ExoCarta: Gene summary

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Gene description for FBXO2
Gene name	F-box protein 2
Gene symbol	FBXO2
Other names/aliases	FBG1 FBX2 Fbs1 NFB42 OCP1
Species	Homo sapiens
Database cross references - FBXO2
ExoCarta	ExoCarta_26232
Vesiclepedia	VP_26232
Entrez Gene	26232
HGNC	13581
MIM	607112
UniProt	Q9UK22
FBXO2 identified in sEVs derived from the following tissue/cell type
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Hepatocytes	26054723
Thymus	23844026

Gene ontology annotations for FBXO2

Molecular Function
	amyloid-beta binding	GO:0001540	IEA
	ubiquitin-protein transferase activity	GO:0004842	TAS
	protein binding	GO:0005515	IPI
	carbohydrate binding	GO:0030246	IEA
	denatured protein binding	GO:0031249	IEA
	ubiquitin protein ligase activity	GO:0061630	IBA
Biological Process
	proteolysis	GO:0006508	TAS
	glycoprotein catabolic process	GO:0006516	IBA
	glycoprotein catabolic process	GO:0006516	ISS
	negative regulation of cell population proliferation	GO:0008285	IEA
	protein ubiquitination	GO:0016567	IEA
	protein ubiquitination	GO:0016567	ISS
	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:0031146	IBA
	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:0031146	ISS
	regulation of protein ubiquitination	GO:0031396	IEA
	protein modification process	GO:0036211	TAS
	ERAD pathway	GO:0036503	IBA
	regulation of protein catabolic process at postsynapse, modulating synaptic transmission	GO:0099576	IEA
Subcellular Localization
	cytoplasm	GO:0005737	IBA
	cytoplasm	GO:0005737	IDA
	endoplasmic reticulum	GO:0005783	IEA
	cytosol	GO:0005829	ISS
	cytosol	GO:0005829	TAS
	SCF ubiquitin ligase complex	GO:0019005	IBA
	SCF ubiquitin ligase complex	GO:0019005	ISS
	dendritic spine	GO:0043197	IEA
	extrinsic component of postsynaptic membrane	GO:0098890	IEA
	glutamatergic synapse	GO:0098978	IEA

Experiment description of studies that identified FBXO2 in sEVs

Experiment ID

363

MISEV standards
✘	Biophysical techniques
✔	Enriched markers
✔	Negative markers
✔	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

33991177

Organism

Homo sapiens

Experiment description

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells

Authors

"Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."

Journal name

Proteomics

Publication year

2021

Sample

Gastric cancer cells

Sample name

MKN1 - 100K pellet

Isolation/purification methods

Differential centrifugation
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

364

MISEV standards
✘	Biophysical techniques
✔	Enriched markers
✔	Negative markers
✔	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

33991177

Organism

Homo sapiens

Experiment description

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells

Authors

"Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."

Journal name

Proteomics

Publication year

2021

Sample

Gastric cancer cells

Sample name

MKN1 - 100K pellet

Isolation/purification methods

Differential centrifugation
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

365

MISEV standards
✘	Biophysical techniques
✔	Enriched markers
✔	Negative markers
✔	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

33991177

Organism

Homo sapiens

Experiment description

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells

Authors

"Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."

Journal name

Proteomics

Publication year

2021

Sample

Gastric cancer cells

Sample name

MKN1 - 100K pellet

Isolation/purification methods

Differential centrifugation
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

237

MISEV standards
✔	Biophysical techniques
✔	Enriched markers
✔	Negative markers
✔	Particle analysis

Identified molecule

mRNA

Identification method

RNA Sequencing

PubMed ID

26054723

Organism

Homo sapiens

Experiment description

Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs

Authors

"He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"

Journal name

Carcinogenesis

Publication year

2015

Sample

Hepatocytes

Sample name

MIHA

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient

Flotation density

1.13-1.19 g/mL

Molecules identified in the study

Protein
RNA

Methods used in the study

Western blotting
Mass spectrometry
RNA Sequencing

Experiment ID

217

MISEV standards
✔	Biophysical techniques
✔	Enriched markers
✘	Negative markers
✔	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23844026

Organism

Homo sapiens

Experiment description

Characterization of human thymic exosomes.

