Gene description for H2AFX
Gene name H2A histone family, member X
Gene symbol H2AFX
Other names/aliases H2A.X
H2A/X
H2AX
Species Homo sapiens
 Database cross references - H2AFX
ExoCarta ExoCarta_3014
Vesiclepedia VP_3014
Entrez Gene 3014
HGNC 4739
MIM 601772
UniProt P16104  
 H2AFX identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for H2AFX
Molecular Function
    DNA binding GO:0003677 NAS
    damaged DNA binding GO:0003684 IEA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    structural constituent of chromatin GO:0030527 IBA
    histone binding GO:0042393 IPI
    protein heterodimerization activity GO:0046982 IEA
    chromatin-protein adaptor activity GO:0140463 IDA
Biological Process
    DNA damage checkpoint signaling GO:0000077 IDA
    double-strand break repair via homologous recombination GO:0000724 IEA
    double-strand break repair GO:0006302 NAS
    nucleosome assembly GO:0006334 NAS
    DNA damage response GO:0006974 IBA
    DNA damage response GO:0006974 IDA
    DNA damage response GO:0006974 IMP
    spermatogenesis GO:0007283 IEA
    response to ionizing radiation GO:0010212 NAS
    cerebral cortex development GO:0021987 IEA
    heterochromatin formation GO:0031507 IBA
    positive regulation of DNA repair GO:0045739 NAS
    meiotic cell cycle GO:0051321 IEA
    cellular response to gamma radiation GO:0071480 IEA
    cellular senescence GO:0090398 IEA
    protein localization to site of double-strand break GO:1990166 IDA
Subcellular Localization
    chromosome, telomeric region GO:0000781 IDA
    nucleosome GO:0000786 IBA
    condensed nuclear chromosome GO:0000794 IEA
    male germ cell nucleus GO:0001673 IEA
    XY body GO:0001741 IEA
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IMP
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    replication fork GO:0005657 IEA
    centrosome GO:0005813 IDA
    nuclear speck GO:0016607 IDA
    site of double-strand break GO:0035861 IDA
    site of double-strand break GO:0035861 IDA
    extracellular exosome GO:0070062 HDA
    site of DNA damage GO:0090734 IMP
 Experiment description of studies that identified H2AFX in sEVs
1
Experiment ID 207
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 1203
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 235
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
9
Experiment ID 236
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
10
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
11
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 224
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
13
Experiment ID 144
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
14
Experiment ID 146
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
15
Experiment ID 275
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
16
Experiment ID 274
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
17
Experiment ID 834
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 835
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
20
Experiment ID 217
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for H2AFX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST2H2BE 8349
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
2 P4HB 5034
Affinity Capture-MS Homo sapiens
3 PPP2R4 5524
Biochemical Activity Homo sapiens
4 MACROD1 28992
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ZNF346  
Affinity Capture-MS Homo sapiens
6 LDHB 3945
Affinity Capture-MS Homo sapiens
7 RIN3  
Affinity Capture-MS Homo sapiens
8 ZNF668  
Affinity Capture-MS Homo sapiens
9 DDX21 9188
Reconstituted Complex Homo sapiens
10 GLB1 2720
Affinity Capture-MS Homo sapiens
11 BRCA1 672
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
12 KIF20A 10112
Affinity Capture-MS Homo sapiens
13 UBC 7316
Affinity Capture-Western Homo sapiens
14 CSNK2A1 1457
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
15 TXNDC12 51060
Affinity Capture-MS Homo sapiens
16 PRKDC 5591
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 CENPA  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
18 DDX23 9416
Proximity Label-MS Homo sapiens
19 PELI1 57162
Affinity Capture-Western Homo sapiens
20 KIF23 9493
Affinity Capture-MS Homo sapiens
21 UBE2O 63893
Affinity Capture-Western Homo sapiens
22 MATR3 9782
Affinity Capture-MS Homo sapiens
