Gene description for MCM5
Gene name minichromosome maintenance complex component 5
Gene symbol MCM5
Other names/aliases CDC46
P1-CDC46
Species Homo sapiens
 Database cross references - MCM5
ExoCarta ExoCarta_4174
Vesiclepedia VP_4174
Entrez Gene 4174
HGNC 6948
MIM 602696
UniProt P33992  
 MCM5 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for MCM5
Molecular Function
    DNA replication origin binding GO:0003688 IEA
    DNA clamp loader activity GO:0003689 IEA
    single-stranded DNA binding GO:0003697 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    four-way junction helicase activity GO:0009378 IEA
    ATP hydrolysis activity GO:0016887 IEA
    single-stranded DNA helicase activity GO:0017116 IBA
    double-stranded DNA helicase activity GO:0036121 IEA
    3'-5' DNA helicase activity GO:0043138 IBA
    forked DNA-dependent helicase activity GO:0061749 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
    single-stranded 3'-5' DNA helicase activity GO:1990518 IEA
Biological Process
    double-strand break repair via break-induced replication GO:0000727 IBA
    DNA replication GO:0006260 TAS
    DNA unwinding involved in DNA replication GO:0006268 IDA
    DNA replication initiation GO:0006270 IBA
    chromatin remodeling GO:0006338 IEA
    regulation of DNA-templated DNA replication initiation GO:0030174 NAS
    chromatin looping GO:0140588 IEA
Subcellular Localization
    chromosome, telomeric region GO:0000781 HDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    membrane GO:0016020 HDA
    MCM complex GO:0042555 IBA
    MCM complex GO:0042555 IDA
    MCM complex GO:0042555 IPI
    CMG complex GO:0071162 IPI
    CMG complex GO:0071162 ISS
 Experiment description of studies that identified MCM5 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 498
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 1203
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
12
Experiment ID 407
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
13
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 1275
MISEV standards
Biophysical techniques
✔ Enriched markers
✔ Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 1280
MISEV standards
Biophysical techniques
✔ Enriched markers
✔ Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 405
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 417
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 411
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
26
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 413
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 211
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
30
Experiment ID 212
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
31
Experiment ID 406
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 415
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
34
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
35
Experiment ID 408
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 409
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 416
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
38
Experiment ID 410
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
39
Experiment ID 217
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MCM5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 SLFN11 91607
Affinity Capture-MS Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 MCM7 4176
