Gene description for HIST1H2BK
Gene name histone cluster 1, H2bk
Gene symbol HIST1H2BK
Other names/aliases H2B/S
H2BFAiii
H2BFT
H2BK
Species Homo sapiens
 Database cross references - HIST1H2BK
ExoCarta ExoCarta_85236
Vesiclepedia VP_85236
Entrez Gene 85236
HGNC 13954
MIM 615045
UniProt O60814  
 HIST1H2BK identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
 Gene ontology annotations for HIST1H2BK
Molecular Function
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    structural constituent of chromatin GO:0030527 IEA
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    innate immune response in mucosa GO:0002227 IDA
    antibacterial humoral response GO:0019731 IDA
    killing of cells of another organism GO:0031640 IDA
    defense response to Gram-negative bacterium GO:0050829 IDA
    defense response to Gram-positive bacterium GO:0050830 IDA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
Subcellular Localization
    nucleosome GO:0000786 IEA
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
 Experiment description of studies that identified HIST1H2BK in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 138
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
3
Experiment ID 139
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
4
Experiment ID 140
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
5
Experiment ID 141
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
6
Experiment ID 142
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
7
Experiment ID 143
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
8
Experiment ID 144
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
9
Experiment ID 145
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD10
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
10
Experiment ID 146
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
11
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
12
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for HIST1H2BK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IWS1  
Cross-Linking-MS (XL-MS) Homo sapiens
2 HIST2H2BE 8349
Cross-Linking-MS (XL-MS) Homo sapiens
3 H2AFJ 55766
Cross-Linking-MS (XL-MS) Homo sapiens
4 MESDC2 23184
Cross-Linking-MS (XL-MS) Homo sapiens
5 SMC3 9126
Cross-Linking-MS (XL-MS) Homo sapiens
6 SPRTN  
Affinity Capture-MS Homo sapiens
7 NOLC1 9221
Cross-Linking-MS (XL-MS) Homo sapiens
8 ZBTB11  
Cross-Linking-MS (XL-MS) Homo sapiens
9 EEF1G 1937
Cross-Linking-MS (XL-MS) Homo sapiens
10 CENPE 1062
Cross-Linking-MS (XL-MS) Homo sapiens
11 HIST1H4G 8369
Cross-Linking-MS (XL-MS) Homo sapiens
12 TEX35  
Cross-Linking-MS (XL-MS) Homo sapiens
13 PDAP1 11333
Cross-Linking-MS (XL-MS) Homo sapiens
14 AKAP4  
Cross-Linking-MS (XL-MS) Homo sapiens
15 HIST1H1D 3007
Cross-Linking-MS (XL-MS) Homo sapiens
16 BTF3 689
Affinity Capture-MS Homo sapiens
17 ABCF1 23
Cross-Linking-MS (XL-MS) Homo sapiens
18 ACTC1 70
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
19 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
20 MAP4 4134
Cross-Linking-MS (XL-MS) Homo sapiens
21 ZNF638 27332
Cross-Linking-MS (XL-MS) Homo sapiens
22 HIST1H2BB 3018
Cross-Linking-MS (XL-MS) Homo sapiens
23 NUMA1 4926
Cross-Linking-MS (XL-MS) Homo sapiens
24 UBC 7316
