Gene description for ZMYND8
Gene name zinc finger, MYND-type containing 8
Gene symbol ZMYND8
Other names/aliases PRKCBP1
PRO2893
RACK7
Species Homo sapiens
 Database cross references - ZMYND8
ExoCarta ExoCarta_23613
Vesiclepedia VP_23613
Entrez Gene 23613
HGNC 9397
MIM 615713
UniProt Q9ULU4  
 ZMYND8 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ZMYND8
Molecular Function
    transcription corepressor activity GO:0003714 IBA
    transcription corepressor activity GO:0003714 IMP
    transcription corepressor activity GO:0003714 ISS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    protein domain specific binding GO:0019904 IDA
    methylated histone binding GO:0035064 IDA
    lysine-acetylated histone binding GO:0070577 IDA
    DNA-binding transcription factor binding GO:0140297 ISS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    double-strand break repair via homologous recombination GO:0000724 IMP
    chromatin organization GO:0006325 IEA
    nervous system development GO:0007399 IMP
    negative regulation of cell migration GO:0030336 IMP
    positive regulation of transcription elongation by RNA polymerase II GO:0032968 IMP
    positive regulation of transcription elongation by RNA polymerase II GO:0032968 IPI
    positive regulation of filopodium assembly GO:0051491 IEA
    positive regulation of dendritic spine development GO:0060999 IEA
    protein localization to chromatin GO:0071168 IMP
    modulation of excitatory postsynaptic potential GO:0098815 IEA
    regulation of postsynaptic density protein 95 clustering GO:1902897 IEA
    positive regulation of dendritic spine maintenance GO:1902952 IEA
Subcellular Localization
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IMP
    dendritic spine GO:0043197 IEA
    dendritic shaft GO:0043198 IEA
    site of DNA damage GO:0090734 IDA
 Experiment description of studies that identified ZMYND8 in sEVs
1
Experiment ID 235
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ZMYND8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHMP2A 27243
Cross-Linking-MS (XL-MS) Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
3 TRAF3IP3  
Affinity Capture-MS Homo sapiens
4 RCOR2 283248
Affinity Capture-MS Homo sapiens
5 ECT2L  
Affinity Capture-MS Homo sapiens
6 GATAD2B 57459
Affinity Capture-MS Homo sapiens
7 KPNA3 3839
Affinity Capture-MS Homo sapiens
8 HDAC2 3066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 GRAP2 9402
Affinity Capture-MS Homo sapiens
10 TANC1 85461
Affinity Capture-MS Homo sapiens
11 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
12 INTS10  
Affinity Capture-MS Homo sapiens
13 ESF1 51575
Affinity Capture-MS Homo sapiens
14 RPL15 6138
Affinity Capture-MS Homo sapiens
15 BRD2  
Affinity Capture-MS Homo sapiens
16 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 INTS1 26173
Affinity Capture-MS Homo sapiens
18 FHOD1 29109
Two-hybrid Homo sapiens
19 ATN1  
Two-hybrid Homo sapiens
20 FAXC  
Affinity Capture-MS Homo sapiens
21 SNX6 58533
Affinity Capture-MS Homo sapiens
22 APOD 347
Affinity Capture-MS Homo sapiens
23 APEX1 328
Affinity Capture-RNA Homo sapiens
24 ZNF408  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 GSE1 23199
Affinity Capture-MS Homo sapiens
26 DDX24 57062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 LONRF3  
Affinity Capture-MS Homo sapiens
28 CDK2AP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CADPS  
Affinity Capture-MS Homo sapiens
30 E2F6 1876
Affinity Capture-Western Homo sapiens
31 NPM1 4869
Affinity Capture-MS Homo sapiens
32 ZNF512B  
Affinity Capture-MS Homo sapiens
33 H2AFY2 55506
Affinity Capture-MS Homo sapiens
34 BRD4 23476
Affinity Capture-MS Homo sapiens
35 INTS6 26512
Affinity Capture-MS Homo sapiens
36 HMG20B  
Affinity Capture-MS Homo sapiens
37 PSMD5 5711
Affinity Capture-MS Homo sapiens
38 MECP2 4204
Affinity Capture-MS Homo sapiens
39 MYCN  
Affinity Capture-MS Homo sapiens
40 USP7 7874
Two-hybrid Homo sapiens
41 CSNK2B 1460
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ZFYVE9  
Two-hybrid Homo sapiens
43 RCOR3  
Affinity Capture-MS Homo sapiens
44 MTA2 9219
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 BCL11B  
Affinity Capture-MS Homo sapiens
46 RBM8A 9939
Affinity Capture-MS Homo sapiens
47 ESR1  
Affinity Capture-MS Homo sapiens
48 NOTCH2 4853
Affinity Capture-MS Homo sapiens
49 PRDM5  
Affinity Capture-MS Homo sapiens
50 BRPF1  
Affinity Capture-MS Homo sapiens
51 RBBP7 5931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CMAS 55907