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
6 RBMXL1  
Affinity Capture-MS Homo sapiens
7 ORC2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
8 MCM8 84515
Affinity Capture-MS Homo sapiens
9 SENP3 26168
Affinity Capture-MS Homo sapiens
10 KRT2 3849
Affinity Capture-MS Homo sapiens
11 SPRTN  
Affinity Capture-MS Homo sapiens
12 PPP3CA 5530
Co-fractionation Homo sapiens
13 RBPMS 11030
Two-hybrid Homo sapiens
14 HIST2H2BD  
Affinity Capture-MS Homo sapiens
15 RBMXL2  
Affinity Capture-MS Homo sapiens
16 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PRPF8 10594
Affinity Capture-MS Homo sapiens
18 CTPS2 56474
Co-fractionation Homo sapiens
19 PKM 5315
Affinity Capture-MS Homo sapiens
20 MCM9 254394
Affinity Capture-MS Homo sapiens
21 FLNB 2317
Affinity Capture-MS Homo sapiens
22 RPA2 6118
Two-hybrid Homo sapiens
23 AKAP11 11215
Affinity Capture-MS Homo sapiens
24 MCM3 4172
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
25 CAP1 10487
Co-fractionation Homo sapiens
26 DSC1 1823
Affinity Capture-MS Homo sapiens
27 DBN1 1627
Affinity Capture-MS Homo sapiens
28 HIST1H2BJ 8970
Affinity Capture-MS Homo sapiens
29 HIST1H2AC 8334
Affinity Capture-MS Homo sapiens
30 HSPA1L 3305
Affinity Capture-MS Homo sapiens
31 MORF4L2  
Co-fractionation Homo sapiens
32 MDFI  
Two-hybrid Homo sapiens
33 KIF20A 10112
Affinity Capture-MS Homo sapiens
34 HIST1H2BB 3018
Affinity Capture-MS Homo sapiens
35 C1QTNF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 HSP90AB1 3326
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
37 HIST3H2BB 128312
Affinity Capture-MS Homo sapiens
38 HNRNPCL1 343069
Affinity Capture-MS Homo sapiens
39 PLEKHA2 59339
Affinity Capture-MS Homo sapiens
40 HIST1H2BL 8340
Affinity Capture-MS Homo sapiens
41 HIST1H3A 8350
Affinity Capture-MS Homo sapiens
42 PDHB 5162
Co-fractionation Homo sapiens
43 CFL1 1072
Affinity Capture-MS Homo sapiens
44 HSPA6 3310
Affinity Capture-MS Homo sapiens
45 RABGGTB 5876
Affinity Capture-MS Homo sapiens
46 AZGP1 563
Affinity Capture-MS Homo sapiens
47 Nhsl1  
Affinity Capture-MS Mus musculus
48 H2AFV 94239
Affinity Capture-MS Homo sapiens
49 WDR36 134430
Affinity Capture-MS Homo sapiens
50 SFPQ 6421
Affinity Capture-MS Homo sapiens
51 ILF2 3608
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
52 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
53 HIST2H2AA3 8337
Affinity Capture-MS Homo sapiens
54 KIAA1429 25962
Affinity Capture-MS Homo sapiens
55 UBC 7316
Affinity Capture-MS Homo sapiens
56 TOP2A 7153
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 WDR76  
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
58 PGAM5 192111
Cross-Linking-MS (XL-MS) Homo sapiens
59 WDR41  
Affinity Capture-MS Homo sapiens
60 TUBB 203068
Affinity Capture-MS Homo sapiens
61 HIST1H2BM 8342
Affinity Capture-MS Homo sapiens
62 MCM2 4171
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Co-fractionation Homo sapiens
63 MATR3 9782
Affinity Capture-MS Homo sapiens
64 H2BFS  
Affinity Capture-MS Homo sapiens
65 SF3B1 23451
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
66 COPE 11316
Co-fractionation Homo sapiens
67 DSP 1832
Affinity Capture-MS Homo sapiens
68 LIG1 3978
Co-fractionation Homo sapiens
69 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
70 PRC1 9055
Affinity Capture-MS Homo sapiens
71 NUDT3 11165
