Gene description for HLA-DQA1
Gene name major histocompatibility complex, class II, DQ alpha 1
Gene symbol HLA-DQA1
Other names/aliases CD
CELIAC1
DQ-A1
GSE
HLA-DQA
Species Homo sapiens
 Database cross references - HLA-DQA1
ExoCarta ExoCarta_3117
Vesiclepedia VP_3117
Entrez Gene 3117
HGNC 4942
MIM 146880
UniProt P01909  
 HLA-DQA1 identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
 Gene ontology annotations for HLA-DQA1
Molecular Function
    protein binding GO:0005515 IPI
    MHC class II protein complex binding GO:0023026 IBA
    MHC class II receptor activity GO:0032395 NAS
    MHC class II receptor activity GO:0032395 TAS
    peptide antigen binding GO:0042605 IBA
    peptide antigen binding GO:0042605 ISS
Biological Process
    adaptive immune response GO:0002250 IEA
    peptide antigen assembly with MHC class II protein complex GO:0002503 IBA
    immune response GO:0006955 NAS
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IBA
    positive regulation of immune response GO:0050778 IBA
    positive regulation of T cell activation GO:0050870 IBA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    lysosomal membrane GO:0005765 IBA
    lysosomal membrane GO:0005765 TAS
    plasma membrane GO:0005886 NAS
    plasma membrane GO:0005886 TAS
    ER to Golgi transport vesicle membrane GO:0012507 TAS
    membrane GO:0016020 HDA
    transport vesicle membrane GO:0030658 TAS
    endocytic vesicle membrane GO:0030666 TAS
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
    late endosome membrane GO:0031902 IBA
    trans-Golgi network membrane GO:0032588 TAS
    MHC class II protein complex GO:0042613 IBA
    MHC class II protein complex GO:0042613 ISS
    lumenal side of endoplasmic reticulum membrane GO:0098553 TAS
 Experiment description of studies that identified HLA-DQA1 in sEVs
1
Experiment ID 79
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
Biophysical techniques
CD81|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
 Protein-protein interactions for HLA-DQA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DOPEY2 9980
Affinity Capture-MS Homo sapiens
2 APLP1 333
Two-hybrid Homo sapiens
3 ERN1  
Affinity Capture-MS Homo sapiens
4 CNTNAP3  
Affinity Capture-MS Homo sapiens
5 CDK7 1022
Two-hybrid Homo sapiens
6 MAN2A1 4124
Affinity Capture-MS Homo sapiens
7 CHST14 113189
Affinity Capture-MS Homo sapiens
8 ATP13A2  
Affinity Capture-MS Homo sapiens
9 HLA-B 3106
Affinity Capture-MS Homo sapiens
10 HCRT  
Affinity Capture-MS Homo sapiens
11 PISD  
Affinity Capture-MS Homo sapiens
12 SRPR 6734
Affinity Capture-MS Homo sapiens
13 ECEL1  
Affinity Capture-MS Homo sapiens
14 SPNS1 83985
Affinity Capture-MS Homo sapiens
15 POM121  
Affinity Capture-MS Homo sapiens
16 MFSD8 256471
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TMEM67 91147
Affinity Capture-MS Homo sapiens
18 ADAMTS2 9509
Affinity Capture-MS Homo sapiens
19 SLC27A6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 ST7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 POMGNT2  
Affinity Capture-MS Homo sapiens
22 SPG7  
Affinity Capture-MS Homo sapiens
23 SLC38A9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ITGA7 3679
Affinity Capture-MS Homo sapiens
25 HLA-DRB3 3125
Affinity Capture-MS Homo sapiens
26 IGSF8 93185
Affinity Capture-MS Homo sapiens
27 NR2F2  
Affinity Capture-MS Homo sapiens
28 HYAL2 8692
Affinity Capture-MS Homo sapiens
29 CUX1 1523
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 MGAT1 4245
Affinity Capture-MS Homo sapiens
31 PNPLA6 10908
Affinity Capture-MS Homo sapiens
32 TMEM201 199953
Affinity Capture-MS Homo sapiens
33 SEMA4C 54910
Affinity Capture-MS Homo sapiens
34 SCARB1 949
Affinity Capture-MS Homo sapiens
35 NLGN2 57555
Affinity Capture-MS Homo sapiens
36 UGT8  
Affinity Capture-MS Homo sapiens
37 ITFG3 83986
Affinity Capture-MS Homo sapiens
38 PON2 5445
Affinity Capture-MS Homo sapiens
39 CD14 929
Affinity Capture-MS Homo sapiens
40 SCNN1A  
Affinity Capture-MS Homo sapiens
41 SLC30A9 10463
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 TMEM259 91304
Affinity Capture-MS Homo sapiens
43 GPX8 493869
Affinity Capture-MS Homo sapiens
44 B4GALNT1  
Affinity Capture-MS Homo sapiens
45 SLC12A7 10723
Affinity Capture-MS Homo sapiens
46 UBE3C 9690
Affinity Capture-MS Homo sapiens
