Gene description for LMAN2L
Gene name lectin, mannose-binding 2-like
Gene symbol LMAN2L
Other names/aliases VIPL
Species Homo sapiens
 Database cross references - LMAN2L
ExoCarta ExoCarta_81562
Vesiclepedia VP_81562
Entrez Gene 81562
HGNC 19263
MIM 609552
UniProt Q9H0V9  
 LMAN2L identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for LMAN2L
Molecular Function
    protein binding GO:0005515 IPI
    D-mannose binding GO:0005537 IBA
    D-mannose binding GO:0005537 TAS
    metal ion binding GO:0046872 IEA
Biological Process
    protein folding GO:0006457 NAS
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 IBA
    endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 TAS
    protein transport GO:0015031 IMP
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IBA
    Golgi apparatus GO:0005794 IDA
    membrane GO:0016020 TAS
    COPII-coated ER to Golgi transport vesicle GO:0030134 IBA
    COPII-coated ER to Golgi transport vesicle GO:0030134 NAS
 Experiment description of studies that identified LMAN2L in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 834
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for LMAN2L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF149 284996
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 RAMP3  
Affinity Capture-MS Homo sapiens
3 ENPP4 22875
Affinity Capture-MS Homo sapiens
4 LINGO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CACNA2D1 781
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CHRNA4  
Affinity Capture-MS Homo sapiens
7 MFAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ASGR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ECEL1  
Affinity Capture-MS Homo sapiens
10 LNPEP 4012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 Csk 12988
Affinity Capture-MS Mus musculus
12 MAL  
Two-hybrid Homo sapiens
13 TMEM106B 54664
Affinity Capture-MS Homo sapiens
14 TRDN 10345
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 TMED2 10959
Affinity Capture-MS Homo sapiens
16 RER1 11079
Affinity Capture-MS Homo sapiens
17 ABCA2 20
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 UGT8  
Affinity Capture-MS Homo sapiens
19 TMEM106A  
Affinity Capture-MS Homo sapiens
20 TSHR 7253
Affinity Capture-MS Homo sapiens
21 ZDHHC17 23390
Two-hybrid Homo sapiens
22 MRC2 9902
Affinity Capture-MS Homo sapiens
23 TMEM245 23731
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TOR1B 27348
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ACOT13  
Co-fractionation Homo sapiens
26 PTGS2 5743
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 CLU 1191
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 COPE 11316
Affinity Capture-MS Homo sapiens
29 ITGAD  
Affinity Capture-MS Homo sapiens
30 LINGO1 84894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 TSPAN3 10099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TNFSF8  
Affinity Capture-MS Homo sapiens
33 ACP2 53
Affinity Capture-MS Homo sapiens
34 CHST8 64377
Affinity Capture-MS Homo sapiens
35 CD1E  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 IL27RA 9466
Affinity Capture-MS Homo sapiens
37 CDHR4  
Affinity Capture-MS Homo sapiens
38 CD63 967
Affinity Capture-MS Homo sapiens
39 TMEM131  
Affinity Capture-MS Homo sapiens
40 ZACN  
Affinity Capture-MS Homo sapiens
41 UPK2 7379
Affinity Capture-MS Homo sapiens
42 ANO6 196527
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 SUSD1 64420
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 CANX 821
Affinity Capture-MS Homo sapiens
45 ICAM2 3384
Affinity Capture-MS Homo sapiens
46 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
47 DUOXA2  
Affinity Capture-MS Homo sapiens
48 ZDHHC12  
Affinity Capture-MS Homo sapiens
49 RNF128  
Affinity Capture-MS Homo sapiens
50 CNTNAP1 8506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 TENM3 55714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 GAA 2548
Affinity Capture-MS Homo sapiens
53 YIPF5 81555
Affinity Capture-MS Homo sapiens
54 ITGA1 3672
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 KLRB1  
Affinity Capture-MS Homo sapiens
56 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
57 LSMEM2  
Affinity Capture-MS Homo sapiens
58 PCDH10 57575
Affinity Capture-MS Homo sapiens
59 RPA3 6119
Proximity Label-MS Homo sapiens
60 COLEC12 81035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 A4GNT  
Affinity Capture-MS Homo sapiens
62 CERS6  
Affinity Capture-MS Homo sapiens
63 ENTPD2 954
Affinity Capture-MS Homo sapiens
64 KIAA0319L 79932
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 TMPRSS5  
Affinity Capture-MS Homo sapiens
66 TMEM170A  
Affinity Capture-MS Homo sapiens
67 ADAM17 6868
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 TMED10 10972
Affinity Capture-MS Homo sapiens
69 NAAA  
Affinity Capture-MS Homo sapiens
70 TTC17 55761
Affinity Capture-MS Homo sapiens
71 TXNDC15  
Affinity Capture-MS Homo sapiens
72 LDLRAD1  
Affinity Capture-MS Homo sapiens
73 CLEC2D  
Affinity Capture-MS Homo sapiens
74 B4GAT1 11041
Affinity Capture-MS Homo sapiens
75 TSPAN8 7103
Affinity Capture-MS Homo sapiens
76 HM13 81502
Affinity Capture-MS Homo sapiens
77 ITGB7 3695
Affinity Capture-MS Homo sapiens
78 SPPL2B 56928
Affinity Capture-MS Homo sapiens
79 UGT1A7 54577
Affinity Capture-MS Homo sapiens
80 ASIC4  
Affinity Capture-MS Homo sapiens
81 Homer1  
Affinity Capture-MS Mus musculus
82 PCDHB3  
Affinity Capture-MS Homo sapiens
83 ANKRD46 157567
Affinity Capture-MS Homo sapiens
84 ARSK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 HLA-C 3107
Affinity Capture-MS Homo sapiens
86 PLVAP 83483
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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