Gene description for GATAD2A
Gene name GATA zinc finger domain containing 2A
Gene symbol GATAD2A
Other names/aliases p66alpha
Species Homo sapiens
 Database cross references - GATAD2A
ExoCarta ExoCarta_54815
Vesiclepedia VP_54815
Entrez Gene 54815
HGNC 29989
MIM 614997
UniProt Q86YP4  
 GATAD2A identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GATAD2A
Molecular Function
    protein binding GO:0005515 IPI
    protein-macromolecule adaptor activity GO:0030674 IDA
    sequence-specific DNA binding GO:0043565 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    chromatin remodeling GO:0006338 IDA
    regulation of cell fate specification GO:0042659 NAS
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 NAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
    regulation of stem cell differentiation GO:2000736 NAS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    NuRD complex GO:0016581 IBA
    NuRD complex GO:0016581 IDA
    NuRD complex GO:0016581 NAS
    nuclear speck GO:0016607 IEA
 Experiment description of studies that identified GATAD2A in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GATAD2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST2H2BE 8349
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
2 GATAD2B 57459
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
3 HDAC2 3066
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 KPNA1 3836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
6 ACTC1 70
Proximity Label-MS Homo sapiens
7 C9orf78 51759
Affinity Capture-MS Homo sapiens
8 NABP2  
Affinity Capture-MS Homo sapiens
9 BRD2  
Affinity Capture-MS Homo sapiens
10 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
11 KPNA2 3838
Affinity Capture-MS Homo sapiens
12 SAP30 8819
Affinity Capture-MS Homo sapiens
13 SYVN1 84447
Affinity Capture-MS Homo sapiens
14 SOX2  
Affinity Capture-MS Homo sapiens
15 CENPA  
Proximity Label-MS Homo sapiens
16 TOP2A 7153
Affinity Capture-MS Homo sapiens
17 RUVBL1 8607
Co-fractionation Homo sapiens
18 SNRNP70 6625
Co-fractionation Homo sapiens
19 Cdk2ap1  
Affinity Capture-MS Mus musculus
20 CHAF1A  
Affinity Capture-MS Homo sapiens
21 SMARCA1 6594
Affinity Capture-MS Homo sapiens
22 CDK2AP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ARHGEF19  
Affinity Capture-MS Homo sapiens
24 KRT40  
Two-hybrid Homo sapiens
25 ARID4B  
Affinity Capture-MS Homo sapiens
26 ZNF512B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 POLR1E  
Proximity Label-MS Homo sapiens
28 OBSL1 23363
Affinity Capture-MS Homo sapiens
29 SMC2 10592
Affinity Capture-MS Homo sapiens
30 BRMS1L  
Affinity Capture-MS Homo sapiens
31 CBFA2T3  
Two-hybrid Homo sapiens
32 MBD3L2  
Affinity Capture-MS Homo sapiens
33 THRSP  
Affinity Capture-MS Homo sapiens
34 HIST2H2AC 8338
Reconstituted Complex Homo sapiens
35 EED  
Affinity Capture-MS Homo sapiens
36 ZNF219  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ATG16L1 55054
Affinity Capture-MS Homo sapiens
38 PHF1  
Affinity Capture-MS Homo sapiens
39 INTS12  
Affinity Capture-MS Homo sapiens
40 CHD3 1107
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CSNK2B 1460
Affinity Capture-MS Homo sapiens
42 CPNE5 57699
Affinity Capture-MS Homo sapiens
43 MTA2 9219
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 BCL11B  
Affinity Capture-MS Homo sapiens
45 RBPJ 3516
Affinity Capture-MS Homo sapiens
46 PLCB3 5331
Affinity Capture-MS Homo sapiens
47 PSME3 10197
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 APPBP2  
Affinity Capture-MS Homo sapiens
49 H2AFZ 3015
Affinity Capture-MS Homo sapiens
50 DLD 1738
Affinity Capture-MS Homo sapiens
51 RBBP7 5931
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
52 SHPRH  
Affinity Capture-MS Homo sapiens
53 HIST1H4A 8359
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
54 SAP130  
Affinity Capture-MS Homo sapiens
55 CTBP1 1487
Proximity Label-MS Homo sapiens
56 C17orf49 124944
Affinity Capture-MS Homo sapiens
57 BTF3L4 91408
Affinity Capture-MS Homo sapiens
58 ZNF592 9640
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 PRPS2 5634
Affinity Capture-MS Homo sapiens
60 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
61 LIN52  
Affinity Capture-MS Homo sapiens
62 DEK 7913
Co-fractionation Homo sapiens
63 DPY30 84661
Affinity Capture-MS Homo sapiens
64 FYN 2534
Affinity Capture-MS Homo sapiens
65 ZBTB46  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 BPTF 2186
Affinity Capture-MS Homo sapiens
67 PARP1 142
Affinity Capture-MS Homo sapiens
68 SUZ12  
Affinity Capture-MS Homo sapiens
69 MYBL2 4605
Affinity Capture-MS Homo sapiens
70 MBD2 8932
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 CHD5 26038
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 HECTD1 25831
Affinity Capture-MS Homo sapiens
73 SUDS3  
Affinity Capture-MS Homo sapiens
74 MBD3 53615
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 KLF12  