47 ATP6AP1 537
Affinity Capture-MS Homo sapiens
48 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 SMPD2 6610
Affinity Capture-MS Homo sapiens
50 EXTL3 2137
Affinity Capture-MS Homo sapiens
51 HLA-A 3105
Affinity Capture-MS Homo sapiens
52 EIF2AK3  
Affinity Capture-MS Homo sapiens
53 CYP2S1  
Affinity Capture-MS Homo sapiens
54 SEMA6B 10501
Affinity Capture-MS Homo sapiens
55 CD74 972
Co-localization Homo sapiens
56 RRAGB 10325
Affinity Capture-MS Homo sapiens
57 TMEM219  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 GALNT12 79695
Affinity Capture-MS Homo sapiens
59 LRIF1  
Two-hybrid Homo sapiens
60 APOL2 23780
Affinity Capture-MS Homo sapiens
61 B4GALT5 9334
Affinity Capture-MS Homo sapiens
62 MAN2A2 4122
Affinity Capture-MS Homo sapiens
63 KCNJ8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PIGT 51604
Affinity Capture-MS Homo sapiens
65 ITM2C 81618
Affinity Capture-MS Homo sapiens
66 HLA-DRB5 3127
Affinity Capture-MS Homo sapiens
67 TCTN2  
Affinity Capture-MS Homo sapiens
68 MOGS 7841
Affinity Capture-MS Homo sapiens
69 DNAJC16  
Affinity Capture-MS Homo sapiens
70 UNC119 9094
Two-hybrid Homo sapiens
71 SEMA4F  
Affinity Capture-MS Homo sapiens
72 PLXNA2 5362
Affinity Capture-MS Homo sapiens
73 ERMP1 79956
Affinity Capture-MS Homo sapiens
74 AHCTF1 25909
Affinity Capture-MS Homo sapiens
75 ACSL4 2182
Affinity Capture-MS Homo sapiens
76 TNFRSF10A 8797
Affinity Capture-MS Homo sapiens
77 HLA-DPB1 3115
Affinity Capture-MS Homo sapiens
78 SGPL1 8879
Affinity Capture-MS Homo sapiens
79 CCL17  
Affinity Capture-MS Homo sapiens
80 CANX 821
Affinity Capture-MS Homo sapiens
81 ATF6  
Affinity Capture-MS Homo sapiens
82 TMEM223  
Affinity Capture-MS Homo sapiens
83 DEFB110  
Affinity Capture-MS Homo sapiens
84 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
85 STIM1 6786
Affinity Capture-MS Homo sapiens
86 MYO19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 TMEM246 84302
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 VWC2  
Affinity Capture-MS Homo sapiens
89 GYLTL1B 120071
Affinity Capture-MS Homo sapiens
90 SLC38A10 124565
Affinity Capture-MS Homo sapiens
91 LNPEP 4012
Affinity Capture-MS Homo sapiens
92 EXT1 2131
Affinity Capture-MS Homo sapiens
93 GALT 2592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 GALNT7 51809
Affinity Capture-MS Homo sapiens
95 HLA-DQA2  
Affinity Capture-MS Homo sapiens
96 DSE 29940
Affinity Capture-MS Homo sapiens
97 ENTPD2 954
Affinity Capture-MS Homo sapiens
98 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
99 ATP6V0A1 535
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 FAM213A 84293
Affinity Capture-MS Homo sapiens
101 SH3GL2  
Two-hybrid Homo sapiens
102 SLC22A18 5002
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 PLXNA3 55558
Affinity Capture-MS Homo sapiens
104 ABCA2 20
Affinity Capture-MS Homo sapiens
105 TMEM57  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 TMEM214 54867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
108 PLXNA1 5361
Affinity Capture-MS Homo sapiens
109 IKBKG 8517
Two-hybrid Homo sapiens
110 TLE1 7088
Two-hybrid Homo sapiens
111 LMAN2L 81562
Affinity Capture-MS Homo sapiens
112 EFNB1 1947
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 LARGE 9215
Affinity Capture-MS Homo sapiens
114 ROR2 4920
Affinity Capture-MS Homo sapiens
115 FKTN  
Affinity Capture-MS Homo sapiens
116 MGAT4B 11282
Affinity Capture-MS Homo sapiens
117 EDA  
Affinity Capture-MS Homo sapiens
118 TAPBP 6892
Affinity Capture-MS Homo sapiens
119 GPRC5C 55890
Affinity Capture-MS Homo sapiens
120 GALNT18  
Affinity Capture-MS Homo sapiens
121 SLC25A4 291
Affinity Capture-MS Homo sapiens
122 FAM69A 388650
Affinity Capture-MS Homo sapiens
123 ATP2B2 491
Affinity Capture-MS Homo sapiens
124 AGPAT6 137964
Affinity Capture-MS Homo sapiens
125 TPST2 8459
Affinity Capture-MS Homo sapiens
126 ATP6V0A2 23545
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 STC2 8614
Affinity Capture-MS Homo sapiens
128 ALG11  
Affinity Capture-MS Homo sapiens
129 FKBP2 2286
Affinity Capture-MS Homo sapiens
130 SEMA4B  
Affinity Capture-MS Homo sapiens
131 HLA-C 3107
Affinity Capture-MS Homo sapiens
132 KIAA0922  
Affinity Capture-MS Homo sapiens
133 ATP2A1 487
Affinity Capture-MS Homo sapiens
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