Gene description for HIST2H2AC
Gene name histone cluster 2, H2ac
Gene symbol HIST2H2AC
Other names/aliases H2A
H2A-GL101
H2A/q
H2AFQ
Species Homo sapiens
 Database cross references - HIST2H2AC
ExoCarta ExoCarta_8338
Vesiclepedia VP_8338
Entrez Gene 8338
HGNC 4738
MIM 602797
UniProt Q16777  
 HIST2H2AC identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 19837982    
Neuroblastoma cells 25944692    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for HIST2H2AC
Molecular Function
    DNA binding GO:0003677 IEA
    structural constituent of chromatin GO:0030527 IBA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    heterochromatin formation GO:0031507 IBA
Subcellular Localization
    nucleosome GO:0000786 IBA
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified HIST2H2AC in sEVs
1
Experiment ID 21
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
3
Experiment ID 138
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
4
Experiment ID 139
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
5
Experiment ID 141
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
6
Experiment ID 142
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
7
Experiment ID 143
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
8
Experiment ID 144
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
9
Experiment ID 145
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD10
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
10
Experiment ID 146
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
11
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
12
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
13
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for HIST2H2AC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Biochemical Activity Homo sapiens
2 MMP2 4313
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
4 XPC  
Affinity Capture-MS Homo sapiens
5 H2AFJ 55766
Cross-Linking-MS (XL-MS) Homo sapiens
6 SENP3 26168
Affinity Capture-MS Homo sapiens
7 RPL26L1 51121
Affinity Capture-MS Homo sapiens
8 GATAD2B 57459
Reconstituted Complex Homo sapiens
9 HDAC2 3066
Biochemical Activity Homo sapiens
10 UBE2A  
Affinity Capture-MS Homo sapiens
11 SLFN11 91607
Affinity Capture-MS Homo sapiens
12 ANP32A 8125
Reconstituted Complex Homo sapiens
13 POT1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
14 RNF4 6047
Affinity Capture-MS Homo sapiens
15 KIAA0020 9933
Affinity Capture-MS Homo sapiens
16 NRSN1  
Affinity Capture-MS Homo sapiens
17 NAA40  
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
18 DDX21 9188
Affinity Capture-MS Homo sapiens
19 TSSK6 83983
Biochemical Activity Homo sapiens
20 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
21 RPS15 6209
Affinity Capture-MS Homo sapiens
22 Usp16  
Biochemical Activity Mus musculus
23 BRCA1 672
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
24 RPS3 6188
Affinity Capture-MS Homo sapiens
25 SUPT16H 11198
Affinity Capture-MS Homo sapiens
26 IFI6  
Affinity Capture-MS Homo sapiens
27 HIST1H2BB 3018
Cross-Linking-MS (XL-MS) Homo sapiens
28 USP16  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
29 UBC 7316
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
30 HIST3H2BB 128312
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
31 MRPL50 54534
Affinity Capture-MS Homo sapiens
32 DHX57 90957
Affinity Capture-MS Homo sapiens
33 TNFSF13 8741
Affinity Capture-MS Homo sapiens
34 SUV39H1  
Affinity Capture-MS Homo sapiens
35 NCF1  
Affinity Capture-MS Homo sapiens
36 APP 351
Reconstituted Complex Homo sapiens
37 CENPA  
Affinity Capture-MS Homo sapiens
38 GOLGA7 51125
Affinity Capture-MS Homo sapiens
39 KAT7  
Biochemical Activity Homo sapiens
40 PARP2  
Affinity Capture-MS Homo sapiens
41 Aurkb  
Biochemical Activity Mus musculus
42 TOP2A 7153
Affinity Capture-MS Homo sapiens
43 RBM28 55131
Affinity Capture-MS Homo sapiens
44 LOC102724334 102724334
Cross-Linking-MS (XL-MS) Homo sapiens
45 PEMT  
Affinity Capture-MS Homo sapiens
46 MCM2 4171
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 RNF8  
Biochemical Activity Homo sapiens
48 HIST2H3A 333932
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
49 PRC1 9055
Affinity Capture-MS Homo sapiens
50 C4orf27  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
51 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
52 NPM1 4869
Reconstituted Complex Homo sapiens
53 KRI1  
Affinity Capture-MS Homo sapiens
54 SMC2 10592
Affinity Capture-Western Homo sapiens
55 HIST2H3PS2 440686
Affinity Capture-MS Homo sapiens
56 HIST1H3A 8350
Reconstituted Complex Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