Authors

"Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."

Journal name

PLoS One

Publication year

2013

Sample

Thymus

Sample name

Normal-Thymus

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for FBXO2

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

ITGB1

3688

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

AXL

558

Affinity Capture-MS

Homo sapiens

SEMA4D

Affinity Capture-MS

Homo sapiens

NOTCH3

4854

Affinity Capture-MS

Homo sapiens

DAG1

1605

Affinity Capture-MS

Homo sapiens

ENPP4

22875

Affinity Capture-MS

Homo sapiens

POMGNT2

Affinity Capture-MS

Homo sapiens

AMOTL1

154810

Affinity Capture-MS

Homo sapiens

FGFR3

2261

Affinity Capture-MS

Homo sapiens

LAMC1

3915

Affinity Capture-MS

Homo sapiens

HPSE

10855

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SCARA3

Affinity Capture-MS

Homo sapiens

ADGRG1

9289

Affinity Capture-MS

Homo sapiens

GNS

2799

Affinity Capture-MS

Homo sapiens

AMOT

154796

Affinity Capture-MS

Homo sapiens

UNC5B

219699

Affinity Capture-MS

Homo sapiens

NID1

4811

Affinity Capture-MS

Homo sapiens

HEXB

3074

Affinity Capture-MS

Homo sapiens

PLBD2

196463

Affinity Capture-MS

Homo sapiens

ST14

6768

Affinity Capture-MS

Homo sapiens

LAMA4

3910

Affinity Capture-MS

Homo sapiens

SCARB1

949

Affinity Capture-MS

Homo sapiens

CD14

929

Affinity Capture-MS

Homo sapiens

IL17RA

23765

Affinity Capture-MS

Homo sapiens

KPTN

Affinity Capture-MS

Homo sapiens

POMT1

10585

Affinity Capture-MS

Homo sapiens

PFDN6

10471

Two-hybrid

Homo sapiens

SLC12A7

10723

Affinity Capture-MS

Homo sapiens

MEST

4232

Affinity Capture-MS

Homo sapiens

EMC1

23065

Affinity Capture-MS

Homo sapiens

TMEM25

Affinity Capture-MS

Homo sapiens

AMOTL2

51421

Affinity Capture-MS

Homo sapiens

NOMO1

23420

Affinity Capture-MS

Homo sapiens

SHMT1

6470

Affinity Capture-MS

Homo sapiens

PCSK5

5125

Affinity Capture-MS

Homo sapiens

UGT8

Affinity Capture-MS

Homo sapiens

KIAA1161

57462

Affinity Capture-MS

Homo sapiens

MCAM

4162

Affinity Capture-MS

Homo sapiens

TMTC3

160418

Affinity Capture-MS

Homo sapiens

ACP2

Affinity Capture-MS

Homo sapiens

CDHR2

54825

Affinity Capture-MS

Homo sapiens

KDELC2

143888

Affinity Capture-MS

Homo sapiens

PIGT

51604

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CNTN1

1272

Affinity Capture-MS

Homo sapiens

FRAS1

80144