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
25 SSB 6741
Cross-Linking-MS (XL-MS) Homo sapiens
26 BASP1 10409
Cross-Linking-MS (XL-MS) Homo sapiens
27 DNAJB3 414061
Cross-Linking-MS (XL-MS) Homo sapiens
28 LMNA 4000
Cross-Linking-MS (XL-MS) Homo sapiens
29 SNRPD2 6633
Cross-Linking-MS (XL-MS) Homo sapiens
30 GSK3A 2931
Affinity Capture-MS Homo sapiens
31 USP36  
Affinity Capture-MS Homo sapiens
32 MYO1H  
Cross-Linking-MS (XL-MS) Homo sapiens
33 WTAP 9589
Affinity Capture-MS Homo sapiens
34 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
35 ZNF474  
Cross-Linking-MS (XL-MS) Homo sapiens
36 SAE1 10055
Cross-Linking-MS (XL-MS) Homo sapiens
37 SKIV2L2 23517
Cross-Linking-MS (XL-MS) Homo sapiens
38 CEP104  
Cross-Linking-MS (XL-MS) Homo sapiens
39 IFT74 80173
Cross-Linking-MS (XL-MS) Homo sapiens
40 MCM2 4171
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
41 H1FX 8971
Cross-Linking-MS (XL-MS) Homo sapiens
42 C18orf25 147339
Cross-Linking-MS (XL-MS) Homo sapiens
43 PHLDA2 7262
Cross-Linking-MS (XL-MS) Homo sapiens
44 EIF4A3 9775
Cross-Linking-MS (XL-MS) Homo sapiens
45 RRP12 23223
Cross-Linking-MS (XL-MS) Homo sapiens
46 H2AFV 94239
Cross-Linking-MS (XL-MS) Homo sapiens
47 HIST2H3A 333932
Cross-Linking-MS (XL-MS) Homo sapiens
48 C8orf59  
Cross-Linking-MS (XL-MS) Homo sapiens
49 FAM47B  
Cross-Linking-MS (XL-MS) Homo sapiens
50 H2AFY2 55506
Cross-Linking-MS (XL-MS) Homo sapiens
51 TRO  
Cross-Linking-MS (XL-MS) Homo sapiens
52 EIF5B 9669
Cross-Linking-MS (XL-MS) Homo sapiens
53 MCM6 4175
Cross-Linking-MS (XL-MS) Homo sapiens
54 HMGA1 3159
Cross-Linking-MS (XL-MS) Homo sapiens
55 HCLS1 3059
Cross-Linking-MS (XL-MS) Homo sapiens
56 ANKRD36 375248
Cross-Linking-MS (XL-MS) Homo sapiens
57 ADAMTS12 81792
Cross-Linking-MS (XL-MS) Homo sapiens
58 SMCHD1 23347
Cross-Linking-MS (XL-MS) Homo sapiens
59 ENPP1 5167
Cross-Linking-MS (XL-MS) Homo sapiens
60 BRD4 23476
Cross-Linking-MS (XL-MS) Homo sapiens
61 VCAM1 7412
Affinity Capture-MS Homo sapiens
62 YY1 7528
Cross-Linking-MS (XL-MS) Homo sapiens
63 MTDH 92140
Cross-Linking-MS (XL-MS) Homo sapiens
64 PDS5B 23047
Cross-Linking-MS (XL-MS) Homo sapiens
65 ARIH2 10425
Affinity Capture-MS Homo sapiens
66 FAF2 23197
Cross-Linking-MS (XL-MS) Homo sapiens
67 ALG5 29880
Cross-Linking-MS (XL-MS) Homo sapiens
68 EEF1A1 1915
Cross-Linking-MS (XL-MS) Homo sapiens
69 GSK3B 2932
Affinity Capture-MS Homo sapiens
70 KIF14 9928
Affinity Capture-MS Homo sapiens
71 CLASP2 23122
Cross-Linking-MS (XL-MS) Homo sapiens
72 HIST3H2BB 128312
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
73 PAK3  
Cross-Linking-MS (XL-MS) Homo sapiens
74 H2AFZ 3015
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
75 DLAT 1737
Cross-Linking-MS (XL-MS) Homo sapiens
76 SCAF1  
Cross-Linking-MS (XL-MS) Homo sapiens
77 MYH10 4628
Cross-Linking-MS (XL-MS) Homo sapiens
78 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
79 NEB 4703
Cross-Linking-MS (XL-MS) Homo sapiens
80 DPPA2  
Cross-Linking-MS (XL-MS) Homo sapiens
81 TOP2B 7155
Cross-Linking-MS (XL-MS) Homo sapiens
82 CDK5 1020
Cross-Linking-MS (XL-MS) Homo sapiens
83 MAP1B 4131
Cross-Linking-MS (XL-MS) Homo sapiens
84 CCDC88C 440193
Cross-Linking-MS (XL-MS) Homo sapiens
85 HMGN2 3151
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