23 RNF8  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
24 RPS9 6203
Affinity Capture-MS Homo sapiens
25 ZBTB11  
Affinity Capture-MS Homo sapiens
26 RMDN1 51115
Affinity Capture-MS Homo sapiens
27 FKBP10 60681
Affinity Capture-MS Homo sapiens
28 CPS1 1373
Affinity Capture-MS Homo sapiens
29 CKMT2  
Affinity Capture-MS Homo sapiens
30 UIMC1  
Co-localization Homo sapiens
31 KIF14 9928
Affinity Capture-MS Homo sapiens
32 CHMP4C 92421
Affinity Capture-MS Homo sapiens
33 DIS3L  
Affinity Capture-MS Homo sapiens
34 PKM 5315
Affinity Capture-MS Homo sapiens
35 MRE11A 4361
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
36 TMX1 81542
Affinity Capture-MS Homo sapiens
37 CLU 1191
Affinity Capture-MS Homo sapiens
38 RRP9 9136
Affinity Capture-MS Homo sapiens
39 YBX2 51087
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 RPL19 6143
Affinity Capture-MS Homo sapiens
41 PABPC1 26986
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 Srp72  
Affinity Capture-MS Mus musculus
43 FGF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 CBX5 23468
Affinity Capture-Western Homo sapiens
45 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
46 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 ENO1 2023
Affinity Capture-MS Homo sapiens
48 MAGEB2 4113
Affinity Capture-MS Homo sapiens
49 MAPK8 5599
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
50 SND1 27044
Affinity Capture-MS Homo sapiens
51 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
52 ANLN 54443
Affinity Capture-MS Homo sapiens
53 HMGN1  
Affinity Capture-MS Homo sapiens
54 RING1 6015
Affinity Capture-MS Homo sapiens
55 MIER3 166968
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 HSPA5 3309
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
57 AGPAT1 10554
Affinity Capture-MS Homo sapiens
58 SIRT7  
Affinity Capture-MS Homo sapiens
59 NPM3 10360
Affinity Capture-MS Homo sapiens
60 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
61 EEF1B2 1933
Affinity Capture-MS Homo sapiens
62 EIF2S2 8894
Affinity Capture-MS Homo sapiens
63 HIST1H2BO 8348
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
64 HEXA 3073
Affinity Capture-MS Homo sapiens
65 HIST1H4B 8366
Affinity Capture-MS Homo sapiens
66 HNRNPR 10236
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 SS18L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 RPA3 6119
Proximity Label-MS Homo sapiens
69 MAGEB10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 HSPA1A 3303
Affinity Capture-MS Homo sapiens
71 ZNF653  
Affinity Capture-MS Homo sapiens
72 HIST1H4I 8294
Affinity Capture-MS Homo sapiens
73 HAT1 8520
Affinity Capture-Western Homo sapiens
74 CETN2 1069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 SUPT16H 11198
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
76 BIRC5  
Affinity Capture-Western Homo sapiens
77 RPS16 6217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 PAIP1 10605
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 YBX1 4904
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 DNAH6 1768
Cross-Linking-MS (XL-MS) Homo sapiens
81 RPS27A 6233
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
82 KAT8  
Affinity Capture-Western Homo sapiens
83 HIST1H2BC 8347
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
84 WRAP53  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
85 NPAT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 HIST1H2BN 8341
Cross-Linking-MS (XL-MS) Homo sapiens
87 TKT 7086
Affinity Capture-MS Homo sapiens
88 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
89 H2AFY 9555
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 SSBP1 6742
Affinity Capture-MS Homo sapiens
91 PARP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 KRR1 11103
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 LARP7 51574
Affinity Capture-MS Homo sapiens
94 NEIL1  
Affinity Capture-MS Homo sapiens
95 HIST1H4L 8368
Affinity Capture-MS Homo sapiens
96 GAPDH 2597
Cross-Linking-MS (XL-MS) Homo sapiens
97 ALYREF 10189
Affinity Capture-MS Homo sapiens
98 SUPT6H 6830
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 RPL23A 6147
Affinity Capture-MS Homo sapiens
100 SMURF2 64750
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
101 ANXA2 302
Affinity Capture-MS Homo sapiens
102 TIAM2 26230
Two-hybrid Homo sapiens
103 MORC2  
