Gene description for MTA3
Gene name metastasis associated 1 family, member 3
Gene symbol MTA3
Other names/aliases -
Species Homo sapiens
 Database cross references - MTA3
ExoCarta ExoCarta_57504
Vesiclepedia VP_57504
Entrez Gene 57504
HGNC 23784
MIM 609050
UniProt Q9BTC8  
 MTA3 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for MTA3
Molecular Function
    chromatin binding GO:0003682 IEA
    transcription coactivator activity GO:0003713 IBA
    transcription corepressor activity GO:0003714 IBA
    protein binding GO:0005515 IPI
    histone deacetylase binding GO:0042826 IBA
    sequence-specific DNA binding GO:0043565 IEA
    protein-containing complex binding GO:0044877 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    G2/M transition of mitotic cell cycle GO:0000086 IEA
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    chromatin remodeling GO:0006338 IDA
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IEA
    regulation of cell fate specification GO:0042659 NAS
    negative regulation of DNA-templated transcription GO:0045892 IMP
    negative regulation of DNA-templated transcription GO:0045892 NAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
    positive regulation of granulosa cell proliferation GO:1904197 IEA
    granulosa cell proliferation GO:1990739 IEA
    regulation of stem cell differentiation GO:2000736 NAS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IEA
    NuRD complex GO:0016581 IBA
    NuRD complex GO:0016581 IDA
    NuRD complex GO:0016581 NAS
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified MTA3 in sEVs
1
Experiment ID 217
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MTA3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATAD2B 57459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
2 HDAC2 3066
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 USP43  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
4 KPNA1 3836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ZNF296  
Affinity Capture-MS Homo sapiens
6 BTF3 689
Affinity Capture-MS Homo sapiens
7 C9orf78 51759
Affinity Capture-MS Homo sapiens
8 BRD2  
Affinity Capture-MS Homo sapiens
9 BUD13  
Affinity Capture-MS Homo sapiens
10 TCF19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 Cdk2ap1  
Affinity Capture-MS Mus musculus
12 GSE1 23199
Affinity Capture-MS Homo sapiens
13 CHAF1A  
Affinity Capture-MS Homo sapiens
14 SMARCA1 6594
Affinity Capture-MS Homo sapiens
15 CDK2AP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 ACRBP  
Affinity Capture-MS Homo sapiens
17 ARID4B  
Affinity Capture-MS Homo sapiens
18 ZNF512B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 BRMS1L  
Affinity Capture-MS Homo sapiens
20 MBD3L2  
Affinity Capture-MS Homo sapiens
21 THRSP  
Affinity Capture-MS Homo sapiens
22 Klc2  
Affinity Capture-MS Mus musculus
23 BRD4 23476
Affinity Capture-MS Homo sapiens
24 ZNF219  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PHF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
26 CHD3 1107
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
27 SOX5 6660
Proximity Label-MS Homo sapiens
28 MAD2L1 4085
Affinity Capture-MS Homo sapiens
29 CGB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 BCL11B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 KIF14 9928
Affinity Capture-MS Homo sapiens
32 ATP6V1G1 9550
Affinity Capture-MS Homo sapiens
33 PHF20L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 RBBP7 5931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 SHPRH  
Affinity Capture-MS Homo sapiens
36 SAP130  
Affinity Capture-MS Homo sapiens
37 RBX1 9978
Affinity Capture-Western Homo sapiens
38 CUL4B 8450
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
39 PARK2  
Affinity Capture-MS Homo sapiens
40 C17orf49 124944
Affinity Capture-MS Homo sapiens
41 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
42 LIN52  
Affinity Capture-MS Homo sapiens
43 DPY30 84661
Affinity Capture-MS Homo sapiens
44 HJURP  
Affinity Capture-MS Homo sapiens
45 GATA3  
Co-localization Homo sapiens
Co-localization Homo sapiens
46 KDM5B  
Affinity Capture-Western Homo sapiens
47 ARNT 405
Two-hybrid Homo sapiens
48 SUZ12  
Affinity Capture-MS Homo sapiens
49 MYBL2 4605
Affinity Capture-MS Homo sapiens
50 MBD2 8932
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
51 BCL6  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
52 CHD5 26038
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 SUDS3  
Affinity Capture-MS Homo sapiens
54 MRPL22  
Affinity Capture-MS Homo sapiens
55 PHF12  
Affinity Capture-MS Homo sapiens
56 MED31  
Affinity Capture-MS Homo sapiens
57 KPNA5 3841
Affinity Capture-MS Homo sapiens
58 KLF12  
Proximity Label-MS Homo sapiens