Affinity Capture-MS

Homo sapiens

GRIN1

2902

Affinity Capture-MS

Homo sapiens

B4GALT3

8703

Affinity Capture-MS

Homo sapiens

PLA2G15

23659

Affinity Capture-MS

Homo sapiens

BRAP

Two-hybrid

Homo sapiens

LRP1B

53353

Affinity Capture-MS

Homo sapiens

ADGRV1

84059

Affinity Capture-MS

Homo sapiens

CCDC28A

Affinity Capture-MS

Homo sapiens

EPHB4

2050

Affinity Capture-MS

Homo sapiens

MGMT

4255

Affinity Capture-MS

Homo sapiens

LRIG3

Affinity Capture-MS

Homo sapiens

GJB2

Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

ANO6

196527

Affinity Capture-MS

Homo sapiens

EPDR1

54749

Affinity Capture-MS

Homo sapiens

QSOX1

5768

Affinity Capture-MS

Homo sapiens

CTU1

90353

Affinity Capture-MS

Homo sapiens

IL25

Affinity Capture-MS

Homo sapiens

CHST8

64377

Affinity Capture-MS

Homo sapiens

IQCB1

Affinity Capture-MS

Homo sapiens

ATRN

8455

Affinity Capture-MS

Homo sapiens

SERPINA9

327657

Affinity Capture-MS

Homo sapiens

CLN5

Affinity Capture-MS

Homo sapiens

NAGLU

4669

Affinity Capture-MS

Homo sapiens

FN1

2335

Affinity Capture-MS

Homo sapiens

ITGA1

3672

Affinity Capture-MS

Homo sapiens

PLTP

5360

Affinity Capture-MS

Homo sapiens

JAG2

Affinity Capture-MS

Homo sapiens

PLXNC1

10154

Affinity Capture-MS

Homo sapiens

IGSF3

3321

Affinity Capture-MS

Homo sapiens

NCLN

56926

Affinity Capture-MS

Homo sapiens

GXYLT1

283464

Affinity Capture-MS

Homo sapiens

OPCML

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PVR

5817

Affinity Capture-MS

Homo sapiens

CTSF

8722

Affinity Capture-MS

Homo sapiens

LYRM4

57128

Affinity Capture-MS

Homo sapiens

STUB1

10273

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Biochemical Activity		Homo sapiens

HK2

3099

Affinity Capture-MS

Homo sapiens

TTC13

Affinity Capture-MS

Homo sapiens

NAAA

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ENPP5

Affinity Capture-MS

Homo sapiens

PIEZO1

9780

Affinity Capture-MS

Homo sapiens

CTHRC1

115908

Affinity Capture-MS

Homo sapiens

ASIC5

Affinity Capture-MS

Homo sapiens

EMC7

56851

Affinity Capture-MS

Homo sapiens

ASIC4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CLPTM1

1209

Affinity Capture-MS

Homo sapiens

EMC4

51234

Affinity Capture-MS

Homo sapiens

SKP1

6500

Co-crystal Structure		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens
Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