Co-localization Homo sapiens
104 ATR  
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
105 ZNF514  
Affinity Capture-MS Homo sapiens
106 TOR1A 1861
Affinity Capture-MS Homo sapiens
107 ELAVL2 1993
Affinity Capture-MS Homo sapiens
108 RPA2 6118
Proximity Label-MS Homo sapiens
109 NACA 4666
Affinity Capture-MS Homo sapiens
110 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
111 RPL14 9045
Cross-Linking-MS (XL-MS) Homo sapiens
112 ATM 472
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
113 EIF4A1 1973
Affinity Capture-MS Homo sapiens
114 ANXA6 309
Affinity Capture-MS Homo sapiens
115 GINS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 CMBL 134147
Affinity Capture-MS Homo sapiens
117 RPS3 6188
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
119 RPS18 6222
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 SURF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 XRCC1 7515
Affinity Capture-MS Homo sapiens
122 LOC102724334 102724334
Cross-Linking-MS (XL-MS) Homo sapiens
123 S100A4 6275
Affinity Capture-MS Homo sapiens
124 PGK1 5230
Affinity Capture-MS Homo sapiens
125 B3GNT2 10678
Affinity Capture-MS Homo sapiens
126 HIST2H3A 333932
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
127 PRC1 9055
Affinity Capture-MS Homo sapiens
128 NPM1 4869
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 HIBCH 26275
Affinity Capture-MS Homo sapiens
130 KRI1  
Affinity Capture-MS Homo sapiens
131 RPLP2 6181
Affinity Capture-MS Homo sapiens
132 HIST4H4 121504
Affinity Capture-Western Homo sapiens
133 HMG20A  
Affinity Capture-MS Homo sapiens
134 MRPS7 51081
Affinity Capture-MS Homo sapiens
135 PSMB3 5691
Affinity Capture-MS Homo sapiens
136 RPS2 6187
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 YWHAB 7529
Affinity Capture-MS Homo sapiens
138 MCM6 4175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 CALM2 805
Affinity Capture-MS Homo sapiens
140 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
142 TOR1B 27348
Affinity Capture-MS Homo sapiens
143 RPL4 6124
Affinity Capture-MS Homo sapiens
144 COPG1 22820
Two-hybrid Homo sapiens
145 NBN 4683
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
146 ANXA4 307
Affinity Capture-MS Homo sapiens
147 REXO4  
Affinity Capture-MS Homo sapiens
148 LAMP1 3916
Proximity Label-MS Homo sapiens
149 NCL 4691
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
150 EYA3  
Affinity Capture-Western Homo sapiens
151 RPLP0 6175
Affinity Capture-MS Homo sapiens
152 TIMELESS  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 PPM1G 5496
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 SNRPB2 6629
Affinity Capture-MS Homo sapiens
155 HNRNPD 3184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 RPN2 6185
Affinity Capture-MS Homo sapiens
157 AIFM1 9131
Affinity Capture-MS Homo sapiens
158 TP53BP1 7158
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
Protein-peptide Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
159 MRPS35 60488
Affinity Capture-MS Homo sapiens
160 ZBTB24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
162 HSD17B10 3028
Affinity Capture-MS Homo sapiens
163 HIST3H3 8290
Cross-Linking-MS (XL-MS) Homo sapiens
164 GINS3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 HIST1H3B 8358
Affinity Capture-MS Homo sapiens
166 DMAP1 55929
Affinity Capture-Western Homo sapiens
167 C1orf174  
Affinity Capture-MS Homo sapiens
168 CRAMP1L 57585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 HNRNPAB 3182
Affinity Capture-MS Homo sapiens
170 BMI1  
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
171 LMNA 4000
Affinity Capture-MS Homo sapiens
172 RPL26 6154
Affinity Capture-MS Homo sapiens
173 HUWE1 10075
Biochemical Activity Homo sapiens
174 EEF1A1 1915
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
175 RNF43  
Affinity Capture-Western Homo sapiens
176 PRKCSH 5589
Affinity Capture-MS Homo sapiens
177 TERF2  
Two-hybrid Homo sapiens
178 PARP1 142
Co-localization Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 H3F3A 3020
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
180 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
181 C5orf64  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
182 HLTF  
Affinity Capture-MS Homo sapiens
183 CAPZA2 830
Affinity Capture-MS Homo sapiens
