Gene description for PPM1G
Gene name protein phosphatase, Mg2+/Mn2+ dependent, 1G
Gene symbol PPM1G
Other names/aliases PP2CG
PP2CGAMMA
PPP2CG
Species Homo sapiens
 Database cross references - PPM1G
ExoCarta ExoCarta_5496
Vesiclepedia VP_5496
Entrez Gene 5496
HGNC 9278
MIM 605119
UniProt O15355  
 PPM1G identified in sEVs derived from the following tissue/cell type
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Hepatocytes 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
T lymphocytes 34108659    
 Gene ontology annotations for PPM1G
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IDA
    protein binding GO:0005515 IPI
    myosin phosphatase activity GO:0017018 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    metal ion binding GO:0046872 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    protein dephosphorylation GO:0006470 TAS
    signal transduction GO:0007165 IBA
    peptidyl-threonine dephosphorylation GO:0035970 IDA
    regulation of cell cycle GO:0051726 IEA
Subcellular Localization
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IEA
    membrane GO:0016020 IEA
 Experiment description of studies that identified PPM1G in sEVs
1
Experiment ID 412
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
2
Experiment ID 414
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
3
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 407
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 405
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
11
Experiment ID 237
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
12
Experiment ID 417
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
13
Experiment ID 411
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
14
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
15
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
16
Experiment ID 413
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
17
Experiment ID 211
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 212
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 406
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 415
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
23
Experiment ID 408
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 409
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 416
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 410
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for PPM1G
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 EIF3A 8661
Co-fractionation Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 COPG2 26958
Affinity Capture-MS Homo sapiens
5 H2AFJ 55766
Affinity Capture-MS Homo sapiens
6 HIST1H2BE 8344
Affinity Capture-MS Homo sapiens
7 NCBP1 4686
Co-fractionation Homo sapiens
8 FOXK2  
Affinity Capture-MS Homo sapiens
9 DNAJC8 22826
Affinity Capture-MS Homo sapiens
10 EIF3C 8663
Co-fractionation Homo sapiens
11 HIST1H4A 8359
Co-fractionation Homo sapiens
12 PAWR 5074
Co-fractionation Homo sapiens
13 TPD52L2 7165
Co-fractionation Homo sapiens
14 KCTD10 83892
Affinity Capture-MS Homo sapiens
15 PUF60 22827
Co-fractionation Homo sapiens
16 DNTTIP1 116092
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 STAM 8027
Co-fractionation Homo sapiens
18 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
19 SNX2 6643
Cross-Linking-MS (XL-MS) Homo sapiens
20 NOP56 10528
Proximity Label-MS Homo sapiens
21 COPB2 9276
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 HIST1H2BB 3018
Affinity Capture-MS Homo sapiens
23 TLE3  
Co-fractionation Homo sapiens
24 FAM21A 387680
Co-fractionation Homo sapiens
25 HIST3H2BB 128312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 DNAJC25 548645
Affinity Capture-MS Homo sapiens
27 KPNA2 3838
Affinity Capture-MS Homo sapiens
28 TERF2IP 54386
Two-hybrid Homo sapiens