86 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
87 XRN1 54464
Cross-Linking-MS (XL-MS) Homo sapiens
88 PNN 5411
Cross-Linking-MS (XL-MS) Homo sapiens
89 PSMD14 10213
Affinity Capture-MS Homo sapiens
90 NOP2 4839
Cross-Linking-MS (XL-MS) Homo sapiens
91 CBX3 11335
Cross-Linking-MS (XL-MS) Homo sapiens
92 ABCF2 10061
Cross-Linking-MS (XL-MS) Homo sapiens
93 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
94 SLC25A6 293
Cross-Linking-MS (XL-MS) Homo sapiens
95 CHMP4B 128866
Cross-Linking-MS (XL-MS) Homo sapiens
96 TNRC18  
Cross-Linking-MS (XL-MS) Homo sapiens
97 MYH9 4627
Cross-Linking-MS (XL-MS) Homo sapiens
98 RAN 5901
Cross-Linking-MS (XL-MS) Homo sapiens
99 TTN 7273
Cross-Linking-MS (XL-MS) Homo sapiens
100 CKAP5 9793
Cross-Linking-MS (XL-MS) Homo sapiens
101 SHROOM3 57619
Cross-Linking-MS (XL-MS) Homo sapiens
102 LYRM7  
Cross-Linking-MS (XL-MS) Homo sapiens
103 PCLO 27445
Cross-Linking-MS (XL-MS) Homo sapiens
104 RLIM 51132
Affinity Capture-MS Homo sapiens
105 PTGES2 80142
Cross-Linking-MS (XL-MS) Homo sapiens
106 SPAG17  
Cross-Linking-MS (XL-MS) Homo sapiens
107 PPME1 51400
Cross-Linking-MS (XL-MS) Homo sapiens
108 HIST1H1C 3006
Cross-Linking-MS (XL-MS) Homo sapiens
109 RPL27A 6157
Cross-Linking-MS (XL-MS) Homo sapiens
110 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
111 CHD5 26038
Cross-Linking-MS (XL-MS) Homo sapiens
112 MYH11 4629
Cross-Linking-MS (XL-MS) Homo sapiens
113 ENY2 56943
Cross-Linking-MS (XL-MS) Homo sapiens
114 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
115 ATRX 546
Cross-Linking-MS (XL-MS) Homo sapiens
116 DDX39B 7919
Cross-Linking-MS (XL-MS) Homo sapiens
117 AHCTF1 25909
Cross-Linking-MS (XL-MS) Homo sapiens
118 CYLC1 1538
Cross-Linking-MS (XL-MS) Homo sapiens
119 H2AFY 9555
Cross-Linking-MS (XL-MS) Homo sapiens
120 DDX27 55661
Cross-Linking-MS (XL-MS) Homo sapiens
121 PRMT8  
Cross-Linking-MS (XL-MS) Homo sapiens
122 CYLD  
Affinity Capture-MS Homo sapiens
123 HIST1H2AB 8335
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
124 HIST1H2BJ 8970
Cross-Linking-MS (XL-MS) Homo sapiens
125 IPO9 55705
Cross-Linking-MS (XL-MS) Homo sapiens
126 HIST1H2AI 8329
Cross-Linking-MS (XL-MS) Homo sapiens
127 LARP1 23367
Cross-Linking-MS (XL-MS) Homo sapiens
128 HMGN3  
Cross-Linking-MS (XL-MS) Homo sapiens
129 HMGN1  
Cross-Linking-MS (XL-MS) Homo sapiens
130 DST 667
Cross-Linking-MS (XL-MS) Homo sapiens
131 HIST1H2AA 221613
Cross-Linking-MS (XL-MS) Homo sapiens
132 HNRNPD 3184
Affinity Capture-MS Homo sapiens
133 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
134 HIST1H2AD 3013
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
135 CPSF1 29894
Cross-Linking-MS (XL-MS) Homo sapiens
136 GPC4 2239
Cross-Linking-MS (XL-MS) Homo sapiens
137 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
138 FANCD2  
Affinity Capture-MS Homo sapiens
139 KMT2A  
Cross-Linking-MS (XL-MS) Homo sapiens
140 METTL14  
Affinity Capture-MS Homo sapiens
141 ATL3 25923
Cross-Linking-MS (XL-MS) Homo sapiens
142 NOL8  
Cross-Linking-MS (XL-MS) Homo sapiens
143 HIST2H3C 126961
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
144 RALB 5899
Cross-Linking-MS (XL-MS) Homo sapiens
145 HIST2H2BF 440689
Cross-Linking-MS (XL-MS) Homo sapiens
146 AHNAK 79026
Cross-Linking-MS (XL-MS) Homo sapiens