184 GON4L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
185 OTUB1 55611
Two-hybrid Homo sapiens
186 RPS5 6193
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
187 RAD50 10111
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
188 ESR1  
Affinity Capture-MS Homo sapiens
189 EEF1A1P5 158078
Cross-Linking-MS (XL-MS) Homo sapiens
190 ERRFI1 54206
Affinity Capture-Western Homo sapiens
191 YBX3 8531
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
192 RPL7A 6130
Affinity Capture-MS Homo sapiens
193 ANXA5 308
Affinity Capture-MS Homo sapiens
194 BRD1 23774
Reconstituted Complex Homo sapiens
195 TOPORS  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
196 ZSCAN25  
Affinity Capture-MS Homo sapiens
197 CC2D1A 54862
Co-fractionation Homo sapiens
198 NUPL2 11097
Affinity Capture-MS Homo sapiens
199 XPC  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
200 MCM7 4176
Affinity Capture-MS Homo sapiens
201 HNRNPC 3183
Affinity Capture-MS Homo sapiens
202 RPL26L1 51121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
203 SNRPE 6635
Affinity Capture-MS Homo sapiens
204 NEB 4703
Cross-Linking-MS (XL-MS) Homo sapiens
205 YWHAE 7531
Affinity Capture-MS Homo sapiens
206 LARP1B 55132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
207 HIST1H2BJ 8970
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
208 SSB 6741
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
209 FGF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 HNRNPUL2 221092
Co-fractionation Homo sapiens
211 RUVBL1 8607
Affinity Capture-Western Homo sapiens
212 TRIM28 10155
Affinity Capture-Western Homo sapiens
213 LLPH  
Affinity Capture-MS Homo sapiens
214 HIST1H2BM 8342
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
215 CTBP1 1487
Two-hybrid Homo sapiens
216 MCM2 4171
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
217 Srsf9  
Two-hybrid Mus musculus
218 KDM2A  
Co-localization Homo sapiens
219 MDC1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Protein-peptide Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
220 HIST1H2AG 8969
Affinity Capture-MS Homo sapiens
221 HIST2H3PS2 440686
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
222 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
223 PDIA6 10130
Affinity Capture-MS Homo sapiens
224 ATG16L1 55054
Affinity Capture-MS Homo sapiens
225 PRDX4 10549
Affinity Capture-MS Homo sapiens
226 CALR 811
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
227 SMARCA2 6595
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
228 YAF2  
Affinity Capture-MS Homo sapiens
229 HIST2H4A 8370
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
230 RBM19 9904
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
231 LIN28A  
Affinity Capture-MS Homo sapiens
232 PPM1D  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
233 PTGES2 80142
Affinity Capture-MS Homo sapiens
234 CXXC1  
Affinity Capture-MS Homo sapiens
235 BANP  
Affinity Capture-Western Homo sapiens
236 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
237 PSMB4 5692
Affinity Capture-MS Homo sapiens
238 ZCCHC9  
Affinity Capture-MS Homo sapiens
239 TUB  
Affinity Capture-MS Homo sapiens
240 RPS10 6204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
241 PHF14 9678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
242 BRD3 8019
Affinity Capture-MS Homo sapiens
243 BLM 641
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
244 USP11 8237
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
245 ACACA 31
Affinity Capture-MS Homo sapiens
246 BTF3 689
Affinity Capture-MS Homo sapiens
247 NGFR 4804
Two-hybrid Homo sapiens
248 RPL36 25873
Affinity Capture-MS Homo sapiens
249 ACTB 60
Two-hybrid Homo sapiens
250 RAN 5901
Affinity Capture-MS Homo sapiens
251 DHX9 1660
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
252 ENY2 56943
Co-fractionation Homo sapiens
253 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
254 H3F3C 440093
Cross-Linking-MS (XL-MS) Homo sapiens
255 HCLS1 3059
Cross-Linking-MS (XL-MS) Homo sapiens
256 IPO9 55705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
257 BARD1 580
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
258 PCBP2 5094
Affinity Capture-MS Homo sapiens
259 HNRNPDL 9987
Affinity Capture-MS Homo sapiens
260 PAIP2B  
Affinity Capture-MS Homo sapiens
261 TONSL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
