Gene description for MSL1
Gene name male-specific lethal 1 homolog (Drosophila)
Gene symbol MSL1
Other names/aliases MSL-1
hMSL1
Species Homo sapiens
 Database cross references - MSL1
ExoCarta ExoCarta_339287
Vesiclepedia VP_339287
Entrez Gene 339287
HGNC 27905
MIM 614801
UniProt Q68DK7  
 MSL1 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for MSL1
Molecular Function
    protein binding GO:0005515 IPI
    protein-macromolecule adaptor activity GO:0030674 IDA
Biological Process
    chromatin remodeling GO:0006338 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 ISO
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nuclear speck GO:0016607 ISS
    MSL complex GO:0072487 IBA
    MSL complex GO:0072487 IDA
 Experiment description of studies that identified MSL1 in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for MSL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MSL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
2 HORMAD1  
Two-hybrid Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
4 HBB 3043
Affinity Capture-MS Homo sapiens
5 MSL3P1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 RNF40 9810
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
7 FASN 2194
Negative Genetic Homo sapiens
8 GMNN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 WDR5 11091
Affinity Capture-MS Homo sapiens
10 CRKL 1399
Two-hybrid Homo sapiens
11 MSL3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TP53BP1 7158
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
13 H2AFZ 3015
Affinity Capture-MS Homo sapiens
14 SMARCC1 6599
Two-hybrid Homo sapiens
15 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
16 MEX3A  
Affinity Capture-RNA Homo sapiens
17 PBK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
19 HSPB1 3315
Two-hybrid Homo sapiens
20 YY1 7528
Proximity Label-MS Homo sapiens
21 MRGBP  
Two-hybrid Homo sapiens
22 RNF20 56254
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
23 MORF4L1  
Two-hybrid Homo sapiens
24 FAM96B 51647
Affinity Capture-MS Homo sapiens
25 NXF1 10482
Affinity Capture-RNA Homo sapiens
26 Kat8  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
27 AHCYL2 23382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 NUPR1  
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
29 MOV10 4343
Affinity Capture-RNA Homo sapiens
30 IBTK 25998
Affinity Capture-MS Homo sapiens
31 CNTROB  
Affinity Capture-MS Homo sapiens
32 FCHSD2  
Two-hybrid Homo sapiens
33 CDK9 1025
Co-fractionation Homo sapiens
34 FRA10AC1 118924
Affinity Capture-MS Homo sapiens
35 PNMA2  
Affinity Capture-MS Homo sapiens
36 PARP1 142
Affinity Capture-MS Homo sapiens
37 KPNB1 3837
Two-hybrid Homo sapiens
38 SNW1 22938
Two-hybrid Homo sapiens
39 KAT8  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 ARID1A 8289
Negative Genetic Homo sapiens
41 UBE2D3 7323
Reconstituted Complex Homo sapiens
42 PAF1 54623
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
43 NUCKS1 64710
Affinity Capture-MS Homo sapiens
44 HMGA1 3159
Affinity Capture-MS Homo sapiens
45 PPM1G 5496
Two-hybrid Homo sapiens
46 SLC33A1 9197
Affinity Capture-MS Homo sapiens
47 RAN 5901
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MSL1 is involved
PathwayEvidenceSource
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
HATs acetylate histones TAS Reactome





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