Gene description for UBE2B
Gene name	ubiquitin-conjugating enzyme E2B
Gene symbol	UBE2B
Other names/aliases	E2-17kDa HHR6B HR6B RAD6B UBC2
Species	Homo sapiens
Database cross references - UBE2B
ExoCarta	ExoCarta_7320
Vesiclepedia	VP_7320
Entrez Gene	7320
HGNC	12473
MIM	179095
UniProt	P63146
UBE2B identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for UBE2B

Molecular Function     ubiquitin-protein transferase activity GO:0004842 IDA     ubiquitin-protein transferase activity GO:0004842 IMP     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ubiquitin protein ligase binding GO:0031625 IPI     ubiquitin conjugating enzyme activity GO:0061631 IBA     ubiquitin conjugating enzyme activity GO:0061631 IDA Biological Process     protein polyubiquitination GO:0000209 IBA     in utero embryonic development GO:0001701 IEA     DNA repair GO:0006281 IBA     DNA repair GO:0006281 IGI     postreplication repair GO:0006301 IDA     postreplication repair GO:0006301 NAS     chromatin organization GO:0006325 IEA     ubiquitin-dependent protein catabolic process GO:0006511 IDA     ubiquitin-dependent protein catabolic process GO:0006511 NAS     apoptotic process GO:0006915 IEA     DNA damage response GO:0006974 IDA     spermatogenesis GO:0007283 TAS     sperm axoneme assembly GO:0007288 IEA     response to xenobiotic stimulus GO:0009410 IDA     response to UV GO:0009411 IGI     positive regulation of reciprocal meiotic recombination GO:0010845 IEA     protein ubiquitination GO:0016567 IDA     ectopic germ cell programmed cell death GO:0035234 IEA     negative regulation of apoptotic process GO:0043066 IEA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA     meiotic telomere clustering GO:0045141 IEA     protein stabilization GO:0050821 IMP     chiasma assembly GO:0051026 IEA     negative regulation of developmental process GO:0051093 IEA     protein autoubiquitination GO:0051865 IDA     synaptonemal complex organization GO:0070193 IEA     protein K63-linked ubiquitination GO:0070534 IDA     protein K48-linked ubiquitination GO:0070936 IDA     protein K11-linked ubiquitination GO:0070979 IDA     positive regulation of canonical Wnt signaling pathway GO:0090263 ISS     negative regulation of post-translational protein modification GO:1901874 IEA     negative regulation of reproductive process GO:2000242 IEA Subcellular Localization     chromatin GO:0000785 ISS     XY body GO:0001741 IEA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     replication fork GO:0005657 IDA     cytoplasm GO:0005737 IDA     plasma membrane GO:0005886 IEA     HULC complex GO:0033503 IBA     HULC complex GO:0033503 IDA