59 CEBPA  
Proximity Label-MS Homo sapiens
60 RAD21 5885
Affinity Capture-Western Homo sapiens
61 HMG20B  
Affinity Capture-MS Homo sapiens
62 BCL11A 53335
Affinity Capture-MS Homo sapiens
63 ZBTB2 57621
Affinity Capture-MS Homo sapiens
64 HIST1H3F 8968
Affinity Capture-MS Homo sapiens
65 HIST1H3A 8350
Proximity Label-MS Homo sapiens
66 CUL3 8452
Affinity Capture-MS Homo sapiens
67 SMARCAD1  
Affinity Capture-MS Homo sapiens
68 STMN2  
Affinity Capture-MS Homo sapiens
69 SOX6  
Proximity Label-MS Homo sapiens
70 NACC2  
Reconstituted Complex Homo sapiens
71 SMARCA5 8467
Affinity Capture-MS Homo sapiens
72 TFAP4 7023
Affinity Capture-MS Homo sapiens
73 BPTF 2186
Affinity Capture-MS Homo sapiens
74 METTL21B  
Affinity Capture-MS Homo sapiens
75 IKZF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 RBBP4 5928
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 SAP30 8819
Affinity Capture-MS Homo sapiens
78 JUN 3725
Affinity Capture-Western Homo sapiens
79 LIN9  
Affinity Capture-MS Homo sapiens
80 Mta2 23942
Affinity Capture-MS Mus musculus
81 ZMYND8 23613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 EED  
Affinity Capture-MS Homo sapiens
83 DDB1 1642
Affinity Capture-Western Homo sapiens
84 GAS2L2  
Affinity Capture-MS Homo sapiens
85 BEND3  
Affinity Capture-MS Homo sapiens
86 RCOR3  
Affinity Capture-MS Homo sapiens
87 HAT1 8520
Affinity Capture-MS Homo sapiens
88 NANOG  
Affinity Capture-MS Homo sapiens
89 HMG20A  
Affinity Capture-MS Homo sapiens
90 BRD3 8019
Affinity Capture-MS Homo sapiens
91 SIN3B  
Affinity Capture-MS Homo sapiens
92 EIF3D 8664
Affinity Capture-MS Homo sapiens
93 MBD3L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 MTA2 9219
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
95 GATAD2A 54815
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
96 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
97 PARP1 142
Proximity Label-MS Homo sapiens
98 TRPS1  
Affinity Capture-MS Homo sapiens
99 SIN3A  
Affinity Capture-MS Homo sapiens
100 SALL4  
Affinity Capture-MS Homo sapiens
101 MBD3 53615
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
102 MTA1 9112
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
103 KLF3  
Proximity Label-MS Homo sapiens
104 HNRNPA2B1 3181
Co-fractionation Homo sapiens
105 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
106 HDAC1 3065
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
107 CHD4 1108
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 SALL1 6299
Affinity Capture-MS Homo sapiens
109 GATAD1  
Affinity Capture-MS Homo sapiens
110 ZFPM2  
Affinity Capture-Western Homo sapiens
111 Mta1  
Affinity Capture-MS Mus musculus
112 HMGXB4 10042
Affinity Capture-MS Homo sapiens
113 FAM219A 203259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 KDM1A 23028
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
115 CDK13 8621
Co-fractionation Homo sapiens
116 Mbd2  
Affinity Capture-MS Mus musculus
117 EZH2  
Affinity Capture-MS Homo sapiens
118 TCF20  
Affinity Capture-MS Homo sapiens
119 SSSCA1 10534
Affinity Capture-MS Homo sapiens
120 CIT 11113
Affinity Capture-MS Homo sapiens
121 ZNF800  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 SERBP1 26135
Affinity Capture-MS Homo sapiens
123 AR 367
Proximity Label-MS Homo sapiens
124 MTF2  
Affinity Capture-MS Homo sapiens
125 CHAF1B  
Affinity Capture-MS Homo sapiens
126 PWWP2A  
Affinity Capture-MS Homo sapiens
127 SSRP1 6749
Affinity Capture-MS Homo sapiens
128 RCOR1  
Affinity Capture-MS Homo sapiens
129 LIN37  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MTA3 is involved
PathwayEvidenceSource
Adipogenesis IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
Gene expression (Transcription) IEA Reactome
Gene expression (Transcription) TAS Reactome
HDACs deacetylate histones TAS Reactome
Infectious disease TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Intracellular signaling by second messengers TAS Reactome
PIP3 activates AKT signaling IEA Reactome
PIP3 activates AKT signaling TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
Potential therapeutics for SARS TAS Reactome
PTEN Regulation IEA Reactome
PTEN Regulation TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of PTEN gene transcription IEA Reactome
Regulation of PTEN gene transcription TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase I Transcription Initiation TAS Reactome
SARS-CoV Infections TAS Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Transcriptional regulation of brown and beige adipocyte differentiation IEA Reactome
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 IEA Reactome
Viral Infection Pathways TAS Reactome





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