Gene description for IL27RA
Gene name interleukin 27 receptor, alpha
Gene symbol IL27RA
Other names/aliases CRL1
IL-27RA
IL27R
TCCR
WSX1
zcytor1
Species Homo sapiens
 Database cross references - IL27RA
ExoCarta ExoCarta_9466
Vesiclepedia VP_9466
Entrez Gene 9466
HGNC 17290
MIM 605350
UniProt Q6UWB1  
 IL27RA identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for IL27RA
Molecular Function
    transmembrane signaling receptor activity GO:0004888 TAS
    protein binding GO:0005515 IPI
    interleukin-27 receptor activity GO:0045509 IBA
Biological Process
    positive regulation of T-helper 1 type immune response GO:0002827 IEA
    negative regulation of type 2 immune response GO:0002829 IEA
    immune response GO:0006955 TAS
    cell surface receptor signaling pathway GO:0007166 TAS
    negative regulation of interleukin-17 production GO:0032700 IEA
    negative regulation of interleukin-6 production GO:0032715 IEA
    negative regulation of tumor necrosis factor production GO:0032720 IEA
    positive regulation of type II interferon production GO:0032729 IEA
    negative regulation of neuron apoptotic process GO:0043524 IMP
    regulation of isotype switching to IgG isotypes GO:0048302 IEA
    defense response to Gram-positive bacterium GO:0050830 IEA
    interleukin-27-mediated signaling pathway GO:0070106 IEA
    negative regulation of T-helper 17 type immune response GO:2000317 IEA
    negative regulation of T cell extravasation GO:2000408 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified IL27RA in sEVs
1
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for IL27RA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UFSP2 55325
Affinity Capture-MS Homo sapiens
2 DEPDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LRFN1  
Affinity Capture-MS Homo sapiens
4 B4GALT1 2683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 NRP1 8829
Affinity Capture-MS Homo sapiens
6 PLXNB2 23654
Affinity Capture-MS Homo sapiens
7 TMEM30A 55754
Affinity Capture-MS Homo sapiens
8 LMAN2L 81562
Affinity Capture-MS Homo sapiens
9 COX1 4512
Affinity Capture-MS Homo sapiens
10 FGFR1 2260
Affinity Capture-MS Homo sapiens
11 ULBP3 79465
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ILF3 3609
Affinity Capture-RNA Homo sapiens
13 CANX 821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 C1orf27 54953
Affinity Capture-MS Homo sapiens
15 MICA 100507436
Affinity Capture-MS Homo sapiens
16 GLMN 11146
Affinity Capture-MS Homo sapiens
17 ZDHHC12  
Affinity Capture-MS Homo sapiens
18 HLA-C 3107
Affinity Capture-MS Homo sapiens
19 B4GALT5 9334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 GLT8D1 55830
Affinity Capture-MS Homo sapiens
21 DEFB121  
Two-hybrid Homo sapiens
22 TMEM30B 161291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SRPR 6734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 DAD1 1603
Affinity Capture-MS Homo sapiens
25 LENG8  
Affinity Capture-MS Homo sapiens
26 TMX1 81542
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 KLRG2 346689
Affinity Capture-MS Homo sapiens
28 RHBDD3 25807
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 TNFSF18 8995
Affinity Capture-MS Homo sapiens
30 CLN6  
Affinity Capture-MS Homo sapiens
31 AP1G2 8906
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SFTPC  
Affinity Capture-MS Homo sapiens
33 PRSS8 5652
Affinity Capture-MS Homo sapiens
34 POTEE 445582
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ST3GAL4 6484
Affinity Capture-MS Homo sapiens
36 SLC38A5 92745
Affinity Capture-MS Homo sapiens
37 DNAJC18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 STAT1 6772
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
39 MINPP1 9562
Affinity Capture-MS Homo sapiens
40 HLA-DRB3 3125
Affinity Capture-MS Homo sapiens
41 GALNT15  
Two-hybrid Homo sapiens
42 JAK1 3716
Affinity Capture-Western Homo sapiens
43 GNB2 2783
Affinity Capture-MS Homo sapiens
44 SLC41A2 84102
Two-hybrid Homo sapiens
45 HLA-B 3106
Affinity Capture-MS Homo sapiens
46 CLDN2 9075
Two-hybrid Homo sapiens
47 BRICD5  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
48 FNDC3A 22862
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 KRAS 3845
Negative Genetic Homo sapiens
50 TMX4 56255
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ZDHHC6  
Affinity Capture-MS Homo sapiens
52 KIDINS220 57498
Affinity Capture-MS Homo sapiens
53 MFSD5  
Two-hybrid Homo sapiens
54 PLD6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 SCN3B  
Affinity Capture-MS Homo sapiens
56 LRP11  
Affinity Capture-MS Homo sapiens
57 YIPF6 286451
Two-hybrid Homo sapiens
58 NDC1 55706
Affinity Capture-MS Homo sapiens
59 ITM2B 9445
Affinity Capture-MS Homo sapiens
60 EBI3 10148
Affinity Capture-Western Homo sapiens
61 TUBB8 347688
Affinity Capture-MS Homo sapiens
62 TNFSF9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 CELSR2  
Affinity Capture-MS Homo sapiens
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