262 SF3B2 10992
Affinity Capture-MS Homo sapiens
263 MIER1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
264 EFNA4  
Affinity Capture-MS Homo sapiens
265 THUMPD1 55623
Affinity Capture-MS Homo sapiens
266 MASP1 5648
Two-hybrid Homo sapiens
267 TRAF6 7189
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
268 PTEN 5728
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
269 ZFAND2A  
Affinity Capture-MS Homo sapiens
270 HIST3H2BB 128312
Cross-Linking-MS (XL-MS) Homo sapiens
271 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
272 DHX30 22907
Affinity Capture-MS Homo sapiens
273 NPSR1  
Affinity Capture-MS Homo sapiens
274 YWHAQ 10971
Affinity Capture-MS Homo sapiens
275 RAB11B 9230
Affinity Capture-MS Homo sapiens
276 PCGF1 84759
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
277 HYOU1 10525
Affinity Capture-MS Homo sapiens
278 RNF2  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
279 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
280 STK4 6789
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
281 SCMH1  
Affinity Capture-MS Homo sapiens
282 HSPA9 3313
Affinity Capture-MS Homo sapiens
283 HIST1H2BI 8346
Affinity Capture-MS Homo sapiens
284 MSN 4478
Affinity Capture-MS Homo sapiens
285 XRCC5 7520
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
286 RBBP8  
Co-localization Homo sapiens
287 HIF1A 3091
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
288 ZNF574  
Affinity Capture-MS Homo sapiens
289 APOA1BP 128240
Affinity Capture-MS Homo sapiens
290 SUMF2 25870
Affinity Capture-MS Homo sapiens
291 FOXO3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
292 SOD2 6648
Affinity Capture-MS Homo sapiens
293 SLC25A6 293
Affinity Capture-MS Homo sapiens
294 LIG3 3980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
295 AGO1  
Affinity Capture-MS Homo sapiens
296 MCM5 4174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
297 KAT2B  
Affinity Capture-Western Homo sapiens
298 LZTS3  
Affinity Capture-MS Homo sapiens
299 PLOD1 5351
Affinity Capture-MS Homo sapiens
300 CHD1L 9557
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
301 KIFAP3 22920
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
302 MKI67  
Affinity Capture-MS Homo sapiens
303 TRAP1 10131
Affinity Capture-MS Homo sapiens
304 MBNL1 4154
Affinity Capture-MS Homo sapiens
305 HDGFRP2 84717
Affinity Capture-MS Homo sapiens
306 HNRNPH3 3189
Affinity Capture-MS Homo sapiens
307 DUOX2 50506
Cross-Linking-MS (XL-MS) Homo sapiens
308 PRDX6 9588
Affinity Capture-MS Homo sapiens
309 MND1  
Co-localization Homo sapiens
310 RPL8 6132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
311 TAF1C  
Two-hybrid Homo sapiens
312 STK11 6794
Affinity Capture-MS Homo sapiens
313 SERBP1 26135
Affinity Capture-MS Homo sapiens
314 KDM2B 84678
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
315 SSRP1 6749
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
316 C16orf87 388272
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
317 UQCR11  
Affinity Capture-MS Homo sapiens
318 UBA52 7311
Cross-Linking-MS (XL-MS) Homo sapiens
319 EIF3L 51386
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
320 VPS35 55737
Affinity Capture-MS Homo sapiens
321 ZMAT1  
Affinity Capture-MS Homo sapiens
322 QARS 5859
Two-hybrid Homo sapiens
323 PAXIP1  
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
324 RPS3A 6189
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
325 CETN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
326 ERO1L 30001
Affinity Capture-MS Homo sapiens
327 POFUT1 23509
Affinity Capture-MS Homo sapiens
328 TSSK6 83983
Biochemical Activity Homo sapiens
329 TNRC18  
Cross-Linking-MS (XL-MS) Homo sapiens
330 P4HA2 8974
Affinity Capture-MS Homo sapiens
331 PBK  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
332 HSPA1L 3305
Affinity Capture-MS Homo sapiens
333 HIST1H2BB 3018
Cross-Linking-MS (XL-MS) Homo sapiens
334 PPIA 5478
Affinity Capture-MS Homo sapiens
335 CALM1 801
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
336 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
337 CFL1 1072
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
338 ILF2 3608
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
339 CTSD 1509
Affinity Capture-MS Homo sapiens
340 RPS6KA3 6197