147 USP16  
Cross-Linking-MS (XL-MS) Homo sapiens
148 ERC2 26059
Cross-Linking-MS (XL-MS) Homo sapiens
149 BCAP31 10134
Cross-Linking-MS (XL-MS) Homo sapiens
150 CDK5R2 8941
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
151 YLPM1 56252
Cross-Linking-MS (XL-MS) Homo sapiens
152 PDIA3 2923
Cross-Linking-MS (XL-MS) Homo sapiens
153 AEBP1 165
Cross-Linking-MS (XL-MS) Homo sapiens
154 LRRC47 57470
Cross-Linking-MS (XL-MS) Homo sapiens
155 H1F0 3005
Cross-Linking-MS (XL-MS) Homo sapiens
156 MCM4 4173
Cross-Linking-MS (XL-MS) Homo sapiens
157 METTL3  
Affinity Capture-MS Homo sapiens
158 POLR2A 5430
Cross-Linking-MS (XL-MS) Homo sapiens
159 SLTM 79811
Cross-Linking-MS (XL-MS) Homo sapiens
160 HIST3H3 8290
Cross-Linking-MS (XL-MS) Homo sapiens
161 FN1 2335
Affinity Capture-MS Homo sapiens
162 HIST1H2BO 8348
Cross-Linking-MS (XL-MS) Homo sapiens
163 TOMM70A 9868
Cross-Linking-MS (XL-MS) Homo sapiens
164 PDCD4 27250
Cross-Linking-MS (XL-MS) Homo sapiens
165 PRKACA 5566
Cross-Linking-MS (XL-MS) Homo sapiens
166 MAPK6  
Cross-Linking-MS (XL-MS) Homo sapiens
167 ACSL3 2181
Cross-Linking-MS (XL-MS) Homo sapiens
168 HIST1H2AH 85235
Cross-Linking-MS (XL-MS) Homo sapiens
169 BAG1 573
Affinity Capture-MS Homo sapiens
170 HIST1H2BA 255626
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
171 UBA52 7311
Cross-Linking-MS (XL-MS) Homo sapiens
172 PRDM13 59336
Affinity Capture-MS Homo sapiens
173 EEF1A2 1917
Cross-Linking-MS (XL-MS) Homo sapiens
174 HP1BP3 50809
Cross-Linking-MS (XL-MS) Homo sapiens
175 EPRS 2058
Cross-Linking-MS (XL-MS) Homo sapiens
176 UPF3B 65109
Cross-Linking-MS (XL-MS) Homo sapiens
177 PARP4 143
Cross-Linking-MS (XL-MS) Homo sapiens
178 SGTA 6449
Cross-Linking-MS (XL-MS) Homo sapiens
179 SEPT7 989
Cross-Linking-MS (XL-MS) Homo sapiens
180 VBP1 7411
Cross-Linking-MS (XL-MS) Homo sapiens
181 H2AFB2  
Affinity Capture-MS Homo sapiens
182 SFMBT2  
Cross-Linking-MS (XL-MS) Homo sapiens
183 CEP350 9857
Cross-Linking-MS (XL-MS) Homo sapiens
184 HIST1H1T 3010
Cross-Linking-MS (XL-MS) Homo sapiens
185 UPF2 26019
Cross-Linking-MS (XL-MS) Homo sapiens
186 MAP7D2 256714
Cross-Linking-MS (XL-MS) Homo sapiens
187 MDM2  
Cross-Linking-MS (XL-MS) Homo sapiens
188 HDGF 3068
Affinity Capture-MS Homo sapiens
189 HUWE1 10075
Cross-Linking-MS (XL-MS) Homo sapiens
190 H2AFX 3014
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
191 RRM1 6240
Cross-Linking-MS (XL-MS) Homo sapiens
192 AHSA1 10598
Cross-Linking-MS (XL-MS) Homo sapiens
193 SS18  
Cross-Linking-MS (XL-MS) Homo sapiens
194 RPS27A 6233
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
195 C11orf58  
Cross-Linking-MS (XL-MS) Homo sapiens
196 NAA15 80155
Cross-Linking-MS (XL-MS) Homo sapiens
197 PRRC2A 7916
Cross-Linking-MS (XL-MS) Homo sapiens
198 SIRT6  
Affinity Capture-MS Homo sapiens
199 DIDO1  
Cross-Linking-MS (XL-MS) Homo sapiens
200 HMGN4  
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
201 HIST1H2AC 8334
Cross-Linking-MS (XL-MS) Homo sapiens
202 SRRM1 10250
Cross-Linking-MS (XL-MS) Homo sapiens
203 TNN 63923
Cross-Linking-MS (XL-MS) Homo sapiens
204 ATP1A3 478
Cross-Linking-MS (XL-MS) Homo sapiens
205 EIF1AX 1964
Cross-Linking-MS (XL-MS) Homo sapiens
206 SUCLG2 8801
Cross-Linking-MS (XL-MS) Homo sapiens
207 MCM5 4174