29 GJA1 2697
Affinity Capture-MS Homo sapiens
30 RPS6KB2  
Affinity Capture-MS Homo sapiens
31 DNAJC15  
Affinity Capture-MS Homo sapiens
32 SBDS 51119
Affinity Capture-MS Homo sapiens
33 VPS29 51699
Co-fractionation Homo sapiens
34 CENPA  
Proximity Label-MS Homo sapiens
35 DNAJB6 10049
Proximity Label-MS Homo sapiens
36 TRMT10C 54931
Co-fractionation Homo sapiens
37 USP36  
Affinity Capture-MS Homo sapiens
38 KIAA1429 25962
Affinity Capture-MS Homo sapiens
39 TROVE2 6738
Co-fractionation Homo sapiens
40 SNX3 8724
Co-fractionation Homo sapiens
41 B3GNT2 10678
Affinity Capture-MS Homo sapiens
42 TFAM 7019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 DYRK1A 1859
Affinity Capture-MS Homo sapiens
44 HIST1H2BM 8342
Cross-Linking-MS (XL-MS) Homo sapiens
45 C18orf25 147339
Affinity Capture-MS Homo sapiens
46 HIRIP3  
Co-fractionation Homo sapiens
47 CERKL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 STMN1 3925
Co-fractionation Homo sapiens
49 H2AFV 94239
Cross-Linking-MS (XL-MS) Homo sapiens
50 TTC1 7265
Co-fractionation Homo sapiens
51 PFDN4 5203
Co-fractionation Homo sapiens
52 SRRM2 23524
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
53 GSPT1 2935
Affinity Capture-MS Homo sapiens
54 WDR12 55759
Affinity Capture-MS Homo sapiens
55 H2AFY2 55506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 SYT2  
Affinity Capture-MS Homo sapiens
57 TFEB  
Affinity Capture-MS Homo sapiens
58 ABCE1 6059
Affinity Capture-MS Homo sapiens
59 XPO7 23039
Co-fractionation Homo sapiens
60 IPO8 10526
Co-fractionation Homo sapiens
61 TCEANC2  
Affinity Capture-MS Homo sapiens
62 GRWD1 83743
Affinity Capture-MS Homo sapiens
63 TULP3 7289
Affinity Capture-MS Homo sapiens
64 FAF1 11124
Co-fractionation Homo sapiens
65 PTK7 5754
Co-fractionation Homo sapiens
66 MAPK11  
Co-fractionation Homo sapiens
67 NUDCD1 84955
Affinity Capture-MS Homo sapiens
68 NAP1L4 4676
Affinity Capture-MS Homo sapiens
69 MRPS7 51081
Affinity Capture-MS Homo sapiens
70 MAPK14 1432
Co-fractionation Homo sapiens
71 HUWE1 10075
Affinity Capture-MS Homo sapiens
72 ARHGEF39 84904
Affinity Capture-MS Homo sapiens
73 USP7 7874
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
74 SARS 6301
Co-fractionation Homo sapiens
75 UGP2 7360
Co-fractionation Homo sapiens
76 AHCYL1 10768
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
77 SPR 6697
Co-fractionation Homo sapiens
78 MED4 29079
Co-fractionation Homo sapiens
79 FAS 355
Proximity Label-MS Homo sapiens
80 MTNR1B  
Reconstituted Complex Homo sapiens
81 HEXIM1 10614
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
82 E2F4  
Affinity Capture-MS Homo sapiens
83 CPA6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 LINC01588  
Affinity Capture-MS Homo sapiens
85 CARS 833
Co-fractionation Homo sapiens
86 TCOF1 6949
Co-fractionation Homo sapiens
87 SRP9 6726
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 DLD 1738
Affinity Capture-MS Homo sapiens
89 JMJD6 23210
Co-fractionation Homo sapiens
90 PPIB 5479
Cross-Linking-MS (XL-MS) Homo sapiens
91 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 IPO7 10527
Co-fractionation Homo sapiens
93 SRP14 6727
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 SRPK2 6733
Co-fractionation Homo sapiens
95 TRIM56 81844
Affinity Capture-MS Homo sapiens
96 MAP1B 4131
Co-fractionation Homo sapiens
97 COPE 11316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 PHF14 9678
Affinity Capture-MS Homo sapiens
99 NUP50 10762
Proximity Label-MS Homo sapiens
100 COPG1 22820
Affinity Capture-MS Homo sapiens
101 PLD1 5337
Affinity Capture-MS Homo sapiens
102 LRIF1  
Affinity Capture-MS Homo sapiens
103 COPB1 1315
Affinity Capture-MS Homo sapiens
104 CBX3 11335
Proximity Label-MS Homo sapiens
105 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
106 SP110  