57 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
58 PRKRA 8575
Affinity Capture-MS Homo sapiens
59 HMGA2 8091
Affinity Capture-MS Homo sapiens
60 RCC1 1104
Reconstituted Complex Homo sapiens
61 TMTC4  
Affinity Capture-MS Homo sapiens
62 MSL2  
Biochemical Activity Homo sapiens
63 HIST1H2AA 221613
Cross-Linking-MS (XL-MS) Homo sapiens
64 POLR2C 5432
Affinity Capture-MS Homo sapiens
65 NAP1L4 4676
Reconstituted Complex Homo sapiens
66 MECP2 4204
Co-crystal Structure Homo sapiens
67 RAB39B 116442
Affinity Capture-MS Homo sapiens
68 MYCN  
Affinity Capture-MS Homo sapiens
69 FLCN 201163
Affinity Capture-MS Homo sapiens
70 FOXP2 93986
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 USP7 7874
Biochemical Activity Homo sapiens
72 HIST2H4A 8370
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
73 MTERF3  
Affinity Capture-MS Homo sapiens
74 CTCF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 RBM19 9904
Affinity Capture-MS Homo sapiens
76 CCDC86  
Affinity Capture-MS Homo sapiens
77 LIN28A  
Affinity Capture-MS Homo sapiens
78 USP22 23326
Biochemical Activity Homo sapiens
79 MRPS30 10884
Affinity Capture-MS Homo sapiens
80 H2AFZ 3015
Affinity Capture-MS Homo sapiens
81 TRIM41 90933
Affinity Capture-MS Homo sapiens
82 EIF2AK2 5610
Biochemical Activity Homo sapiens
83 CETN2 1069
Affinity Capture-MS Homo sapiens
84 YBX1 4904
Affinity Capture-MS Homo sapiens
85 USP15 9958
Affinity Capture-Western Homo sapiens
86 RBBP7 5931
Affinity Capture-Western Homo sapiens
87 USP12 219333
Biochemical Activity Homo sapiens
88 HIST1H4A 8359
Reconstituted Complex Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Reconstituted Complex Homo sapiens
89 USP10 9100
Biochemical Activity Homo sapiens
90 CUL4B 8450
Affinity Capture-MS Homo sapiens
91 PARK2  
Affinity Capture-MS Homo sapiens
92 WHSC1 7468
Affinity Capture-MS Homo sapiens
93 LACC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 ITGAD  
Affinity Capture-MS Homo sapiens
95 LINGO1 84894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 RORB  
Affinity Capture-MS Homo sapiens
97 RBM4B  
Affinity Capture-MS Homo sapiens
98 YBX2 51087
Affinity Capture-MS Homo sapiens
99 MAPRE1 22919
Affinity Capture-MS Homo sapiens
100 NEIL1  
Affinity Capture-MS Homo sapiens
101 STX17 55014
Affinity Capture-MS Homo sapiens
102 HIST1H3E 8353
Co-purification Homo sapiens
103 Ring1  
Biochemical Activity Mus musculus
104 USP8 9101
Biochemical Activity Homo sapiens
105 CFDP1  
Affinity Capture-MS Homo sapiens
106 BLOC1S5 63915
Affinity Capture-MS Homo sapiens
107 RAG1  
Far Western Homo sapiens
108 KIAA1683  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 MAP3K13 9175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 NELFE 7936
Affinity Capture-MS Homo sapiens
111 BARD1 580
Biochemical Activity Homo sapiens
112 RNF168  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
113 NAT10 55226
Affinity Capture-MS Homo sapiens
114 DEK 7913
Affinity Capture-Western Homo sapiens
115 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
116 CRP  
Reconstituted Complex Homo sapiens
117 SSUH2  
Affinity Capture-MS Homo sapiens
118 ALDH3A1 218
Affinity Capture-MS Homo sapiens
119 PARP10 84875
Biochemical Activity Homo sapiens
120 HCN1  
Affinity Capture-MS Homo sapiens
121 RPLP0 6175
Affinity Capture-MS Homo sapiens
122 UPK1A 11045
Affinity Capture-MS Homo sapiens
123 PELP1 27043
Reconstituted Complex Homo sapiens
124 SLC2A3 6515
Affinity Capture-MS Homo sapiens
125 HDAC5 10014
Affinity Capture-MS Homo sapiens
126 PPM1G 5496
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 CEBPA  
Protein-peptide Homo sapiens
128 SETD7 80854
Affinity Capture-MS Homo sapiens
129 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
130 VSX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 HIST1H2BJ 8970
Cross-Linking-MS (XL-MS) Homo sapiens
132 IPO9 55705
Affinity Capture-MS Homo sapiens
133 C1orf189  
Affinity Capture-MS Homo sapiens
134 UBR2 23304
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
135 RSL1D1 26156
Affinity Capture-MS Homo sapiens
136 RAB37 326624
Affinity Capture-MS Homo sapiens
137 GATAD2A 54815
Reconstituted Complex Homo sapiens
138 HNRNPD 3184
Affinity Capture-MS Homo sapiens
139 MIER3 166968
Affinity Capture-MS Homo sapiens
140 MIER1  
Affinity Capture-MS Homo sapiens
141 EPDR1 54749
Affinity Capture-MS Homo sapiens
142 RPS19 6223
Affinity Capture-MS Homo sapiens
143 TAF15 8148
Reconstituted Complex Homo sapiens
144 TSPY1  
Reconstituted Complex Homo sapiens
145 RPS2 6187
Affinity Capture-MS Homo sapiens
146 HIST2H3C 126961
Affinity Capture-MS Homo sapiens
147 LMNB1 4001
Affinity Capture-MS Homo sapiens
148 TCF20  
