Gene description for TNN
Gene name tenascin N
Gene symbol TNN
Other names/aliases TN-W
Species Homo sapiens
 Database cross references - TNN
ExoCarta ExoCarta_63923
Vesiclepedia VP_63923
Entrez Gene 63923
HGNC 22942
UniProt Q9UQP3  
 TNN identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TNN
Molecular Function
    integrin binding GO:0005178 IBA
    identical protein binding GO:0042802 IEA
Biological Process
    osteoblast development GO:0002076 ISS
    cell-matrix adhesion GO:0007160 IBA
    axonogenesis GO:0007409 IEA
    positive regulation of neuron projection development GO:0010976 ISO
    regulation of cell adhesion GO:0030155 IDA
    regulation of cell migration GO:0030334 IDA
    negative regulation of osteoblast proliferation GO:0033689 ISS
    negative regulation of osteoblast differentiation GO:0045668 ISS
    dendrite self-avoidance GO:0070593 ISA
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISS
    regulation of bone development GO:1903010 ISO
    positive regulation of sprouting angiogenesis GO:1903672 IDA
    regulation of smooth muscle tissue development GO:1905899 ISO
    neuron projection extension GO:1990138 IBA
    negative regulation of neuron migration GO:2001223 ISA
Subcellular Localization
    extracellular space GO:0005615 IBA
    cell surface GO:0009986 IEA
    neuronal cell body GO:0043025 IEA
    collagen-containing extracellular matrix GO:0062023 IBA
    collagen-containing extracellular matrix GO:0062023 IDA
    tenascin complex GO:0090733 IPI
    CA3 pyramidal cell dendrite GO:0097442 IEA
    hippocampal mossy fiber expansion GO:1990026 IEA
 Experiment description of studies that identified TNN in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TNN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST1H2BJ 8970
Cross-Linking-MS (XL-MS) Homo sapiens
2 HIST1H2BB 3018
Cross-Linking-MS (XL-MS) Homo sapiens
3 HIST2H2BF 440689
Cross-Linking-MS (XL-MS) Homo sapiens
4 ACTN2 88
Reconstituted Complex Homo sapiens
5 HIST2H2BE 8349
Cross-Linking-MS (XL-MS) Homo sapiens
6 PSME2 5721
Co-fractionation Homo sapiens
7 ACOT13  
Co-fractionation Homo sapiens
8 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
9 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
10 LOC102724334 102724334
Cross-Linking-MS (XL-MS) Homo sapiens
11 HIST1H2BO 8348
Cross-Linking-MS (XL-MS) Homo sapiens
12 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
13 HIST1H2BN 8341
Cross-Linking-MS (XL-MS) Homo sapiens
14 DPPA2  
Cross-Linking-MS (XL-MS) Homo sapiens
15 PSPC1 55269
Co-fractionation Homo sapiens
16 HIST3H2BB 128312
Cross-Linking-MS (XL-MS) Homo sapiens
17 HIST1H2BA 255626
Cross-Linking-MS (XL-MS) Homo sapiens
18 DUOX2 50506
Cross-Linking-MS (XL-MS) Homo sapiens
19 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
20 HIST1H2BM 8342
Cross-Linking-MS (XL-MS) Homo sapiens
21 HCLS1 3059
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which TNN is involved
PathwayEvidenceSource
ECM proteoglycans TAS Reactome
Extracellular matrix organization TAS Reactome





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