Gene description for TOR1A
Gene name torsin family 1, member A (torsin A)
Gene symbol TOR1A
Other names/aliases DQ2
DYT1
Species Homo sapiens
 Database cross references - TOR1A
ExoCarta ExoCarta_1861
Vesiclepedia VP_1861
Entrez Gene 1861
HGNC 3098
MIM 605204
UniProt O14656  
 TOR1A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Saliva 19199708    
 Gene ontology annotations for TOR1A
Molecular Function
    DNA clamp loader activity GO:0003689 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    cytoskeletal protein binding GO:0008092 IPI
    ATP hydrolysis activity GO:0016887 IDA
    kinesin binding GO:0019894 IBA
    kinesin binding GO:0019894 IPI
    identical protein binding GO:0042802 IMP
    identical protein binding GO:0042802 IPI
    unfolded protein binding GO:0051082 TAS
    misfolded protein binding GO:0051787 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent protein folding chaperone GO:0140662 IDA
    ATP-dependent protein folding chaperone GO:0140662 IMP
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    protein deneddylation GO:0000338 IMP
    chromatin remodeling GO:0006338 IEA
    response to oxidative stress GO:0006979 IEA
    nuclear envelope organization GO:0006998 ISS
    cell adhesion GO:0007155 IMP
    neuron projection development GO:0031175 IMP
    protein localization to nucleus GO:0034504 IBA
    protein localization to nucleus GO:0034504 IMP
    protein localization to nucleus GO:0034504 ISS
    ERAD pathway GO:0036503 ISS
    wound healing, spreading of cells GO:0044319 ISS
    intermediate filament cytoskeleton organization GO:0045104 IMP
    synaptic vesicle transport GO:0048489 IMP
    synaptic vesicle membrane organization GO:0048499 IMP
    chaperone cofactor-dependent protein refolding GO:0051085 IEA
    regulation of dopamine uptake involved in synaptic transmission GO:0051584 IDA
    chaperone-mediated protein folding GO:0061077 IDA
    nuclear membrane organization GO:0071763 IBA
    nuclear membrane organization GO:0071763 ISS
    chromatin looping GO:0140588 IEA
    positive regulation of synaptic vesicle endocytosis GO:1900244 IMP
    regulation of protein localization to cell surface GO:2000008 IMP
Subcellular Localization
    nuclear envelope GO:0005635 IBA
    nuclear envelope GO:0005635 ISS
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum lumen GO:0005788 IBA
    endoplasmic reticulum lumen GO:0005788 IDA
    endoplasmic reticulum membrane GO:0005789 IDA
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IEA
    synaptic vesicle GO:0008021 IDA
    membrane GO:0016020 IDA
    secretory granule GO:0030141 ISS
    growth cone GO:0030426 ISS
    cytoplasmic vesicle membrane GO:0030659 ISS
    nuclear membrane GO:0031965 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified TOR1A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 66
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG101|Alix|CD63|CD81
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for TOR1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRTAP10-7  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 RPA2 6118
Proximity Label-MS Homo sapiens
3 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SNCA 6622
FRET Homo sapiens
5 TOR2A 27433
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TMEM106A  
Affinity Capture-MS Homo sapiens
7 CLIC1 1192
Co-fractionation Homo sapiens
8 TOR1A 1861
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
9 CLGN 1047
Affinity Capture-MS Homo sapiens
10 CLEC3A  
Affinity Capture-MS Homo sapiens
11 CANX 821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 HSD11B1 3290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TOR1AIP2 163590
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
14 C1GALT1C1 29071
Affinity Capture-MS Homo sapiens
15 PRPH2 5961
Affinity Capture-MS Homo sapiens
16 CALR3  
Proximity Label-MS Homo sapiens
17 PIP 5304
Affinity Capture-MS Homo sapiens
18 TOR3A 64222
Affinity Capture-MS Homo sapiens
19 HPN  
Affinity Capture-MS Homo sapiens
20 LRRC59 55379
Proximity Label-MS Homo sapiens
21 GGH 8836
Affinity Capture-MS Homo sapiens
22 STON2 85439
Affinity Capture-Western Homo sapiens
23 MDFI  
Two-hybrid Homo sapiens
24 TOR1B 27348
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
25 BRD2  
Affinity Capture-MS Homo sapiens
26 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
27 SNAPIN 23557
Affinity Capture-Western Homo sapiens
28 CLU 1191
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 TOR1AIP1 26092
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
30 BRI3BP 140707
Affinity Capture-MS Homo sapiens
31 FAM20B 9917
Affinity Capture-MS Homo sapiens
32 APOD 347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
34 AURKB 9212
Affinity Capture-MS Homo sapiens
35 KIAA1429 25962
Affinity Capture-MS Homo sapiens
36 BTF3 689
Affinity Capture-MS Homo sapiens
37 Sgce  
Affinity Capture-Western Mus musculus
38 RMDN3 55177
Affinity Capture-MS Homo sapiens
39 CNIH4  
Affinity Capture-MS Homo sapiens
40 SDF2L1 23753
Affinity Capture-MS Homo sapiens
41 DHCR7 1717
Affinity Capture-MS Homo sapiens
42 CGREF1 10669
Affinity Capture-MS Homo sapiens
43 FBXO2 26232
Affinity Capture-Western Homo sapiens
44 MGST3 4259
Affinity Capture-MS Homo sapiens
45 ATP2B2 491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ASPHD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 DNAJC3 5611
Proximity Label-MS Homo sapiens
48 CUL7 9820
Affinity Capture-MS Homo sapiens
49 METTL9 51108
Affinity Capture-MS Homo sapiens
50 BAGE2  
Affinity Capture-MS Homo sapiens
51 ST14 6768
Affinity Capture-MS Homo sapiens
52 COPS4 51138
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
53 TEX29  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 LMNA 4000
Reconstituted Complex Homo sapiens
55 RPA3 6119
Proximity Label-MS Homo sapiens
56 BRD3 8019
Affinity Capture-MS Homo sapiens
57 SEC61B 10952
Proximity Label-MS Homo sapiens
58 TMPRSS13  
Affinity Capture-MS Homo sapiens
59 RER1 11079
Affinity Capture-MS Homo sapiens
60 BRD4 23476
Affinity Capture-MS Homo sapiens
61 H2AFX 3014
Affinity Capture-MS Homo sapiens
62 KLHL14 57565
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
View the network image/svg+xml



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