Reconstituted Complex Homo sapiens
149 KLHL20  
Affinity Capture-MS Homo sapiens
150 SIRT7  
Reconstituted Complex Homo sapiens
151 RNF169  
Affinity Capture-Western Homo sapiens
152 HIST2H2BF 440689
Cross-Linking-MS (XL-MS) Homo sapiens
153 SCG5  
Affinity Capture-MS Homo sapiens
154 DDB2  
Biochemical Activity Homo sapiens
155 TAF1B  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
156 RAD18  
Affinity Capture-MS Homo sapiens
157 USP2  
Biochemical Activity Homo sapiens
158 RPL3 6122
Affinity Capture-MS Homo sapiens
159 EBNA1BP2 10969
Affinity Capture-MS Homo sapiens
160 NAP1L1 4673
Affinity Capture-MS Homo sapiens
161 BAP1 8314
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
162 MORF4L1  
Affinity Capture-MS Homo sapiens
163 RBBP4 5928
Affinity Capture-Western Homo sapiens
164 HIST3H3 8290
Cross-Linking-MS (XL-MS) Homo sapiens
165 HIST1H2BO 8348
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
166 AURKB 9212
Affinity Capture-Western Homo sapiens
167 HIST1H3B 8358
Affinity Capture-MS Homo sapiens
168 PRMT5 10419
Biochemical Activity Homo sapiens
169 CDYL 9425
Affinity Capture-MS Homo sapiens
170 NCAPH 23397
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
171 CTCFL  
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
172 MYC  
Affinity Capture-MS Homo sapiens
173 HIST1H2BA 255626
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
174 INO80  
Affinity Capture-Western Homo sapiens
175 GZF1  
Affinity Capture-MS Homo sapiens
176 CRAMP1L 57585
Affinity Capture-MS Homo sapiens
177 HP1BP3 50809
Affinity Capture-MS Homo sapiens
178 SART3 9733
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
179 SGIP1  
Affinity Capture-MS Homo sapiens
180 RNF2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
181 BMI1  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
182 HIST1H4I 8294
Affinity Capture-MS Homo sapiens
183 HAT1 8520
Biochemical Activity Homo sapiens
184 RPS10 6204
Affinity Capture-MS Homo sapiens
185 HMG20A  
Affinity Capture-MS Homo sapiens
186 LIG3 3980
Affinity Capture-MS Homo sapiens
187 APLF  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
188 BRD3 8019
Affinity Capture-MS Homo sapiens
189 MYSM1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
190 C9orf72  
Affinity Capture-MS Homo sapiens
191 TOMM20 9804
Affinity Capture-MS Homo sapiens
192 COPS7B 64708
Affinity Capture-MS Homo sapiens
193 H2AFX 3014
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
194 RPL19 6143
Affinity Capture-MS Homo sapiens
195 CD99L2 83692
Affinity Capture-MS Homo sapiens
196 FNDC5  
Affinity Capture-MS Homo sapiens
197 LY6D 8581
Affinity Capture-MS Homo sapiens
198 RPL13 6137
Affinity Capture-MS Homo sapiens
199 DNMT3L  
Reconstituted Complex Homo sapiens
200 UIMC1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
201 PRDM10  
Affinity Capture-MS Homo sapiens
202 TERF2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
203 SIRT6  
Affinity Capture-MS Homo sapiens
204 SMN1 6606
Affinity Capture-MS Homo sapiens
205 HMGN4  
Affinity Capture-MS Homo sapiens
206 KAT2A  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
207 TAF1A  
Reconstituted Complex Homo sapiens
208 ZMYM6NB  
Affinity Capture-MS Homo sapiens
209 USP46 64854
Biochemical Activity Homo sapiens
210 RRS1 23212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
211 ZNF346  
Affinity Capture-MS Homo sapiens
212 FOLR1 2348
Affinity Capture-MS Homo sapiens
213 STK38 11329
Biochemical Activity Homo sapiens
214 MCM5 4174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
215 HIST3H2A 92815
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
216 KAT2B  
Biochemical Activity Homo sapiens
217 MFI2 4241
Affinity Capture-MS Homo sapiens
218 RPS17 6218
Affinity Capture-MS Homo sapiens
219 ZCRB1  
Affinity Capture-MS Homo sapiens
220 PRMT7  
Biochemical Activity Homo sapiens
221 CAPZA2 830
Affinity Capture-MS Homo sapiens
222 HIST1H2BN 8341
Cross-Linking-MS (XL-MS) Homo sapiens
223 PBRM1 55193
Protein-peptide Homo sapiens
224 MORF4L2  
Affinity Capture-MS Homo sapiens
225 GON4L  
Affinity Capture-MS Homo sapiens
226 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
227 RNF20 56254
Biochemical Activity Homo sapiens
228 C16orf87 388272
Affinity Capture-MS Homo sapiens
229 C21orf33  
Affinity Capture-MS Homo sapiens
230 H2AFY 9555
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
231 FAM227B  
Affinity Capture-MS Homo sapiens
232 ESR1  
Reconstituted Complex Homo sapiens
233 PRAME  
Affinity Capture-MS Homo sapiens
234 KRR1 11103
Affinity Capture-MS Homo sapiens
235 ERCC6  
Affinity Capture-Western Homo sapiens
236 MBNL1 4154
Affinity Capture-MS Homo sapiens
