Gene description for INTS6
Gene name integrator complex subunit 6
Gene symbol INTS6
Other names/aliases DBI-1
DDX26
DDX26A
DICE1
HDB
INT6
Notchl2
Species Homo sapiens
 Database cross references - INTS6
ExoCarta ExoCarta_26512
Vesiclepedia VP_26512
Entrez Gene 26512
HGNC 14879
MIM 604331
UniProt Q9UL03  
 INTS6 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for INTS6
Molecular Function
    transmembrane signaling receptor activity GO:0004888 TAS
    protein binding GO:0005515 IPI
Biological Process
    snRNA processing GO:0016180 IDA
    snRNA processing GO:0016180 NAS
    regulation of transcription elongation by RNA polymerase II GO:0034243 NAS
    snRNA 3'-end processing GO:0034472 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    actin cytoskeleton GO:0015629 IDA
    integrator complex GO:0032039 IBA
    integrator complex GO:0032039 IDA
    integrator complex GO:0032039 NAS
 Experiment description of studies that identified INTS6 in sEVs
1
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for INTS6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR2G 5436
Affinity Capture-MS Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 MCM7 4176
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
5 INTS4  
Affinity Capture-MS Homo sapiens
6 PPP1CB 5500
Affinity Capture-MS Homo sapiens
7 STAT2 6773
Affinity Capture-MS Homo sapiens
8 S100A6 6277
Affinity Capture-MS Homo sapiens
9 BBS7 55212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 RPA2 6118
Affinity Capture-MS Homo sapiens
11 ANAPC15  
Affinity Capture-MS Homo sapiens
12 INTS10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 ADAM32  
Affinity Capture-MS Homo sapiens
14 C9orf78 51759
Affinity Capture-MS Homo sapiens
15 NABP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 C7orf76  
Affinity Capture-MS Homo sapiens
17 INTS1 26173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 FAXC  
Affinity Capture-MS Homo sapiens
19 ANKRD50 57182
Affinity Capture-MS Homo sapiens
20 INTS9 55756
Affinity Capture-MS Homo sapiens
21 LRP1 4035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 INTS8  
Affinity Capture-MS Homo sapiens
23 CTDSP2 10106
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
25 SCARA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 NAIF1  
Affinity Capture-MS Homo sapiens
27 DDX24 57062
Co-fractionation Homo sapiens
28 INTS2  
Affinity Capture-MS Homo sapiens
29 Ints4  
Affinity Capture-MS Mus musculus
30 INTS12  
Affinity Capture-MS Homo sapiens
31 DDX58 23586
Affinity Capture-RNA Homo sapiens
32 POLR2C 5432
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 MECP2 4204
Affinity Capture-MS Homo sapiens
34 KCNA4  
Affinity Capture-MS Homo sapiens
35 NABP1  
Affinity Capture-MS Homo sapiens
36 POLR2K  
Affinity Capture-MS Homo sapiens
37 S100A2 6273
Affinity Capture-MS Homo sapiens
38 FOXA1  
Affinity Capture-MS Homo sapiens
39 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
40 C7orf26  
Affinity Capture-MS Homo sapiens
41 CTDP1 9150
Reconstituted Complex Homo sapiens
42 SUPT5H 6829
Affinity Capture-MS Homo sapiens
43 Ppp2ca 19052
Affinity Capture-MS Mus musculus
44 PROZ 8858
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 C12orf49  
Negative Genetic Homo sapiens
46 NTRK1 4914
Affinity Capture-MS Homo sapiens
47 INTS7  
Affinity Capture-MS Homo sapiens
48 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 S100B 6285
Affinity Capture-MS Homo sapiens
50 PML 5371
Affinity Capture-MS Homo sapiens
51 Ube2i  
Two-hybrid Mus musculus
52 POLR2B 5431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
54 DDX26B  
Affinity Capture-MS Homo sapiens
55 S100P 6286
Affinity Capture-MS Homo sapiens
56 POLR2H 5437
Affinity Capture-MS Homo sapiens
57 SNRPB 6628
Cross-Linking-MS (XL-MS) Homo sapiens
58 POLR2E 5434
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 PHIP 55023
Affinity Capture-MS Homo sapiens
60 CUL3 8452
Affinity Capture-MS Homo sapiens
61 POLR2D  
Affinity Capture-MS Homo sapiens
62 POLR2A 5430
Affinity Capture-MS Homo sapiens
63 NXF1 10482
Affinity Capture-RNA Homo sapiens
64 ABTB2 25841
Affinity Capture-MS Homo sapiens
65 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 RPA3 6119
Affinity Capture-MS Homo sapiens
67 ZMYND8 23613
Affinity Capture-MS Homo sapiens
68 TOP1 7150
Affinity Capture-MS Homo sapiens
69 ZNF687  
Affinity Capture-MS Homo sapiens
70 ZNF592 9640
Affinity Capture-MS Homo sapiens
71 BMI1  
Affinity Capture-MS Homo sapiens
72 CPSF3L 54973
Affinity Capture-MS Homo sapiens
73 INTS5 80789
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 PPP2CB 5516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 ASUN  
Affinity Capture-MS Homo sapiens
76 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
77 POLR2F  
Affinity Capture-MS Homo sapiens
78 KCNA2  
Affinity Capture-MS Homo sapiens
79 POLR2J  
Affinity Capture-MS Homo sapiens
80 KNTC1 9735
Cross-Linking-MS (XL-MS) Homo sapiens
81 POLR2L 5441
Affinity Capture-MS Homo sapiens
82 RPA1 6117
Affinity Capture-MS Homo sapiens
83 VWA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 SHFM1 7979
Affinity Capture-MS Homo sapiens
85 TKT 7086
Affinity Capture-MS Homo sapiens
86 SHMT2 6472
Affinity Capture-RNA Homo sapiens
87 OLFM4 10562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 EZH1  
Affinity Capture-MS Homo sapiens
89 C20orf197  
Affinity Capture-MS Homo sapiens
90 MOV10 4343
Affinity Capture-RNA Homo sapiens
91 TBL1Y  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 Kif4  
Affinity Capture-MS Mus musculus
93 ACACA 31
Positive Genetic Homo sapiens
94 INTS3 65123
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 KRAS 3845
Negative Genetic Homo sapiens
96 SSRP1 6749
Affinity Capture-MS Homo sapiens
97 UQCR11  
Affinity Capture-MS Homo sapiens
98 CDC5L 988
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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