Gene description for TIAM2
Gene name T-cell lymphoma invasion and metastasis 2
Gene symbol TIAM2
Other names/aliases STEF
TIAM-2
Species Homo sapiens
 Database cross references - TIAM2
ExoCarta ExoCarta_26230
Vesiclepedia VP_26230
Entrez Gene 26230
HGNC 11806
MIM 604709
UniProt Q8IVF5  
 TIAM2 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for TIAM2
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    GTPase activator activity GO:0005096 IEA
Biological Process
    small GTPase-mediated signal transduction GO:0007264 IBA
    positive regulation of axonogenesis GO:0050772 IBA
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    membrane GO:0016020 IBA
    lamellipodium GO:0030027 IEA
    filopodium GO:0030175 IEA
    growth cone GO:0030426 IEA
    perikaryon GO:0043204 IEA
    synapse GO:0045202 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TIAM2 in sEVs
1
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TIAM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DISC1 27185
Two-hybrid Homo sapiens
2 TNIK 23043
Two-hybrid Homo sapiens
3 RNF2  
Affinity Capture-MS Homo sapiens
4 RHOB 388
Proximity Label-MS Homo sapiens
5 UFD1L 7353
Two-hybrid Homo sapiens
6 DNM2 1785
Two-hybrid Homo sapiens
7 DDX58 23586
Affinity Capture-RNA Homo sapiens
8 TK1 7083
Two-hybrid Homo sapiens
9 SH3GL2  
Two-hybrid Homo sapiens
10 ANXA7 310
Two-hybrid Homo sapiens
11 H2AFX 3014
Two-hybrid Homo sapiens
View the network image/svg+xml



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