Affinity Capture-MS Homo sapiens
107 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 DIRAS3  
Proximity Label-MS Homo sapiens
109 BARD1 580
Affinity Capture-MS Homo sapiens
110 NTRK1 4914
Affinity Capture-MS Homo sapiens
111 RPL31 6160
Proximity Label-MS Homo sapiens
112 SAR1B 51128
Affinity Capture-MS Homo sapiens
113 IFI16 3428
Affinity Capture-MS Homo sapiens
114 XRCC5 7520
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
115 SIX5  
Affinity Capture-MS Homo sapiens
116 DNAJA1 3301
Co-fractionation Homo sapiens
117 PKN1 5585
Co-fractionation Homo sapiens
118 TTC9C 283237
Co-fractionation Homo sapiens
119 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
120 SBK1  
Co-fractionation Homo sapiens
121 GMPS 8833
Affinity Capture-MS Homo sapiens
122 PSMD2 5708
Affinity Capture-MS Homo sapiens
123 Ksr1  
Affinity Capture-MS Mus musculus
124 EIF3I 8668
Co-fractionation Homo sapiens
125 SRPK1 6732
Co-fractionation Homo sapiens
126 PAIP1 10605
Co-fractionation Homo sapiens
127 CT45A5  
Affinity Capture-MS Homo sapiens
128 HIST1H2BJ 8970
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 RPS6KA1 6195
Two-hybrid Homo sapiens
130 CD3EAP  
Proximity Label-MS Homo sapiens
131 RECQL4  
Affinity Capture-MS Homo sapiens
132 YEATS4  
Affinity Capture-MS Homo sapiens
133 TPX2  
Affinity Capture-MS Homo sapiens
134 HIST1H2BL 8340
Affinity Capture-MS Homo sapiens
135 MIER1  
Affinity Capture-MS Homo sapiens
136 SGPL1 8879
Affinity Capture-MS Homo sapiens
137 S100P 6286
Co-fractionation Homo sapiens
138 C11orf31  
Affinity Capture-MS Homo sapiens
139 HADHB 3032
Co-fractionation Homo sapiens
140 RCC1 1104
Affinity Capture-MS Homo sapiens
141 DAP3 7818
Affinity Capture-MS Homo sapiens
142 SPHK1 8877
Affinity Capture-MS Homo sapiens
143 STMN2  
Co-fractionation Homo sapiens
144 POP1 10940
Affinity Capture-MS Homo sapiens
145 ILKAP 80895
Affinity Capture-MS Homo sapiens
146 ECT2 1894
Affinity Capture-MS Homo sapiens
147 SRXN1 140809
Co-fractionation Homo sapiens
148 SIRT7  
Affinity Capture-MS Homo sapiens
149 TAL1  
Proximity Label-MS Homo sapiens
150 AURKA 6790
Affinity Capture-MS Homo sapiens
151 HSPH1 10808
Co-fractionation Homo sapiens
152 NSUN2 54888
Affinity Capture-MS Homo sapiens
153 CD274 29126
Affinity Capture-MS Homo sapiens
154 KPNB1 3837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
155 SHMT2 6472
Affinity Capture-MS Homo sapiens
156 CUL3 8452
Affinity Capture-MS Homo sapiens
157 DACH1  
Affinity Capture-MS Homo sapiens
158 DNAJC17  
Proximity Label-MS Homo sapiens
159 H1F0 3005
Co-fractionation Homo sapiens
160 HTR2C  
Affinity Capture-MS Homo sapiens
161 NAP1L1 4673
Affinity Capture-MS Homo sapiens
162 BAP1 8314
Affinity Capture-MS Homo sapiens
163 ZNF223  
Affinity Capture-MS Homo sapiens
164 BASP1 10409
Co-fractionation Homo sapiens
165 HIST3H3 8290
Protein-peptide Homo sapiens
166 CAND1 55832
Co-fractionation Homo sapiens
167 EFTUD2 9343
Affinity Capture-MS Homo sapiens
168 HADHA 3030
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
169 ARHGAP25  
Affinity Capture-MS Homo sapiens
170 POLR1E  
Proximity Label-MS Homo sapiens
171 IRF5  
Affinity Capture-MS Homo sapiens
172 HIST1H2BA 255626
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
173 MSL1 339287
Two-hybrid Homo sapiens
174 DNAJC9 23234
Affinity Capture-MS Homo sapiens
175 APEH 327
Co-fractionation Homo sapiens
176 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
177 MAGEF1  
Affinity Capture-MS Homo sapiens
178 MYO9B 4650
Affinity Capture-MS Homo sapiens
179 TNS2 23371
Affinity Capture-MS Homo sapiens
180 HSPA4 3308
Co-fractionation Homo sapiens
181 PPAN 56342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
182 STAT6 6778
Co-fractionation Homo sapiens
183 COPA 1314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
184 H2AFB2  