Biochemical Activity Homo sapiens
341 CFAP45 25790
Affinity Capture-MS Homo sapiens
342 PRDX3 10935
Affinity Capture-MS Homo sapiens
343 DYRK1A 1859
Co-localization Homo sapiens
344 USP17L2  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
345 PABPC4L 132430
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
346 HIRIP3  
Affinity Capture-MS Homo sapiens
347 CYP19A1  
Affinity Capture-MS Homo sapiens
348 HMGA1 3159
Affinity Capture-MS Homo sapiens
349 CDADC1  
Cross-Linking-MS (XL-MS) Homo sapiens
350 ADARB1 104
Affinity Capture-MS Homo sapiens
351 RAD51  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
352 PRKRA 8575
Affinity Capture-MS Homo sapiens
353 GINS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
354 BCOR  
Affinity Capture-MS Homo sapiens
355 P3H1 64175
Affinity Capture-MS Homo sapiens
356 VAT1 10493
Affinity Capture-MS Homo sapiens
357 C18orf21  
Affinity Capture-MS Homo sapiens
358 CTCF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
359 CCDC86  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
360 TAF5L  
Two-hybrid Homo sapiens
361 WRN 7486
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
362 H2AFZ 3015
Co-localization Homo sapiens
363 HSP90B1 7184
Affinity Capture-MS Homo sapiens
364 A2M 2
Two-hybrid Homo sapiens
365 NONO 4841
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
366 CCT5 22948
Affinity Capture-MS Homo sapiens
367 SRSF6 6431
Affinity Capture-MS Homo sapiens
368 ATF2  
Affinity Capture-Western Homo sapiens
369 DPPA2  
Cross-Linking-MS (XL-MS) Homo sapiens
370 ZNF22  
Affinity Capture-MS Homo sapiens
371 PTCD3 55037
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
372 BRCA2 675
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
373 SMARCA4 6597
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
374 ANKHD1 54882
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
375 RNF168  
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
376 IFI16 3428
Affinity Capture-MS Homo sapiens
377 ERP29 10961
Affinity Capture-MS Homo sapiens
378 GANAB 23193
Affinity Capture-MS Homo sapiens
379 PML 5371
Affinity Capture-Western Homo sapiens
380 ELOVL5 60481
Affinity Capture-MS Homo sapiens
381 EYA1  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
382 COX4I1 1327
Proximity Label-MS Homo sapiens
383 RPL37 6167
Affinity Capture-MS Homo sapiens
384 NUMA1 4926
Affinity Capture-MS Homo sapiens
385 GAN 8139
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
386 ZNF420  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
387 HIST1H3A 8350
Co-localization Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
388 FANCD2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
389 HIST2H3C 126961
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
390 MRPL35  
Affinity Capture-MS Homo sapiens
391 HIST2H2BF 440689
Cross-Linking-MS (XL-MS) Homo sapiens
392 RLIM 51132
Affinity Capture-MS Homo sapiens
393 MCM4 4173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
394 NAP1L1 4673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
395 BAZ1B 9031
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
396 CBX2  
Co-localization Homo sapiens
397 SART1 9092
Affinity Capture-MS Homo sapiens
398 MYL6B 140465
Cross-Linking-MS (XL-MS) Homo sapiens
399 DKC1 1736
Affinity Capture-MS Homo sapiens
400 HIST1H2BA 255626
Cross-Linking-MS (XL-MS) Homo sapiens
401 MSI2 124540
Affinity Capture-MS Homo sapiens
402 KAT5  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
403 MMS22L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
404 BAZ1A 11177
Affinity Capture-Western Homo sapiens
405 TP53I3  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
406 POLR2A 5430
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
407 KIAA1522 57648
Affinity Capture-MS Homo sapiens
408 SNCA 6622
Affinity Capture-MS Homo sapiens
409 PEF1 553115
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
410 ARRB2 409
Affinity Capture-MS Homo sapiens
411 ZNF689  
Affinity Capture-MS Homo sapiens
412 KAT2A  
Affinity Capture-Western Homo sapiens
413 RAD17  
Affinity Capture-Western Homo sapiens
414 PDIA4 9601
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
415 MNDA 4332
Affinity Capture-MS Homo sapiens
416 ABHD10 55347
Affinity Capture-MS Homo sapiens
417 HNRNPA2B1 3181
Affinity Capture-MS Homo sapiens
