Gene description for ADAMTS2
Gene name ADAM metallopeptidase with thrombospondin type 1 motif, 2
Gene symbol ADAMTS2
Other names/aliases ADAM-TS2
ADAMTS-2
ADAMTS-3
NPI
PC I-NP
PCI-NP
PCINP
PCPNI
PNPI
Species Homo sapiens
 Database cross references - ADAMTS2
ExoCarta ExoCarta_9509
Vesiclepedia VP_9509
Entrez Gene 9509
HGNC 218
MIM 604539
UniProt O95450  
 ADAMTS2 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ADAMTS2
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    metalloendopeptidase activity GO:0004222 TAS
    metallopeptidase activity GO:0008237 TAS
    zinc ion binding GO:0008270 IEA
Biological Process
    proteolysis GO:0006508 IBA
    spermatogenesis GO:0007283 IEA
    protein processing GO:0016485 IEA
    extracellular matrix organization GO:0030198 IBA
    collagen fibril organization GO:0030199 TAS
    lung development GO:0030324 IEA
    collagen catabolic process GO:0030574 IEA
    skin development GO:0043588 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular matrix GO:0031012 IBA
    collagen-containing extracellular matrix GO:0062023 IEA
 Experiment description of studies that identified ADAMTS2 in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ADAMTS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYZL2  
Affinity Capture-MS Homo sapiens
2 CCL3  
Affinity Capture-MS Homo sapiens
3 ADAM30 11085
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ADAM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 GPIHBP1  
Affinity Capture-MS Homo sapiens
6 PLA2G10  
Affinity Capture-MS Homo sapiens
7 MYCN  
Affinity Capture-MS Homo sapiens
8 ADAMTS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 LGI1  
Affinity Capture-MS Homo sapiens
10 LIPH 200879
Affinity Capture-MS Homo sapiens
11 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TAZ  
Affinity Capture-MS Homo sapiens
13 ADAM33 80332
Affinity Capture-MS Homo sapiens
14 GALNT10 55568
Affinity Capture-MS Homo sapiens
15 CD1B 910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MSTN  
Affinity Capture-MS Homo sapiens
17 PRG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RLN1  
Affinity Capture-MS Homo sapiens
19 CLEC12B  
Affinity Capture-MS Homo sapiens
20 KLRD1  
Affinity Capture-MS Homo sapiens
21 CLEC12A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SLURP1  
Affinity Capture-MS Homo sapiens
23 SLAMF1 6504
Affinity Capture-MS Homo sapiens
24 MMP13  
Affinity Capture-MS Homo sapiens
25 INS 3630
Affinity Capture-MS Homo sapiens
26 FUT3 2525
Affinity Capture-MS Homo sapiens
27 UGT1A5  
Affinity Capture-MS Homo sapiens
28 TCTN3  
Affinity Capture-MS Homo sapiens
29 DEFB136  
Affinity Capture-MS Homo sapiens
30 EMR4P  
Affinity Capture-MS Homo sapiens
31 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
32 IDS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 B3GNT2 10678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 SDF2L1 23753
Affinity Capture-MS Homo sapiens
35 SCGB2A2  
Affinity Capture-MS Homo sapiens
36 C1orf54  
Affinity Capture-MS Homo sapiens
37 PSCA 8000
Affinity Capture-MS Homo sapiens
38 DEFB135  
Affinity Capture-MS Homo sapiens
39 HFE  
Affinity Capture-MS Homo sapiens
40 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CLEC2B  
Affinity Capture-MS Homo sapiens
42 SUSD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 CST9L  
Affinity Capture-MS Homo sapiens
44 KLRC1  
Affinity Capture-MS Homo sapiens
45 LYPD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 DKKL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 PIK3R1 5295
Two-hybrid Homo sapiens
48 TAS1R2  
Affinity Capture-MS Homo sapiens
49 GFRA3 2676
Affinity Capture-MS Homo sapiens
50 IGFL3  
Affinity Capture-MS Homo sapiens
51 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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