BOC

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

AGRN

375790

Affinity Capture-MS

Homo sapiens

ITGA2

3673

Affinity Capture-MS

Homo sapiens

ATF6B

Affinity Capture-MS

Homo sapiens

DUOX1

Affinity Capture-MS

Homo sapiens

EMILIN2

84034

Affinity Capture-MS

Homo sapiens

TM2D3

Affinity Capture-MS

Homo sapiens

100

POMK

Affinity Capture-MS

Homo sapiens

101

OLFM2

Affinity Capture-MS

Homo sapiens

102

LAMA5

3911

Affinity Capture-MS

Homo sapiens

103

CUL7

9820

Affinity Capture-Western

Homo sapiens

104

WFS1

7466

Affinity Capture-MS

Homo sapiens

105

RNF157

114804

Affinity Capture-MS

Homo sapiens

106

CTF1

Affinity Capture-MS

Homo sapiens

107

PTGFRN

5738

Affinity Capture-MS

Homo sapiens

108

PIGS

94005

Affinity Capture-MS

Homo sapiens

109

ADAM23

8745

Affinity Capture-MS

Homo sapiens

110

TOR1A

1861

Affinity Capture-Western

Homo sapiens

111

CNTNAP3

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

112

CD48

962

Affinity Capture-MS

Homo sapiens

113

ST6GALNAC5

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

114

KLK5

25818

Affinity Capture-MS

Homo sapiens

115

IDUA

3425

Affinity Capture-MS

Homo sapiens

116

ROCK2

9475

Affinity Capture-MS

Homo sapiens

117

IFNGR1

3459

Affinity Capture-MS

Homo sapiens

118

GPR110

Affinity Capture-MS

Homo sapiens

119

FFAR1

Affinity Capture-MS

Homo sapiens

120

LRP10

26020

Affinity Capture-MS

Homo sapiens

121

CHST10

Affinity Capture-MS

Homo sapiens

122

IL6ST

3572

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

123

B3GNT2

10678

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

124

ADAM9

8754

Affinity Capture-MS

Homo sapiens

125

TMEM231

79583

Affinity Capture-MS

Homo sapiens

126

FGFR4

2264

Affinity Capture-MS

Homo sapiens

127

AMIGO3

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

128

TINAGL1

64129

Affinity Capture-MS

Homo sapiens

129

L1CAM

3897

Affinity Capture-MS

Homo sapiens

130

NID2

22795

Affinity Capture-MS

Homo sapiens

131

EMB

133418

Affinity Capture-MS

Homo sapiens

132

CUL1

8454

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

133

GNPTAB

79158

Affinity Capture-MS

Homo sapiens

134

PXDN

7837

Affinity Capture-MS

Homo sapiens

135

PCYOX1

51449

Affinity Capture-MS

Homo sapiens

136

SLAMF7

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

137

PRNP

5621

Affinity Capture-MS

Homo sapiens

138

SDK2

54549

Affinity Capture-MS

Homo sapiens

139

NPC1

4864

Affinity Capture-MS

Homo sapiens

140

RBX1

9978

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

141

PPT2

Affinity Capture-MS

Homo sapiens

142

HS6ST1

Affinity Capture-MS

Homo sapiens

143

C12orf49

Affinity Capture-MS

Homo sapiens

144

LAG3

Affinity Capture-MS

Homo sapiens

145

EMILIN3

Affinity Capture-MS

Homo sapiens

146

TCTN2

Affinity Capture-MS

Homo sapiens

147

NOMO3

408050

Affinity Capture-MS

Homo sapiens

148

C4BPB

725

Affinity Capture-MS

Homo sapiens

149

TGFBR3

7049

Affinity Capture-MS

Homo sapiens

150

TMEM131

Affinity Capture-MS

Homo sapiens

151

ICAM5

7087

Affinity Capture-MS

Homo sapiens

152

SUSD1

64420

Affinity Capture-MS

Homo sapiens

153

TMED9

54732

Affinity Capture-MS

Homo sapiens

154

MAN2B2

23324

Affinity Capture-MS

Homo sapiens

155

EMC8

10328

