Gene description for ARHGEF39
Gene name Rho guanine nucleotide exchange factor (GEF) 39
Gene symbol ARHGEF39
Other names/aliases C9orf100
Species Homo sapiens
 Database cross references - ARHGEF39
ExoCarta ExoCarta_84904
Vesiclepedia VP_84904
Entrez Gene 84904
HGNC 25909
UniProt Q8N4T4  
 ARHGEF39 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ARHGEF39
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of cell migration GO:0030335 IBA
    positive regulation of cell migration GO:0030335 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified ARHGEF39 in sEVs
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARHGEF39
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PA2G4 5036
Affinity Capture-MS Homo sapiens
2 FTL 2512
Affinity Capture-MS Homo sapiens
3 LBR 3930
Affinity Capture-MS Homo sapiens
4 NME2 4831
Affinity Capture-MS Homo sapiens
5 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
6 SLIRP 81892
Affinity Capture-MS Homo sapiens
7 ANKFY1 51479
Affinity Capture-MS Homo sapiens
8 CSDE1 7812
Affinity Capture-MS Homo sapiens
9 TIFA  
Two-hybrid Homo sapiens
10 RBPMS 11030
Two-hybrid Homo sapiens
11 ANP32A 8125
Affinity Capture-MS Homo sapiens
12 DVL2 1856
Two-hybrid Homo sapiens
13 PEX13  
Affinity Capture-MS Homo sapiens
14 TRAF4 9618
Affinity Capture-MS Homo sapiens
15 IMPDH1 3614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 PRDX4 10549
Affinity Capture-MS Homo sapiens
17 ACAA1 30
Affinity Capture-MS Homo sapiens
18 ZYX 7791
Affinity Capture-MS Homo sapiens
19 NUP93 9688
Affinity Capture-MS Homo sapiens
20 CAMK2A 815
Affinity Capture-MS Homo sapiens
21 ZNF703  
Affinity Capture-MS Homo sapiens
22 KCTD12 115207
Affinity Capture-MS Homo sapiens
23 MEX3A  
Affinity Capture-RNA Homo sapiens
24 PFDN1 5201
Affinity Capture-MS Homo sapiens
25 SSB 6741
Affinity Capture-MS Homo sapiens
26 CSTA 1475
Affinity Capture-MS Homo sapiens
27 KPNA2 3838
Affinity Capture-MS Homo sapiens
28 TYSND1  
Affinity Capture-MS Homo sapiens
29 XRN2 22803
Affinity Capture-MS Homo sapiens
30 SNRPF 6636
Affinity Capture-MS Homo sapiens
31 BOLA2 552900
Affinity Capture-MS Homo sapiens
32 PSMD14 10213
Affinity Capture-MS Homo sapiens
33 HNRNPH2 3188
Affinity Capture-MS Homo sapiens
34 RANGAP1 5905
Affinity Capture-MS Homo sapiens
35 FUBP1 8880
Affinity Capture-MS Homo sapiens
36 SEC16A 9919
Affinity Capture-MS Homo sapiens
37 PFDN6 10471
Affinity Capture-MS Homo sapiens
38 SSSCA1 10534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 HNRNPF 3185
Affinity Capture-MS Homo sapiens
40 CACNG5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 NSRP1  
Affinity Capture-MS Homo sapiens
42 DDB1 1642
Affinity Capture-MS Homo sapiens
43 PTGES3 10728
Affinity Capture-MS Homo sapiens
44 Tagap  
Affinity Capture-MS Mus musculus
45 CALCOCO2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
46 SLC31A1 1317
Affinity Capture-MS Homo sapiens
47 CTH 1491
Affinity Capture-MS Homo sapiens
48 HEATR1 55127
Affinity Capture-MS Homo sapiens
49 ARHGEF10 9639
Affinity Capture-MS Homo sapiens
50 AASS  
Affinity Capture-MS Homo sapiens
51 PPM1G 5496
Affinity Capture-MS Homo sapiens
52 FARSA 2193
Affinity Capture-MS Homo sapiens
53 PIPSL 266971
Affinity Capture-MS Homo sapiens
54 BCR 613
Affinity Capture-MS Homo sapiens
55 CKMT1B 1159
Affinity Capture-MS Homo sapiens
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