Affinity Capture-MS Homo sapiens
53 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 LUZP1 7798
Affinity Capture-MS Homo sapiens
55 ZNF532  
Affinity Capture-MS Homo sapiens
56 JPH1 56704
Affinity Capture-MS Homo sapiens
57 CBX3 11335
Affinity Capture-MS Homo sapiens
58 SMARCA4 6597
Affinity Capture-Western Homo sapiens
59 ZCCHC17  
Affinity Capture-MS Homo sapiens
60 PBXIP1 57326
Two-hybrid Homo sapiens
61 CHERP 10523
Affinity Capture-MS Homo sapiens
62 PYCRL 65263
Affinity Capture-MS Homo sapiens
63 MBD2 8932
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PHF21A  
Affinity Capture-MS Homo sapiens
65 CSNK1E 1454
Two-hybrid Homo sapiens
66 CHD5 26038
Affinity Capture-MS Homo sapiens
67 Tnks2  
Affinity Capture-MS Mus musculus
68 MBD3 53615
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 H2AFY 9555
Affinity Capture-MS Homo sapiens
70 LRRC8B  
Affinity Capture-MS Homo sapiens
71 CEBPA  
Proximity Label-MS Homo sapiens
72 KDM5A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 CD3EAP  
Proximity Label-MS Homo sapiens
74 ZNF219  
Affinity Capture-MS Homo sapiens
75 BCL11A 53335
Affinity Capture-MS Homo sapiens
76 ZBTB2 57621
Affinity Capture-MS Homo sapiens
77 S100P 6286
Affinity Capture-MS Homo sapiens
78 RERE 473
Two-hybrid Homo sapiens
79 C9orf78 51759
Affinity Capture-MS Homo sapiens
80 MGA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 ADCY9 115
Affinity Capture-MS Homo sapiens
82 Tnks  
Affinity Capture-MS Mus musculus
83 TSPYL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 ARG2  
Affinity Capture-MS Homo sapiens
85 MEX3A  
Affinity Capture-RNA Homo sapiens
86 BPIFB1 92747
Affinity Capture-MS Homo sapiens
87 CD6 923
Affinity Capture-MS Homo sapiens
88 EBNA1BP2 10969
Affinity Capture-MS Homo sapiens
89 YY1 7528
Proximity Label-MS Homo sapiens
90 NUP43 348995
Proximity Label-MS Homo sapiens
91 RBBP4 5928
Affinity Capture-MS Homo sapiens
92 MEOX2  
Two-hybrid Homo sapiens
93 HECW2  
Affinity Capture-MS Homo sapiens
94 WWC1  
Affinity Capture-MS Homo sapiens
95 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 CHD3 1107
Affinity Capture-MS Homo sapiens
97 TOP1 7150
Affinity Capture-MS Homo sapiens
98 RREB1 6239
Affinity Capture-MS Homo sapiens
99 ZNF687  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 NSRP1  
Affinity Capture-MS Homo sapiens
101 BCL6  
Affinity Capture-MS Homo sapiens
102 P4HA3 283208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 HMG20A  
Affinity Capture-MS Homo sapiens
104 INTS5 80789
Affinity Capture-MS Homo sapiens
105 BRD3 8019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 ASUN  
Affinity Capture-MS Homo sapiens
107 MLKL 197259
Affinity Capture-MS Homo sapiens
108 GATAD2A 54815
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 CTNNBL1 56259
Affinity Capture-MS Homo sapiens
110 LLGL2 3993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 SPOP  
Two-hybrid Homo sapiens
112 ZNF592 9640
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 NSMCE1  
Affinity Capture-MS Homo sapiens
114 PDCD2L 84306
Affinity Capture-MS Homo sapiens
115 MTA1 9112
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 FOXJ2  
Affinity Capture-MS Homo sapiens
117 MEN1 4221
Affinity Capture-MS Homo sapiens
118 VWA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 CHD4 1108
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 TSPYL1 7259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 SUPT4H1  
Co-fractionation Homo sapiens
123 MTA3 57504
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 Rassf1  
Affinity Capture-MS Mus musculus
125 Mta1  
Affinity Capture-MS Mus musculus
126 KDM1A 23028
Affinity Capture-MS Homo sapiens
127 ZCCHC10  
Affinity Capture-MS Homo sapiens
128 CIT 11113
Affinity Capture-MS Homo sapiens
129 RPS27L 51065
Affinity Capture-MS Homo sapiens
130 KCTD17 79734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 INTS3 65123
Affinity Capture-MS Homo sapiens
132 KRAS 3845
Affinity Capture-MS Homo sapiens
133 ARAP2  
Affinity Capture-MS Homo sapiens
134 AR 367
Proximity Label-MS Homo sapiens
135 SSRP1 6749
Affinity Capture-MS Homo sapiens
136 TFAM 7019
Affinity Capture-MS Homo sapiens
137 ZBTB7A 51341
Two-hybrid Homo sapiens
138 RCOR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 KDM5C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 AGBL1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZMYND8 is involved
No pathways found





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