Experiment description of studies that identified PPAN in sEVs

1 Experiment ID 235 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|Alix|HSC70|GAPDH Enriched markers ✔ HSP90B1 Negative markers ✔ qNano Particle analysis Identified molecule mRNA Identification method RNA Sequencing PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N" Journal name Carcinogenesis Publication year 2015 Sample Hepatocellular carcinoma cells Sample name HKCI-8 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RT-PCR RNA Sequencing

2 Experiment ID 236 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|Alix|HSC70|GAPDH Enriched markers ✔ HSP90B1 Negative markers ✔ qNano Particle analysis Identified molecule mRNA Identification method RNA Sequencing PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N" Journal name Carcinogenesis Publication year 2015 Sample Hepatocellular carcinoma cells Sample name MHCC97L Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RT-PCR RNA Sequencing

Protein-protein interactions for PPAN

Protein Interactor ExoCarta ID Identification method PubMed Species 1 GNL2 29889 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 2 UBE2H 7328 Affinity Capture-MS Homo sapiens 3 RIT1 6016 Negative Genetic Homo sapiens 4 TIMM23 100287932 Co-localization Homo sapiens 5 RPL26L1 51121 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 6 ZNF16   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 7 ZNF771   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 8 CLRN3 119467 Cross-Linking-MS (XL-MS) Homo sapiens 9 RPS3A 6189 Affinity Capture-MS Homo sapiens 10 KIAA0020 9933 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 11 RSL24D1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 12 RPL37A 6168 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 13 NOP56 10528 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 14 NMNAT1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 15 NGRN   Affinity Capture-MS Homo sapiens 16 KIF20A 10112 Affinity Capture-MS Homo sapiens 17 PPAN-P2RY11   Affinity Capture-MS Homo sapiens 18 CSNK2A1 1457 Biochemical Activity Homo sapiens 19 CAND1 55832 Affinity Capture-MS Homo sapiens 20 DIEXF   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 21 SOX2   Proximity Label-MS Homo sapiens 22 APP 351 Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens 23 USP36   Affinity Capture-MS Homo sapiens 24 MRPS10 55173 Affinity Capture-MS Homo sapiens 25 IGF2BP3 10643 Affinity Capture-MS Homo sapiens 26 TFAM 7019 Affinity Capture-MS Homo sapiens 27 DDX24 57062 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 28 SF3B1 23451 Affinity Capture-MS Homo sapiens 29 NUFIP1   Affinity Capture-MS Homo sapiens 30 PRC1 9055 Affinity Capture-MS Homo sapiens 31 MRPS23 51649 Affinity Capture-MS Homo sapiens 32 KLF6   Proximity Label-MS Homo sapiens 33 KLF15   Proximity Label-MS Homo sapiens 34 OBSL1 23363 Affinity Capture-MS Homo sapiens 35 ZBTB11   Affinity Capture-MS Homo sapiens 36 PAK1IP1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 37 ZNF644   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 38 SRP68 6730 Affinity Capture-MS Homo sapiens 39 DDX18 8886 Affinity Capture-MS Homo sapiens 40 ATG16L1 55054 Affinity Capture-MS Homo sapiens 41 MRPS7 51081 Affinity Capture-MS Homo sapiens 42 Eif3a 13669 Affinity Capture-MS Mus musculus 43 CUL1 8454 Affinity Capture-MS Homo sapiens 44 MYCN   Affinity Capture-MS Homo sapiens 45 CSNK2B 1460 Affinity Capture-MS Homo sapiens 46 DDX54 79039 Affinity Capture-MS Homo sapiens 47 ZNF184   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 48 KIF14 9928 Affinity Capture-MS Homo sapiens 49 LIN28A   Affinity Capture-MS Homo sapiens 50 BRIX1 55299 Affinity Capture-MS Homo sapiens 51 RB1 5925 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 52 MRPL13   Affinity Capture-MS Homo sapiens 53 KIFC1 3833 Affinity Capture-MS Homo sapiens 54 SRP9 6726 Affinity Capture-MS Homo sapiens 55 TLX3   Proximity Label-MS Homo sapiens 56 RBM28 55131 Affinity Capture-MS Homo sapiens 57 TARBP2   Affinity Capture-MS Homo sapiens 58 DRG1 4733 Affinity Capture-MS Homo sapiens 59 RRP9 9136 Affinity Capture-MS Homo sapiens 60 YBX2 51087 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 61 STAU1 6780 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 