418 PDCD6 10016
Affinity Capture-MS Homo sapiens
419 PAK1 5058
Affinity Capture-MS Homo sapiens
420 RPS15 6209
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
421 IFI6  
Affinity Capture-MS Homo sapiens
422 ELAVL1 1994
Affinity Capture-MS Homo sapiens
423 HIST1H2BD 3017
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
424 ANXA2P2 304
Affinity Capture-MS Homo sapiens
425 RPS28 6234
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
426 MCPH1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
427 PAPPA 5069
Affinity Capture-MS Homo sapiens
428 ARRB1 408
Affinity Capture-MS Homo sapiens
429 UPF1 5976
Affinity Capture-MS Homo sapiens
430 RPS6 6194
Affinity Capture-MS Homo sapiens
431 BEX1  
Affinity Capture-MS Homo sapiens
432 TSSK4 283629
Affinity Capture-MS Homo sapiens
433 XRCC6 2547
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
434 C9orf72  
Affinity Capture-MS Homo sapiens
435 WDR60 55112
Affinity Capture-MS Homo sapiens
436 ALDOA 226
Affinity Capture-MS Homo sapiens
437 DSG2 1829
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which H2AFX is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 TAS Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Amyloid fiber formation TAS Reactome
Assembly of the ORC complex at the origin of replication TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
B-WICH complex positively regulates rRNA expression TAS Reactome
Base Excision Repair TAS Reactome
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation TAS Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromatin modifications during the maternal to zygotic transition (MZT) IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
Chromosome Maintenance TAS Reactome
Cleavage of the damaged purine TAS Reactome
Cleavage of the damaged purine IEA Reactome
Cleavage of the damaged pyrimidine IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Defective pyroptosis TAS Reactome
Deposition of new CENPA-containing nucleosomes at the centromere TAS Reactome
Depurination TAS Reactome
Depurination IEA Reactome
Depyrimidination IEA Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA methylation IEA Reactome
DNA Repair TAS Reactome
DNA Repair IEA Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
Formation of the beta-catenin:TCF transactivating complex TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Homology Directed Repair TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
M Phase TAS Reactome
Maternal to zygotic transition (MZT) IEA Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Meiotic synapsis IEA Reactome
Metabolism of proteins TAS Reactome
Mitotic Prophase TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Negative epigenetic regulation of rRNA expression TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
Nonhomologous End-Joining (NHEJ) TAS Reactome
NoRC negatively regulates rRNA expression TAS Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Nucleosome assembly TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Packaging Of Telomere Ends TAS Reactome
Positive epigenetic regulation of rRNA expression TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
PRC2 methylates histones and DNA TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
Processing of DNA double-strand break ends TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected pyrimidine IEA Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Regulation of endogenous retroelements TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins TAS Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TAS Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
Replacement of protamines by nucleosomes in the male pronucleus IEA Reactome
Reproduction IEA Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases activate PKNs TAS Reactome
RMTs methylate histone arginines TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Promoter Opening TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT TAS Reactome
SIRT1 negatively regulates rRNA expression TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
TCF dependent signaling in response to WNT TAS Reactome
Telomere Maintenance TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional regulation of granulopoiesis IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here