Affinity Capture-MS

Homo sapiens

156

TMPRSS11B

132724

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

157

LAMB2

3913

Affinity Capture-MS

Homo sapiens

158

UBE2L3

7332

Reconstituted Complex

Homo sapiens

159

GALNT5

11227

Affinity Capture-MS

Homo sapiens

160

PRCP

5547

Affinity Capture-MS

Homo sapiens

161

LRFN3

Affinity Capture-MS

Homo sapiens

162

LTBP4

8425

Affinity Capture-MS

Homo sapiens

163

EGFR

1956

Affinity Capture-MS

Homo sapiens

164

LEPR

3953

Affinity Capture-MS

Homo sapiens

165

FGFR2

2263

Affinity Capture-MS

Homo sapiens

166

PLXND1

23129

Affinity Capture-MS

Homo sapiens

167

IL12RB1

Affinity Capture-MS

Homo sapiens

168

GIF

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

169

UBE2E1

Reconstituted Complex

Homo sapiens

170

MET

4233

Affinity Capture-MS

Homo sapiens

171

PKD2

5311

Affinity Capture-MS

Homo sapiens

172

ABCA2

Affinity Capture-MS

Homo sapiens

173

PCYOX1L

78991

Affinity Capture-MS

Homo sapiens

174

OSBPL8

114882

Affinity Capture-MS

Homo sapiens

175

IL6R

Affinity Capture-Western

Homo sapiens

176

FBN1

2200

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

177

EDIL3

10085

Affinity Capture-MS

Homo sapiens

178

SUN1

23353

Affinity Capture-MS

Homo sapiens

179

PLXNB2

23654

Affinity Capture-MS

Homo sapiens

180

GRN

2896

Affinity Capture-MS

Homo sapiens

181

TIMP1

7076

Affinity Capture-MS

Homo sapiens

182

BTD

686

Affinity Capture-MS

Homo sapiens

183

CRLF1

9244

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

184

NOTCH2

4853

Affinity Capture-MS

Homo sapiens

185

WNT10B

7480

Affinity Capture-MS

Homo sapiens

186

SEC11A

23478

Affinity Capture-MS

Homo sapiens

187

ADAM33

80332

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

188

SEMA3C

10512

Affinity Capture-MS

Homo sapiens

189

SPINT1

6692

Affinity Capture-MS

Homo sapiens

190

CD47

961

Affinity Capture-MS

Homo sapiens

191

GPR125

Affinity Capture-MS

Homo sapiens

192

PIGU

128869

Affinity Capture-MS

Homo sapiens

193

TOR1AIP1

26092

Affinity Capture-MS

Homo sapiens

194

EDEM2

Affinity Capture-MS

Homo sapiens

195

FOLR3

Affinity Capture-MS

Homo sapiens

196

MINPP1

9562

Affinity Capture-MS

Homo sapiens

197

IGF2R

3482

Affinity Capture-MS

Homo sapiens

198

HSPG2

3339

Affinity Capture-MS

Homo sapiens

199

VASN

114990

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

200

ANKRD46

157567

Affinity Capture-MS

Homo sapiens

201

HS6ST2

90161

Affinity Capture-MS

Homo sapiens

202

LRIG1

26018

Affinity Capture-MS

Homo sapiens

203

POMT2

Affinity Capture-MS

Homo sapiens

204

COL6A1

1291

Affinity Capture-MS

Homo sapiens

205

PTPRG

5793

Affinity Capture-MS

Homo sapiens

206

SUCO

Affinity Capture-MS

Homo sapiens

207

CSTL1

Affinity Capture-MS

Homo sapiens

208

PAX4

Two-hybrid

Homo sapiens

209

C8A

731

Affinity Capture-MS

Homo sapiens

210

MAN2B1

4125

Affinity Capture-MS

Homo sapiens

211

AZU1

566

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

212

SORL1

6653

Affinity Capture-MS

Homo sapiens

213

SGSH

6448

Affinity Capture-MS

Homo sapiens

214

TMED4

222068

Affinity Capture-MS

Homo sapiens

215

GDF9

2661

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

216

IGHM

3507

Affinity Capture-MS