Affinity Capture-MS Homo sapiens
208 JPH2 57158
Cross-Linking-MS (XL-MS) Homo sapiens
209 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
210 STMN1 3925
Cross-Linking-MS (XL-MS) Homo sapiens
211 FAM3C 10447
Cross-Linking-MS (XL-MS) Homo sapiens
212 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
213 HMGN5 79366
Cross-Linking-MS (XL-MS) Homo sapiens
214 KNOP1 400506
Cross-Linking-MS (XL-MS) Homo sapiens
215 KIAA1109 84162
Cross-Linking-MS (XL-MS) Homo sapiens
216 HIST1H2BN 8341
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
217 SECISBP2L  
Cross-Linking-MS (XL-MS) Homo sapiens
218 FANCI 55215
Cross-Linking-MS (XL-MS) Homo sapiens
219 GPD1L 23171
Cross-Linking-MS (XL-MS) Homo sapiens
220 CHD1L 9557
Affinity Capture-MS Homo sapiens
221 PHF3  
Cross-Linking-MS (XL-MS) Homo sapiens
222 H2AFB3  
Affinity Capture-MS Homo sapiens
223 CNOT3 4849
Cross-Linking-MS (XL-MS) Homo sapiens
224 PRRC2B  
Cross-Linking-MS (XL-MS) Homo sapiens
225 HDAC5 10014
Affinity Capture-MS Homo sapiens
226 PRMT3 10196
Cross-Linking-MS (XL-MS) Homo sapiens
227 TOP2A 7153
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
228 PPM1G 5496
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
229 DHX40  
Cross-Linking-MS (XL-MS) Homo sapiens
230 UBB 7314
Cross-Linking-MS (XL-MS) Homo sapiens
231 STRN4 29888
Cross-Linking-MS (XL-MS) Homo sapiens
232 EEF1A1P5 158078
Cross-Linking-MS (XL-MS) Homo sapiens
233 NCL 4691
Cross-Linking-MS (XL-MS) Homo sapiens
234 EZH2  
Cross-Linking-MS (XL-MS) Homo sapiens
235 VPS26B 112936
Cross-Linking-MS (XL-MS) Homo sapiens
236 EIF4B 1975
Cross-Linking-MS (XL-MS) Homo sapiens
237 DUOX2 50506
Cross-Linking-MS (XL-MS) Homo sapiens
238 STAG2 10735
Cross-Linking-MS (XL-MS) Homo sapiens
239 OSBPL9 114883
Cross-Linking-MS (XL-MS) Homo sapiens
240 PINK1  
Affinity Capture-MS Homo sapiens
241 FGFR1OP  
Cross-Linking-MS (XL-MS) Homo sapiens
242 HNRNPA1L2 144983
Cross-Linking-MS (XL-MS) Homo sapiens
243 ANKRD11 29123
Cross-Linking-MS (XL-MS) Homo sapiens
244 RPRD1B 58490
Cross-Linking-MS (XL-MS) Homo sapiens
245 SERBP1 26135
Affinity Capture-MS Homo sapiens
246 HIRA  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
247 C9orf72  
Affinity Capture-MS Homo sapiens
248 RC3H1 149041
Affinity Capture-MS Homo sapiens
249 PWWP2A  
Cross-Linking-MS (XL-MS) Homo sapiens
250 AP3D1 8943
Cross-Linking-MS (XL-MS) Homo sapiens
251 WDHD1  
Cross-Linking-MS (XL-MS) Homo sapiens
252 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
253 TIMM44 10469
Cross-Linking-MS (XL-MS) Homo sapiens
254 EIF5 1983
Cross-Linking-MS (XL-MS) Homo sapiens
255 HNRNPA2B1 3181
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which HIST1H2BK is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 TAS Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Amyloid fiber formation TAS Reactome
Assembly of the ORC complex at the origin of replication TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
B-WICH complex positively regulates rRNA expression TAS Reactome
Base Excision Repair TAS Reactome
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation TAS Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromatin modifications during the maternal to zygotic transition (MZT) IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization TAS Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance TAS Reactome
