
77 SAV1  
Proximity Label-MS Homo sapiens
78 ZSWIM6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 PPDPF  
Two-hybrid Homo sapiens
80 MET 4233
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
81 TGFA  
Affinity Capture-MS Homo sapiens
82 KIR2DL4  
Affinity Capture-MS Homo sapiens
83 MFN2 9927
Proximity Label-MS Homo sapiens
84 P2RY10  
Affinity Capture-MS Homo sapiens
85 HSPA4L 22824
Co-fractionation Homo sapiens
86 CDKN1B 1027
Co-fractionation Homo sapiens
87 IRF3 3661
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 SKP1 6500
Reconstituted Complex Homo sapiens
89 AVPR2  
Affinity Capture-MS Homo sapiens
90 NRG1 3084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 GYPA  
Affinity Capture-MS Homo sapiens
92 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
93 SNAI1  
Two-hybrid Homo sapiens
94 VASN 114990
Affinity Capture-MS Homo sapiens
95 FBXL6  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
96 C3AR1  
Affinity Capture-MS Homo sapiens
97 KLHDC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 RP2 6102
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 CDC37 11140
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
100 GFOD1  
Affinity Capture-MS Homo sapiens
101 LCK 3932
Proximity Label-MS Homo sapiens
102 HSPB1 3315
Two-hybrid Homo sapiens
103 FKBP4 2288
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
104 FKBP1A 2280
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
105 FEM1B 10116
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 CUL4B 8450
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 RNF7  
Reconstituted Complex Homo sapiens
108 ANAPC2 29882
Proximity Label-MS Homo sapiens
109 KLHL42  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 KDM1A 23028
Proximity Label-MS Homo sapiens
111 KRT8 3856
Proximity Label-MS Homo sapiens
112 EIF4B 1975
Co-fractionation Homo sapiens
113 SPPL2B 56928
Affinity Capture-MS Homo sapiens
114 MGST3 4259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 CDC37L1  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
116 CEBPB  
Co-fractionation Homo sapiens
117 PTGES3 10728
Affinity Capture-MS Homo sapiens
118 PEX5 5830
Two-hybrid Homo sapiens
119 VIPR1  
Affinity Capture-MS Homo sapiens
120 DYNC1LI2 1783
Affinity Capture-MS Homo sapiens
121 DCAF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 FXYD3 5349
Affinity Capture-MS Homo sapiens
123 BTBD9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 SCARB2 950
Affinity Capture-MS Homo sapiens
125 B3GNT8  
Affinity Capture-MS Homo sapiens
126 CUL4A 8451
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 FEM1C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 PARN  
Co-fractionation Homo sapiens
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