Two-hybrid Homo sapiens
72 PPP1R7 5510
Co-fractionation Homo sapiens
73 HIST1H2AG 8969
Affinity Capture-MS Homo sapiens
74 ORC5  
Reconstituted Complex Homo sapiens
75 DDRGK1 65992
Affinity Capture-MS Homo sapiens
76 HIST3H3 8290
Affinity Capture-MS Homo sapiens
77 OBSL1 23363
Affinity Capture-MS Homo sapiens
78 MCM6 4175
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
79 MAGED2 10916
Co-fractionation Homo sapiens
80 GSPT1 2935
Co-fractionation Homo sapiens
81 ORC6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
82 HSPA7 3311
Affinity Capture-MS Homo sapiens
83 PPM1A 5494
Co-fractionation Homo sapiens
84 GINS4  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
85 ITGA4 3676
Affinity Capture-MS Homo sapiens
86 AMER1  
Affinity Capture-MS Homo sapiens
87 CKAP5 9793
Co-fractionation Homo sapiens
88 U2AF1 7307
Co-fractionation Homo sapiens
89 VCAM1 7412
Affinity Capture-MS Homo sapiens
90 FBL 2091
Affinity Capture-MS Homo sapiens
91 NAGK 55577
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 EEF1A2 1917
Affinity Capture-MS Homo sapiens
93 Mcm3 17215
Affinity Capture-MS Mus musculus
94 SNX27 81609
Affinity Capture-MS Homo sapiens
95 SPTAN1 6709
Co-fractionation Homo sapiens
96 HSPA2 3306
Affinity Capture-MS Homo sapiens
97 USP7 7874
Affinity Capture-MS Homo sapiens
98 GAPDH 2597
Affinity Capture-MS Homo sapiens
99 ATG2B 55102
Affinity Capture-MS Homo sapiens
100 SOD1 6647
Affinity Capture-MS Homo sapiens
101 EEF1A1 1915
Affinity Capture-MS Homo sapiens
102 TARBP2  
Affinity Capture-MS Homo sapiens
103 KIF14 9928
Affinity Capture-MS Homo sapiens
104 DCD 117159
Affinity Capture-MS Homo sapiens
105 HSPA8 3312
Affinity Capture-MS Homo sapiens
106 OTUD1 220213
Affinity Capture-MS Homo sapiens
107 Mcm2 17216
Affinity Capture-MS Mus musculus
108 RBMXL3  
Affinity Capture-MS Homo sapiens
109 H2AFZ 3015
Affinity Capture-MS Homo sapiens
110 ARHGEF1 9138
Co-fractionation Homo sapiens
111 PPP1CA 5499
Co-fractionation Homo sapiens
112 LMNB1 4001
Co-fractionation Homo sapiens
113 ATP5A1 498
Affinity Capture-MS Homo sapiens
114 FOXC1  
Affinity Capture-MS Homo sapiens
115 LMNA 4000
Affinity Capture-MS Homo sapiens
116 DSG1 1828
Affinity Capture-MS Homo sapiens
117 HIST1H4A 8359
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
118 DDX21 9188
Affinity Capture-MS Homo sapiens
119 CEP19  
Affinity Capture-MS Homo sapiens
120 C9orf72  
Affinity Capture-MS Homo sapiens
121 USP11 8237
Affinity Capture-MS Homo sapiens
122 PSMD4 5710
Co-fractionation Homo sapiens
123 PARK2  
Affinity Capture-MS Homo sapiens
124 HIST1H2AA 221613
Affinity Capture-MS Homo sapiens
125 PNKP 11284
Affinity Capture-MS Homo sapiens
126 SBSN 374897
Affinity Capture-MS Homo sapiens
127 RALA 5898
Affinity Capture-MS Homo sapiens
128 TUBB2B 347733
Affinity Capture-MS Homo sapiens
129 POLA2  
Affinity Capture-MS Homo sapiens
130 ITGB3BP  
Affinity Capture-MS Homo sapiens
131 NOP2 4839
Affinity Capture-MS Homo sapiens
132 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
133 SNRNP200 23020
Affinity Capture-MS Homo sapiens
134 RPS6KB1 6198
Co-fractionation Homo sapiens
135 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
136 RPS27A 6233
Affinity Capture-MS Homo sapiens
137 CHMP4B 128866
Affinity Capture-MS Homo sapiens
138 TIMELESS  
Affinity Capture-Western Homo sapiens
139 MYH9 4627
Affinity Capture-MS Homo sapiens
140 DDX5 1655