Cleavage of the damaged purine TAS Reactome
Cleavage of the damaged purine IEA Reactome
Cleavage of the damaged pyrimidine IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Defective pyroptosis TAS Reactome
Deposition of new CENPA-containing nucleosomes at the centromere TAS Reactome
Depurination TAS Reactome
Depurination IEA Reactome
Depyrimidination IEA Reactome
Deubiquitination TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA methylation IEA Reactome
DNA Repair TAS Reactome
DNA Repair IEA Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
E3 ubiquitin ligases ubiquitinate target proteins TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
Formation of the beta-catenin:TCF transactivating complex TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway IEA Reactome
Generic Transcription Pathway TAS Reactome
HATs acetylate histones TAS Reactome
HATs acetylate histones IEA Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HCMV Late Events TAS Reactome
HDACs deacetylate histones TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Homology Directed Repair TAS Reactome
Infectious disease TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
M Phase TAS Reactome
Maternal to zygotic transition (MZT) IEA Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Meiotic synapsis IEA Reactome
Metabolism of proteins TAS Reactome
Mitotic Prophase TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Negative epigenetic regulation of rRNA expression TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
Nonhomologous End-Joining (NHEJ) TAS Reactome
NoRC negatively regulates rRNA expression TAS Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Nucleosome assembly TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Packaging Of Telomere Ends TAS Reactome
Positive epigenetic regulation of rRNA expression TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
Post-translational protein modification TAS Reactome
PRC2 methylates histones and DNA TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
Processing of DNA double-strand break ends TAS Reactome
Protein ubiquitination TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected pyrimidine IEA Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Regulation of endogenous retroelements TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins TAS Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TAS Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
Replacement of protamines by nucleosomes in the male pronucleus IEA Reactome
Reproduction IEA Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases activate PKNs TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Promoter Opening TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT TAS Reactome
SIRT1 negatively regulates rRNA expression TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
TCF dependent signaling in response to WNT TAS Reactome
Telomere Maintenance TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional regulation of granulopoiesis IEA Reactome
Ub-specific processing proteases TAS Reactome
Viral Infection Pathways TAS Reactome





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