Homo sapiens

217

ROBO1

6091

Affinity Capture-MS

Homo sapiens

218

SYNE2

23224

Affinity Capture-MS

Homo sapiens

219

ERO1LB

56605

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

220

KAT7

Affinity Capture-MS

Homo sapiens

221

PLOD3

8985

Affinity Capture-MS

Homo sapiens

222

SERPINE2

5270

Affinity Capture-MS

Homo sapiens

223

AHSG

197

Reconstituted Complex		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens

224

DSC2

1824

Affinity Capture-MS

Homo sapiens

225

NUP210

23225

Affinity Capture-MS

Homo sapiens

226

ADGRG6

57211

Affinity Capture-MS

Homo sapiens

227

CD276

80381

Affinity Capture-MS

Homo sapiens

228

CTSZ

1522

Affinity Capture-MS

Homo sapiens

229

EPHA1

2041

Affinity Capture-MS

Homo sapiens

230

ENPP1

5167

Affinity Capture-MS

Homo sapiens

231

ITGA4

3676

Affinity Capture-MS

Homo sapiens

232

ST8SIA4

7903

Affinity Capture-MS

Homo sapiens

233

ALCAM

214

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

234

SULF1

23213

Affinity Capture-MS

Homo sapiens

235

NCSTN

23385

Affinity Capture-MS

Homo sapiens

236

CACNA2D2

9254

Affinity Capture-MS

Homo sapiens

237

SEZ6L2

26470

Affinity Capture-MS

Homo sapiens

238

SEMA6B

10501

Affinity Capture-MS

Homo sapiens

239

ITGA6

3655

Affinity Capture-MS

Homo sapiens

240

IGF1R

3480

Affinity Capture-MS

Homo sapiens

241

LAMC2

3918

Affinity Capture-MS

Homo sapiens

242

CSPG4

1464

Affinity Capture-MS

Homo sapiens

243

FLT1

2321

Affinity Capture-MS

Homo sapiens

244

BCHE

590

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

245

B3GALNT2

148789

Affinity Capture-MS

Homo sapiens

246

CDHR4

Affinity Capture-MS

Homo sapiens

247

UBE2D3

7323

Reconstituted Complex

Homo sapiens

248

PLXNA3

55558

Affinity Capture-MS

Homo sapiens

249

LIFR

3977

Affinity Capture-MS

Homo sapiens

250

CREG1

8804

Affinity Capture-MS

Homo sapiens

251

TXNDC11

51061

Affinity Capture-MS

Homo sapiens

252

SLC4A7

9497

Affinity Capture-MS

Homo sapiens

253

LAMC3

Affinity Capture-MS

Homo sapiens

254

CD320

51293

Affinity Capture-MS

Homo sapiens

255

GPAA1

8733

Affinity Capture-MS

Homo sapiens

256

EMC3

55831

Affinity Capture-MS

Homo sapiens

257

ATF6

Affinity Capture-MS

Homo sapiens

258

ADAMTS7

Affinity Capture-MS

Homo sapiens

259

B3GNT3

10331

Affinity Capture-MS

Homo sapiens

260

TENM3

55714

Affinity Capture-MS

Homo sapiens

261

CASC4

113201

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

262

LOXL2

4017

Affinity Capture-MS

Homo sapiens

263

CBLN4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

264

LAMA1

284217

Affinity Capture-MS

Homo sapiens

265

H6PD

9563

Affinity Capture-MS

Homo sapiens

266

ECE1

1889

Affinity Capture-MS

Homo sapiens

267

ADAM17

6868

Affinity Capture-MS

Homo sapiens

268

MGRN1

23295

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

269

HYOU1

10525

Affinity Capture-MS

Homo sapiens

270

KIAA0368

23392

Two-hybrid

Homo sapiens

271

POGLUT1

56983

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

272

VPS25

84313

Affinity Capture-MS

Homo sapiens

273

UBE2D1

7321

Reconstituted Complex

Homo sapiens

274

ADAM10

102

Affinity Capture-MS

Homo sapiens

275

LAMB1

3912

Affinity Capture-MS

Homo sapiens

276

TXNDC15

Affinity Capture-MS

