Gene description for GFRA3
Gene name GDNF family receptor alpha 3
Gene symbol GFRA3
Other names/aliases GDNFR3
Species Homo sapiens
 Database cross references - GFRA3
ExoCarta ExoCarta_2676
Vesiclepedia VP_2676
Entrez Gene 2676
HGNC 4245
MIM 605710
UniProt O60609  
 GFRA3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GFRA3
Molecular Function
    signaling receptor binding GO:0005102 TAS
    protein binding GO:0005515 IPI
    axon guidance receptor activity GO:0008046 IEA
    glial cell-derived neurotrophic factor receptor activity GO:0016167 IDA
    signaling receptor activity GO:0038023 IBA
Biological Process
    neuron migration GO:0001764 IEA
    signal transduction GO:0007165 TAS
    nervous system development GO:0007399 IBA
    axon guidance GO:0007411 IEA
    peripheral nervous system development GO:0007422 TAS
    glial cell-derived neurotrophic factor receptor signaling pathway GO:0035860 IDA
    sympathetic nervous system development GO:0048485 IEA
Subcellular Localization
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    extrinsic component of membrane GO:0019898 TAS
    receptor complex GO:0043235 IBA
 Experiment description of studies that identified GFRA3 in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GFRA3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GLRB  
Affinity Capture-MS Homo sapiens
2 B3GAT3 26229
Affinity Capture-MS Homo sapiens
3 CNNM1  
Affinity Capture-MS Homo sapiens
4 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
5 ARTN  
Reconstituted Complex Homo sapiens
6 SLC12A7 10723
Affinity Capture-MS Homo sapiens
7 JMJD8  
Affinity Capture-MS Homo sapiens
8 ADAMTS2 9509
Affinity Capture-MS Homo sapiens
9 SELT 51714
Affinity Capture-MS Homo sapiens
10 STK36  
Affinity Capture-MS Homo sapiens
11 B3GALNT2 148789
Affinity Capture-MS Homo sapiens
12 FCGRT 2217
Affinity Capture-MS Homo sapiens
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