Affinity Capture-MS Homo sapiens
141 NTRK1 4914
Affinity Capture-MS Homo sapiens
142 RDH13  
Affinity Capture-MS Homo sapiens
143 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
144 S100A8 6279
Affinity Capture-MS Homo sapiens
145 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
146 PLK1 5347
Affinity Capture-Western Homo sapiens
147 GINS1  
Affinity Capture-MS Homo sapiens
148 NCL 4691
Affinity Capture-MS Homo sapiens
149 DICER1  
Affinity Capture-MS Homo sapiens
150 HUWE1 10075
Affinity Capture-MS Homo sapiens
151 ARRDC3 57561
Affinity Capture-MS Homo sapiens
152 SPTBN1 6711
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
153 CRY2  
Affinity Capture-MS Homo sapiens
154 USP48  
Co-fractionation Homo sapiens
155 KPRP 448834
Affinity Capture-MS Homo sapiens
156 DHX9 1660
Affinity Capture-MS Homo sapiens
157 DDX17 10521
Affinity Capture-MS Homo sapiens
158 HIST1H2BK 85236
Affinity Capture-MS Homo sapiens
159 PELP1 27043
Affinity Capture-MS Homo sapiens
160 PRKAR1B  
Affinity Capture-MS Homo sapiens
161 CALML5 51806
Affinity Capture-MS Homo sapiens
162 HNRNPA3 220988
Affinity Capture-MS Homo sapiens
163 HDAC5 10014
Affinity Capture-MS Homo sapiens
164 DDX27 55661
Affinity Capture-MS Homo sapiens
165 CEBPA  
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
166 CYLD  
Affinity Capture-MS Homo sapiens
167 SF3A3 10946
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
168 U2SURP 23350
Affinity Capture-MS Homo sapiens
169 STK32C  
Affinity Capture-MS Homo sapiens
170 SLC25A5 292
Affinity Capture-MS Homo sapiens
171 CELSR2  
Affinity Capture-MS Homo sapiens
172 KRTAP10-7  
Two-hybrid Homo sapiens
173 LARP1 23367
Co-fractionation Homo sapiens
174 BAG3 9531
Affinity Capture-MS Homo sapiens
175 ATG16L1 55054
Affinity Capture-MS Homo sapiens
176 TONSL  
Affinity Capture-MS Homo sapiens
177 ACTN1 87
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
178 HIST1H2AD 3013
Affinity Capture-MS Homo sapiens
179 TMPO 7112
Affinity Capture-MS Homo sapiens
180 HERC1 8925
Affinity Capture-MS Homo sapiens
181 PSMA3 5684
Co-fractionation Homo sapiens
182 PYGB 5834
Affinity Capture-MS Homo sapiens
183 TUBB2A 7280
Affinity Capture-MS Homo sapiens
184 FANCD2  
Affinity Capture-MS Homo sapiens
185 ACTBL2 345651
Affinity Capture-MS Homo sapiens
186 NAE1 8883
Co-fractionation Homo sapiens
187 DHX15 1665
Affinity Capture-MS Homo sapiens
188 RRAGA 10670
Co-fractionation Homo sapiens
189 CIAO1 9391
Affinity Capture-MS Homo sapiens
190 LGALS1 3956
Affinity Capture-MS Homo sapiens
191 SDHA 6389
Affinity Capture-MS Homo sapiens
192 LANCL1 10314
Affinity Capture-MS Homo sapiens
193 CLPP 8192
Proximity Label-MS Homo sapiens
194 SIRT7  
Affinity Capture-MS Homo sapiens
195 HIST2H2BF 440689
Affinity Capture-MS Homo sapiens
196 NAT10 55226
Affinity Capture-MS Homo sapiens
197 CTNNB1 1499
Affinity Capture-MS Homo sapiens
198 TUBB4A 10382
Affinity Capture-MS Homo sapiens
199 HIST1H2BC 8347
Affinity Capture-MS Homo sapiens
200 CUL3 8452
Affinity Capture-MS Homo sapiens
201 NR3C1 2908
Proximity Label-MS Homo sapiens
202 DCAF13 25879
Affinity Capture-MS Homo sapiens
203 TUBB4B 10383
Affinity Capture-MS Homo sapiens
204 UBBP4 23666
Affinity Capture-MS Homo sapiens
205 HIST1H2BH 8345
Affinity Capture-MS Homo sapiens
206 HSD17B10 3028
Affinity Capture-MS Homo sapiens
207 HOOK3 84376
Proximity Label-MS Homo sapiens
208 KIF2A 3796