Homo sapiens

277

PLXNA1

5361

Affinity Capture-MS

Homo sapiens

278

INSR

3643

Affinity Capture-MS

Homo sapiens

279

NPTXR

23467

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

280

LRP2

4036

Affinity Capture-MS

Homo sapiens

281

LIPA

3988

Affinity Capture-MS

Homo sapiens

282

LAMB3

3914

Affinity Capture-MS

Homo sapiens

283

ITGB5

3693

Affinity Capture-MS

Homo sapiens

284

JAG1

182

Affinity Capture-MS

Homo sapiens

285

GAS6

2621

Affinity Capture-MS

Homo sapiens

286

PVRL3

25945

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

287

NOTCH1

4851

Affinity Capture-MS

Homo sapiens

288

LRFN4

Affinity Capture-MS

Homo sapiens

289

KIAA0922

Affinity Capture-MS

Homo sapiens

290

NPTX2

Affinity Capture-MS

Homo sapiens

291

ST6GALNAC4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

292

TGFB1

7040

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

293

SLIT2

9353

Affinity Capture-MS

Homo sapiens

294

CACNA2D1

781

Affinity Capture-MS

Homo sapiens

295

FBN2

2201

Affinity Capture-MS

Homo sapiens

296

CELSR3

Affinity Capture-MS

Homo sapiens

297

POFUT1

23509

Affinity Capture-MS

Homo sapiens

298

WNT7A

Affinity Capture-MS

Homo sapiens

299

ERAP2

64167

Affinity Capture-MS

Homo sapiens

300

ARSB

411

Affinity Capture-MS

Homo sapiens

301

AGA

175

Affinity Capture-MS

Homo sapiens

302

VSTM1

Two-hybrid

Homo sapiens

303

LNPEP

4012

Affinity Capture-MS

Homo sapiens

304

THSD4

79875

Affinity Capture-MS

Homo sapiens

305

COL12A1

1303

Affinity Capture-MS

Homo sapiens

306

SULF2

55959

Affinity Capture-MS

Homo sapiens

307

BTN2A1

11120

Affinity Capture-MS

Homo sapiens

308

SEMA6A

Affinity Capture-MS

Homo sapiens

309

GLG1

2734

Affinity Capture-MS

Homo sapiens

310

INSL3

Affinity Capture-MS

Homo sapiens

311

CEMIP

57214

Affinity Capture-MS

Homo sapiens

312

CTBS

1486

Affinity Capture-MS

Homo sapiens

313

CPD

1362

Affinity Capture-MS

Homo sapiens

314

CD109

135228

Affinity Capture-MS

Homo sapiens

315

SERPINA5

5104

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

316

PRELP

5549

Affinity Capture-MS

Homo sapiens

317

SEMA4C

54910

Affinity Capture-MS

Homo sapiens

318

SEPN1

57190

Affinity Capture-MS

Homo sapiens

319

SNED1

Affinity Capture-MS

Homo sapiens

320

ITGA8

8516

Affinity Capture-MS

Homo sapiens

321

GUSB

2990

Affinity Capture-MS

Homo sapiens

322

SERPINA1

5265

Affinity Capture-Western

Homo sapiens

323

TMEM2

23670

Affinity Capture-MS

Homo sapiens

324

CHST12

55501

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

325

CADM4

199731

Affinity Capture-MS

Homo sapiens

326

ERVMER34-1

Affinity Capture-MS

Homo sapiens

327

MRC2

9902

Affinity Capture-MS

Homo sapiens

328

MERTK

10461

Affinity Capture-MS

Homo sapiens

329

ITGAV

3685

Affinity Capture-MS

Homo sapiens

330

LRIG2

Affinity Capture-MS

Homo sapiens

331

LINGO1

84894

Affinity Capture-MS

Homo sapiens

332

SCAP

Affinity Capture-MS

Homo sapiens

333

MANBA

4126

Affinity Capture-MS

Homo sapiens

334

VCP

7415

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

335

MIA3

375056

Affinity Capture-MS

Homo sapiens

336

TPBG

7162

Affinity Capture-MS

Homo sapiens

337

NELL2

Affinity Capture-MS

Homo sapiens

338

LMF2

91289

Affinity Capture-MS