Affinity Capture-MS Homo sapiens
185 PUS1 80324
Affinity Capture-MS Homo sapiens
186 HMG20A  
Affinity Capture-MS Homo sapiens
187 FOXK1 221937
Affinity Capture-MS Homo sapiens
188 HIST1H2BI 8346
Affinity Capture-MS Homo sapiens
189 SUPT16H 11198
Affinity Capture-MS Homo sapiens
190 PYHIN1  
Affinity Capture-MS Homo sapiens
191 ZNF263  
Affinity Capture-MS Homo sapiens
192 OAS3 4940
Affinity Capture-MS Homo sapiens
193 RSBN1L  
Affinity Capture-MS Homo sapiens
194 C3orf17  
Affinity Capture-MS Homo sapiens
195 H2AFX 3014
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 U2SURP 23350
Affinity Capture-MS Homo sapiens
197 DDX46 9879
Cross-Linking-MS (XL-MS) Homo sapiens
198 AHSA1 10598
Affinity Capture-Western Homo sapiens
199 CDC25A  
Affinity Capture-MS Homo sapiens
200 WNK3  
Affinity Capture-MS Homo sapiens
201 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
202 COPZ1 22818
Affinity Capture-MS Homo sapiens
203 TERF2  
Two-hybrid Homo sapiens
204 RBM45  
Affinity Capture-MS Homo sapiens
205 PARP1 142
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
206 USP49 25862
Affinity Capture-MS Homo sapiens
207 DNAJC19 131118
Affinity Capture-MS Homo sapiens
208 FBXL6  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
209 COPS2 9318
Co-fractionation Homo sapiens
210 MAP1S 55201
Affinity Capture-MS Homo sapiens
211 VPS52 6293
Affinity Capture-MS Homo sapiens
212 ZEB1  
Affinity Capture-MS Homo sapiens
213 ARCN1 372
Affinity Capture-MS Homo sapiens
214 SULT1A1 6817
Co-fractionation Homo sapiens
215 HIST2H2AA3 8337
Affinity Capture-MS Homo sapiens
216 THOP1 7064
Co-fractionation Homo sapiens
217 KPNA6 23633
Affinity Capture-MS Homo sapiens
218 CDC27 996
Co-fractionation Homo sapiens
219 THRAP3 9967
Co-fractionation Homo sapiens
220 UBE2C 11065
Co-fractionation Homo sapiens
221 GON4L  
Affinity Capture-MS Homo sapiens
222 HIST1H2BD 3017
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
223 H2AFB3  
Affinity Capture-MS Homo sapiens
224 NIFK 84365
Proximity Label-MS Homo sapiens
225 LARP7 51574
Affinity Capture-MS Homo sapiens
226 WBP11  
Co-fractionation Homo sapiens
227 PSMA1 5682
Co-fractionation Homo sapiens
228 GARS 2617
Co-fractionation Homo sapiens
229 WWP2 11060
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
230 RBM4 5936
Affinity Capture-MS Homo sapiens
231 CEBPA  
Proximity Label-MS Homo sapiens
232 TERF1 7013
Two-hybrid Homo sapiens
233 RPS24 6229
Proximity Label-MS Homo sapiens
234 HIST2H2AA4 723790
Affinity Capture-MS Homo sapiens
235 ARHGAP36  
Affinity Capture-MS Homo sapiens
236 H2AFZ 3015
Affinity Capture-MS Homo sapiens
237 C16orf72 29035
Affinity Capture-MS Homo sapiens
238 TRIM28 10155
Affinity Capture-MS Homo sapiens
239 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
240 KYNU  
Co-fractionation Homo sapiens
241 XRCC6 2547
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
242 ITGA9 3680
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
243 SNX12 29934
Co-fractionation Homo sapiens
244 DNAJC1 64215
Affinity Capture-MS Homo sapiens
245 HIST1H2AH 85235
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
246 C9orf72  
Affinity Capture-MS Homo sapiens
247 SERBP1 26135
Affinity Capture-MS Homo sapiens
248 RPL36AL 6166
Affinity Capture-MS Homo sapiens
249 PTRF 284119
Co-fractionation Homo sapiens
250 PSMC4 5704
Affinity Capture-MS Homo sapiens
251 FBXO38 81545
Two-hybrid Homo sapiens
252 RPA3 6119
Proximity Label-MS Homo sapiens
253 FBXL17  
Affinity Capture-MS Homo sapiens
254 LOC388882  
Affinity Capture-MS Homo sapiens
255 RN7SK 125050
Reconstituted Complex Homo sapiens
256 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
257 EP300 2033
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PPM1G is involved
No pathways found





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