Co-fractionation Homo sapiens
209 MCM4 4173
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
210 H3F3B 3021
Affinity Capture-MS Homo sapiens
211 GPRASP2  
Affinity Capture-MS Homo sapiens
212 FN1 2335
Affinity Capture-MS Homo sapiens
213 PUS7 54517
Co-fractionation Homo sapiens
214 MYO1C 4641
Affinity Capture-MS Homo sapiens
215 ERP44 23071
Affinity Capture-MS Homo sapiens
216 SF3A1 10291
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
217 PRMT5 10419
Co-fractionation Homo sapiens
218 FKBP5 2289
Co-fractionation Homo sapiens
219 HNRNPR 10236
Affinity Capture-MS Homo sapiens
220 PCBP1 5093
Affinity Capture-MS Homo sapiens
221 ARHGAP29 9411
Affinity Capture-MS Homo sapiens
222 STAT1 6772
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
223 FBXO6 26270
Affinity Capture-MS Homo sapiens
224 RPA3 6119
Proximity Label-MS Homo sapiens
225 HIST1H2BA 255626
Affinity Capture-MS Homo sapiens
226 MCMBP 79892
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
227 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
228 TOP1 7150
Affinity Capture-MS Homo sapiens
229 HSPA1A 3303
Affinity Capture-MS Homo sapiens
230 CFL2 1073
Affinity Capture-MS Homo sapiens
231 CDC45  
Affinity Capture-Western Homo sapiens
232 ATRIP  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
233 DDB1 1642
Co-fractionation Homo sapiens
234 ENO1 2023
Affinity Capture-MS Homo sapiens
235 PLEKHG1  
Affinity Capture-MS Homo sapiens
236 RNF2  
Affinity Capture-MS Homo sapiens
237 SF3B3 23450
Affinity Capture-MS Homo sapiens
238 RPS18 6222
Affinity Capture-MS Homo sapiens
239 HSPA4L 22824
Co-fractionation Homo sapiens
240 HIST2H3A 333932
Affinity Capture-MS Homo sapiens
241 FAM188A 80013
Affinity Capture-MS Homo sapiens
242 CDC7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
243 HSPA9 3313
Affinity Capture-MS Homo sapiens
244 KRT19 3880
Affinity Capture-MS Homo sapiens
245 BCAS2 10286
Co-fractionation Homo sapiens
246 HIST1H2AJ 8331
Affinity Capture-MS Homo sapiens
247 CAMK2G 818
Affinity Capture-MS Homo sapiens
248 MLEC 9761
Affinity Capture-MS Homo sapiens
249 CCDC8  
Affinity Capture-MS Homo sapiens
250 H2AFX 3014
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
251 H3F3C 440093
Affinity Capture-MS Homo sapiens
252 APP 351
Reconstituted Complex Homo sapiens
253 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
254 NES 10763
Affinity Capture-MS Homo sapiens
255 KRT18 3875
Affinity Capture-MS Homo sapiens
256 YBX1 4904
Affinity Capture-MS Homo sapiens
257 KIAA0232 9778
Affinity Capture-MS Homo sapiens
258 SNCA 6622
Affinity Capture-MS Homo sapiens
259 FHL1 2273
Affinity Capture-MS Homo sapiens
260 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
261 PHB2 11331
Affinity Capture-MS Homo sapiens
262 HIST1H2BO 8348
Affinity Capture-MS Homo sapiens
263 SIRT6  
Affinity Capture-MS Homo sapiens
264 PARP1 142
Affinity Capture-MS Homo sapiens
265 CLTC 1213
Co-fractionation Homo sapiens
266 ILF3 3609
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
267 JUP 3728
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
268 H3F3A 3020
Affinity Capture-MS Homo sapiens
269 TP53 7157
Affinity Capture-MS Homo sapiens
270 HIST2H2BC 337873
Affinity Capture-MS Homo sapiens
271 CAMK2B 816
Affinity Capture-MS Homo sapiens
272 PYGL 5836
Affinity Capture-MS Homo sapiens
273 ASF1B  
Affinity Capture-MS Homo sapiens
274 CDKN2A 1029