Proximity Label-MS Homo sapiens
76 CEBPA  
Proximity Label-MS Homo sapiens
Protein-peptide Homo sapiens
77 CD3EAP  
Proximity Label-MS Homo sapiens
78 BCL11A 53335
Affinity Capture-MS Homo sapiens
79 ZBTB2 57621
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
80 HIST1H3A 8350
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
81 STMN2  
Affinity Capture-MS Homo sapiens
82 SOX6  
Proximity Label-MS Homo sapiens
83 TCF20  
Affinity Capture-MS Homo sapiens
84 SMARCA5 8467
Affinity Capture-MS Homo sapiens
85 IKZF3  
Affinity Capture-MS Homo sapiens
86 KRT32  
Two-hybrid Homo sapiens
87 NR3C1 2908
Proximity Label-MS Homo sapiens
88 BAP1 8314
Negative Genetic Homo sapiens
89 IKZF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 SIN3B  
Affinity Capture-MS Homo sapiens
91 PUS7 54517
Affinity Capture-MS Homo sapiens
92 SUGP1  
Affinity Capture-MS Homo sapiens
93 CCNL2 81669
Affinity Capture-MS Homo sapiens
94 LIN9  
Affinity Capture-MS Homo sapiens
95 Mta2 23942
Affinity Capture-MS Mus musculus
96 CHD7  
Affinity Capture-MS Homo sapiens
97 ZMYND8 23613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
99 ASF1A 25842
Proximity Label-MS Homo sapiens
100 HJURP  
Affinity Capture-MS Homo sapiens
101 ZNF687  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 Junb  
Affinity Capture-MS Mus musculus
103 SOX5 6660
Proximity Label-MS Homo sapiens
104 BEND3  
Affinity Capture-MS Homo sapiens
105 MECOM 2122
Affinity Capture-MS Homo sapiens
106 HAT1 8520
Affinity Capture-MS Homo sapiens
107 HMG20A  
Affinity Capture-MS Homo sapiens
108 NFATC2  
Affinity Capture-MS Homo sapiens
109 BRD3 8019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 RBBP4 5928
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 MBD3L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
112 DZIP3  
Affinity Capture-MS Homo sapiens
113 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
114 KRT34  
Two-hybrid Homo sapiens
115 TRPS1  
Affinity Capture-MS Homo sapiens
116 SIN3A  
Affinity Capture-MS Homo sapiens
117 SALL4  
Affinity Capture-MS Homo sapiens
118 RBM25 58517
Co-fractionation Homo sapiens
119 MTA1 9112
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 EIF1AX 1964
Affinity Capture-MS Homo sapiens
121 KLF3  
Proximity Label-MS Homo sapiens
122 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
123 HDAC1 3065
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 CHD4 1108
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 FBXO44  
Affinity Capture-Western Homo sapiens
126 SALL1 6299
Affinity Capture-MS Homo sapiens
127 DDX58 23586
Affinity Capture-RNA Homo sapiens
128 Mta1  
Affinity Capture-MS Mus musculus
129 HMGXB4 10042
Affinity Capture-MS Homo sapiens
130 FAM219A 203259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 Mbd2  
Affinity Capture-MS Mus musculus
132 EZH2  
Affinity Capture-MS Homo sapiens
133 PSMA5 5686
Affinity Capture-MS Homo sapiens
134 EIF4B 1975
Cross-Linking-MS (XL-MS) Homo sapiens
135 PINK1  
Affinity Capture-MS Homo sapiens
136 SSSCA1 10534
Affinity Capture-MS Homo sapiens
137 MTA3 57504
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 KRAS 3845
Affinity Capture-MS Homo sapiens
139 GATAD1  
Affinity Capture-MS Homo sapiens
140 MTF2  
Affinity Capture-MS Homo sapiens
141 CHAF1B  
Affinity Capture-MS Homo sapiens
142 PWWP2A  
Affinity Capture-MS Homo sapiens
143 SSRP1 6749
Affinity Capture-MS Homo sapiens
144 PHF20L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 RPA3 6119
Proximity Label-MS Homo sapiens
146 LIN37  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GATAD2A is involved
PathwayEvidenceSource
Adipogenesis IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
Gene expression (Transcription) IEA Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
HDACs deacetylate histones TAS Reactome
Infectious disease TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Intracellular signaling by second messengers TAS Reactome
PIP3 activates AKT signaling IEA Reactome
PIP3 activates AKT signaling TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
Potential therapeutics for SARS TAS Reactome
PTEN Regulation IEA Reactome
PTEN Regulation TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of PTEN gene transcription IEA Reactome
Regulation of PTEN gene transcription TAS Reactome
Regulation of TP53 Activity TAS Reactome
Regulation of TP53 Activity through Acetylation TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase I Transcription Initiation TAS Reactome
RNA Polymerase II Transcription TAS Reactome
SARS-CoV Infections TAS Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
Transcriptional regulation of brown and beige adipocyte differentiation IEA Reactome
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 IEA Reactome
Viral Infection Pathways TAS Reactome





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