237 TRIM37  
Biochemical Activity Homo sapiens
238 NCL 4691
Reconstituted Complex Homo sapiens
239 UBE2B 7320
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
240 H3F3A 3020
Cross-Linking-MS (XL-MS) Homo sapiens
241 YBX3 8531
Affinity Capture-MS Homo sapiens
242 CXXC1  
Affinity Capture-MS Homo sapiens
243 PINK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
244 H3F3C 440093
Cross-Linking-MS (XL-MS) Homo sapiens
245 TONSL  
Affinity Capture-MS Homo sapiens
246 Rnf2  
Biochemical Activity Mus musculus
247 ATXN7L3  
Biochemical Activity Homo sapiens
248 USP51  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
249 RGR  
Affinity Capture-MS Homo sapiens
250 SS18L2  
Affinity Capture-MS Homo sapiens
251 GPX7 2882
Affinity Capture-MS Homo sapiens
252 SSRP1 6749
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
253 PURA 5813
Affinity Capture-MS Homo sapiens
254 CCR1  
Affinity Capture-MS Homo sapiens
255 HORMAD2  
Affinity Capture-MS Homo sapiens
256 Uhrf1  
Affinity Capture-Western Mus musculus
257 PRKRIR  
Affinity Capture-MS Homo sapiens
258 EP300 2033
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which HIST2H2AC is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 TAS Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Amyloid fiber formation TAS Reactome
Assembly of the ORC complex at the origin of replication TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
B-WICH complex positively regulates rRNA expression TAS Reactome
Base Excision Repair TAS Reactome
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation TAS Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromatin modifications during the maternal to zygotic transition (MZT) IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization TAS Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance TAS Reactome
Cleavage of the damaged purine TAS Reactome
Cleavage of the damaged purine IEA Reactome
Cleavage of the damaged pyrimidine IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Defective pyroptosis TAS Reactome
Deposition of new CENPA-containing nucleosomes at the centromere TAS Reactome
Depurination TAS Reactome
Depurination IEA Reactome
Depyrimidination IEA Reactome
Deubiquitination TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA methylation IEA Reactome
DNA Repair TAS Reactome
DNA Repair IEA Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
Formation of the beta-catenin:TCF transactivating complex TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HATs acetylate histones IEA Reactome
HATs acetylate histones TAS Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HCMV Late Events TAS Reactome
HDACs deacetylate histones TAS Reactome
Infectious disease TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
M Phase TAS Reactome
Maternal to zygotic transition (MZT) IEA Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Meiotic synapsis IEA Reactome
Metabolism of proteins TAS Reactome
Metalloprotease DUBs TAS Reactome
Mitotic Prophase TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Negative epigenetic regulation of rRNA expression TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
NoRC negatively regulates rRNA expression TAS Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Nucleosome assembly TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Packaging Of Telomere Ends TAS Reactome
Positive epigenetic regulation of rRNA expression TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
Post-translational protein modification TAS Reactome
PRC2 methylates histones and DNA TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected purine TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected pyrimidine IEA Reactome
Regulation of endogenous retroelements TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins TAS Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TAS Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
Reproduction IEA Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases activate PKNs TAS Reactome
RMTs methylate histone arginines TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Promoter Opening TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT TAS Reactome
SIRT1 negatively regulates rRNA expression TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
TCF dependent signaling in response to WNT TAS Reactome
Telomere Maintenance TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional regulation of granulopoiesis IEA Reactome
Ub-specific processing proteases TAS Reactome
UCH proteinases TAS Reactome
Viral Infection Pathways TAS Reactome





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