Reconstituted Complex Homo sapiens
275 VIM 7431
Affinity Capture-MS Homo sapiens
276 HIST3H2A 92815
Affinity Capture-MS Homo sapiens
277 RICTOR 253260
Affinity Capture-MS Homo sapiens
278 IFT52 51098
Affinity Capture-MS Homo sapiens
279 HNRNPA2B1 3181
Affinity Capture-MS Homo sapiens
280 PDHA1 5160
Co-fractionation Homo sapiens
281 VWA9  
Affinity Capture-MS Homo sapiens
282 TUBB3 10381
Affinity Capture-MS Homo sapiens
283 HIST1H2BN 8341
Affinity Capture-MS Homo sapiens
284 THRAP3 9967
Affinity Capture-MS Homo sapiens
285 CDC6  
Affinity Capture-Western Homo sapiens
286 FANCI 55215
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
287 CLUH 23277
Co-fractionation Homo sapiens
288 HIST1H2BD 3017
Affinity Capture-MS Homo sapiens
289 HSP90AA1 3320
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
290 RBMX 27316
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
291 S100A9 6280
Affinity Capture-MS Homo sapiens
292 FANCA  
Affinity Capture-Luminescence Homo sapiens
293 MKI67  
Affinity Capture-MS Homo sapiens
294 MYBBP1A 10514
Co-fractionation Homo sapiens
295 RAB11FIP1 80223
Co-fractionation Homo sapiens
296 RAD50 10111
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
297 ESR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
298 UFL1 23376
Affinity Capture-MS Homo sapiens
299 ANXA2P2 304
Affinity Capture-MS Homo sapiens
300 UBB 7314
Affinity Capture-MS Homo sapiens
301 H2AFJ 55766
Affinity Capture-MS Homo sapiens
302 PYGM 5837
Affinity Capture-MS Homo sapiens
303 HIST2H3PS2 440686
Affinity Capture-MS Homo sapiens
304 EEF1A1P5 158078
Affinity Capture-MS Homo sapiens
305 API5 8539
Co-fractionation Homo sapiens
306 LAGE3  
Co-fractionation Homo sapiens
307 TGM3 7053
Affinity Capture-MS Homo sapiens
308 ARHGAP36  
Affinity Capture-MS Homo sapiens
309 EIF4B 1975
Co-fractionation Homo sapiens
310 HNRNPC 3183
Affinity Capture-MS Homo sapiens
311 AIRE  
Affinity Capture-MS Homo sapiens
312 FLNA 2316
Affinity Capture-MS Homo sapiens
313 PINK1  
Affinity Capture-MS Homo sapiens
314 PRDX1 5052
Affinity Capture-MS Homo sapiens
315 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
316 HNRNPA1L2 144983
Affinity Capture-MS Homo sapiens
317 L3MBTL1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
318 FLNC 2318
Affinity Capture-MS Homo sapiens
319 ORC1  
Reconstituted Complex Homo sapiens
320 CEBPB  
Co-fractionation Homo sapiens
321 PIP 5304
Affinity Capture-MS Homo sapiens
322 KRAS 3845
Negative Genetic Homo sapiens
323 HNRNPU 3192
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
324 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
325 NEK9 91754
Co-fractionation Homo sapiens
326 ANXA2 302
Affinity Capture-MS Homo sapiens
327 CAMK2D 817
Affinity Capture-MS Homo sapiens
328 SSRP1 6749
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
329 PRMT1 3276
Affinity Capture-MS Homo sapiens
330 Clspn  
Affinity Capture-MS Mus musculus
331 NOTCH1 4851
Affinity Capture-MS Homo sapiens
332 WDR62  
Affinity Capture-MS Homo sapiens
333 TOP1MT  
Affinity Capture-MS Homo sapiens
334 HIST1H2AH 85235
Affinity Capture-MS Homo sapiens
335 EP300 2033
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
336 CDC5L 988
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
337 UBA52 7311
Affinity Capture-MS Homo sapiens
338 ESCO2  
Reconstituted Complex Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here