Homo sapiens

339

SUMF1

285362

Affinity Capture-MS

Homo sapiens

340

OSMR

9180

Affinity Capture-MS

Homo sapiens

341

PLXNA2

5362

Affinity Capture-MS

Homo sapiens

342

COL14A1

7373

Affinity Capture-MS

Homo sapiens

343

MEGF8

1954

Affinity Capture-MS

Homo sapiens

344

CACHD1

Affinity Capture-MS

Homo sapiens

345

PLAT

5327

Affinity Capture-MS

Homo sapiens

346

CD101

9398

Affinity Capture-MS

Homo sapiens

347

CNTNAP1

8506

Affinity Capture-MS

Homo sapiens

348

NFS1

9054

Affinity Capture-MS

Homo sapiens

349

GAA

2548

Affinity Capture-MS

Homo sapiens

350

TMEM39A

Affinity Capture-MS

Homo sapiens

351

UBE2D2

7322

Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens

352

C1RL

51279

Affinity Capture-MS

Homo sapiens

353

PTPRJ

5795

Affinity Capture-MS

Homo sapiens

354

CNTNAP3B

Affinity Capture-MS

Homo sapiens

355

NTM

50863

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

356

LGMN

5641

Affinity Capture-MS

Homo sapiens

357

FGFR1

2260

Affinity Capture-MS

Homo sapiens

358

IGSF9

Affinity Capture-MS

Homo sapiens

359

SEMA4G

Affinity Capture-MS

Homo sapiens

360

RNASET2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

361

PTPRU

Affinity Capture-MS

Homo sapiens

362

KIAA0319L

79932

Affinity Capture-MS

Homo sapiens

363

BMP1

649

Affinity Capture-MS

Homo sapiens

364

BMP4

652

Affinity Capture-MS

Homo sapiens

365

GGCX

2677

Affinity Capture-MS

Homo sapiens

366

KRT16

3868

Affinity Capture-Western

Homo sapiens

367

DNAJC13

23317

Affinity Capture-MS

Homo sapiens

368

VPS36

51028

Affinity Capture-MS

Homo sapiens

369

SEL1L3

Affinity Capture-MS

Homo sapiens

370

ITGA5

3678

Affinity Capture-MS

Homo sapiens

371

COLEC12

81035

Affinity Capture-MS

Homo sapiens

372

TTC17

55761

Affinity Capture-MS

Homo sapiens

373

SIAE

54414

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

374

LAMA3

3909

Affinity Capture-MS

Homo sapiens

375

CTSV

1515

Affinity Capture-MS

Homo sapiens

376

BACE1

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens

377

PCDH9

Affinity Capture-MS

Homo sapiens

378

OSTM1

28962

Affinity Capture-MS

Homo sapiens

379

PIGK

10026

Affinity Capture-MS

Homo sapiens

380

COL18A1

80781

Affinity Capture-MS

Homo sapiens

381

COCH

1690

Affinity Capture-MS

Homo sapiens

382

COL6A2

1292

Affinity Capture-MS

Homo sapiens

383

ANAPC2

29882

Affinity Capture-Western

Homo sapiens

384

GZMH

Affinity Capture-MS

Homo sapiens

385

EPHA5

2044

Affinity Capture-MS

Homo sapiens

386

UBB

7314

Affinity Capture-MS

Homo sapiens

387

TAPBP

6892

Affinity Capture-MS

Homo sapiens

388

PTPRS

5802

Affinity Capture-MS

Homo sapiens

389

PTPRK

5796

Affinity Capture-MS

Homo sapiens

390

ARSK

Affinity Capture-MS

Homo sapiens

391

CILP2

Affinity Capture-MS

Homo sapiens

392

SEMA4B

Affinity Capture-MS

Homo sapiens

View the network

Pathways in which FBXO2 is involved

Pathway	Evidence	Source
Adaptive Immune System	TAS	Reactome
Antigen processing: Ubiquitination & Proteasome degradation	TAS	Reactome
Class I MHC mediated antigen processing & presentation	TAS	Reactome
Immune System	TAS	Reactome
Metabolism of proteins	TAS	Reactome
Neddylation	TAS	Reactome
Post-translational protein modification	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here