62 ZNF22   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 63 STAU2 27067 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 64 UBR5 51366 Affinity Capture-MS Homo sapiens 65 RSL1D1 26156 Affinity Capture-MS Homo sapiens 66 IFI16 3428 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 67 ZNF354A   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 68 REXO4   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 69 NCL 4691 Affinity Capture-MS Homo sapiens 70 DICER1   Affinity Capture-MS Homo sapiens 71 HIST1H1C 3006 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 72 MRPL3   Affinity Capture-MS Homo sapiens 73 HECTD1 25831 Affinity Capture-MS Homo sapiens 74 TCF25 22980 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 75 PPM1G 5496 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 76 GTPBP4 23560 Affinity Capture-MS Homo sapiens 77 LARP1 23367 Affinity Capture-MS Homo sapiens 78 WDR46   Affinity Capture-MS Homo sapiens 79 RRP8   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 80 TLX2   Proximity Label-MS Homo sapiens 81 MRPS35 60488 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 82 EIF6 3692 Affinity Capture-MS Homo sapiens 83 SMARCA5 8467 Affinity Capture-MS Homo sapiens 84 ZBTB24   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 85 RPL3 6122 Affinity Capture-MS Homo sapiens 86 NR3C1 2908 Proximity Label-MS Homo sapiens 87 ISG20L2 81875 Affinity Capture-MS Homo sapiens 88 PAPD5 64282 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 89 DHX30 22907 Affinity Capture-MS Homo sapiens 90 RRP15   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 91 ZCCHC7   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 92 SOX15   Proximity Label-MS Homo sapiens 93 PCBP1 5093 Affinity Capture-MS Homo sapiens 94 DKC1 1736 Affinity Capture-MS Homo sapiens 95 MYC   Affinity Capture-MS Homo sapiens 96 RPA3 6119 Proximity Label-MS Homo sapiens 97 RPS13 6207 Affinity Capture-MS Homo sapiens 98 SET 6418 Affinity Capture-MS Homo sapiens 99 GZF1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 100 HP1BP3 50809 Affinity Capture-MS Homo sapiens 101 MOV10 4343 Affinity Capture-MS Homo sapiens 102 DDRGK1 65992 Affinity Capture-MS Homo sapiens 103 FYTTD1   Affinity Capture-MS Homo sapiens 104 ZFP62   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 105 Eif3e 16341 Affinity Capture-MS Mus musculus 106 FTSJ3 117246 Affinity Capture-MS Homo sapiens 107 MDM2   Affinity Capture-MS Homo sapiens 108 GNL3 26354 Affinity Capture-MS Homo sapiens 109 RPS16 6217 Affinity Capture-MS Homo sapiens 110 ZNF574   Affinity Capture-MS Homo sapiens 111 PRDM10   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 112 SIRT6   Affinity Capture-MS Homo sapiens 113 WDR77 79084 Affinity Capture-MS Homo sapiens 114 NOL10   Affinity Capture-MS Homo sapiens 115 MNDA 4332 Affinity Capture-MS Homo sapiens 116 MRPS31   Affinity Capture-MS Homo sapiens 117 KNOP1 400506 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 118 SMNDC1   Affinity Capture-MS Homo sapiens 119 HIST1H2BD 3017 Affinity Capture-MS Homo sapiens 120 TAF1D   Affinity Capture-MS Homo sapiens 121 RPL15 6138 Affinity Capture-MS Homo sapiens 122 MKI67   Affinity Capture-MS Homo sapiens 123 REPIN1   Affinity Capture-MS Homo sapiens 124 DDX27 55661 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 125 ZNF317 57693 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 126 KRR1 11103 Affinity Capture-MS Homo sapiens 127 ZNF496   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 128 YBX3 8531 Affinity Capture-MS Homo sapiens 129 UPF1 5976 Affinity Capture-MS Homo sapiens 130 CIT 11113 Affinity Capture-MS Homo sapiens 131 GLYR1 84656 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 132 CUL7 9820 Affinity Capture-MS Homo sapiens 133 KRAS 3845 Negative Genetic Homo sapiens 134 GNB2L1 10399 Affinity Capture-MS Homo sapiens 135 STRBP 55342 Affinity Capture-MS Homo sapiens 136 NVL   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 137 DDX56   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 138 ZSCAN25   Affinity Capture-MS Homo sapiens 139 ZNF770 54989 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 140 EP300 2033 Affinity Capture-MS Homo sapiens View the network

Pathways in which PPAN is involved

No pathways found