Gene description for GNPTAB
Gene name N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Gene symbol GNPTAB
Other names/aliases GNPTA
ICD
Species Homo sapiens
 Database cross references - GNPTAB
ExoCarta ExoCarta_79158
Vesiclepedia VP_79158
Entrez Gene 79158
HGNC 29670
MIM 607840
UniProt Q3T906  
 GNPTAB identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for GNPTAB
Molecular Function
    UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity GO:0003976 IBA
    UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity GO:0003976 IDA
    UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity GO:0003976 IMP
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    lysosome organization GO:0007040 IMP
    N-glycan processing to lysosome GO:0016256 IBA
    N-glycan processing to lysosome GO:0016256 IMP
    secretion of lysosomal enzymes GO:0033299 IEA
    carbohydrate phosphorylation GO:0046835 IDA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified GNPTAB in sEVs
1
Experiment ID 834
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for GNPTAB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAB 7529
Cross-Linking-MS (XL-MS) Homo sapiens
2 SPPL2B 56928
Affinity Capture-MS Homo sapiens
3 B3GALT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 Anapc2  
Affinity Capture-MS Mus musculus
5 PICK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 FASN 2194
Negative Genetic Homo sapiens
7 TMEM106A  
Affinity Capture-MS Homo sapiens
8 PDYN  
Affinity Capture-MS Homo sapiens
9 Cdc23  
Affinity Capture-MS Mus musculus
10 NDST4  
Affinity Capture-MS Homo sapiens
11 MAPK1 5594
Two-hybrid Homo sapiens
12 AEN  
Two-hybrid Homo sapiens
13 CHST8 64377
Affinity Capture-MS Homo sapiens
14 ANAPC15  
Affinity Capture-MS Homo sapiens
15 THOC2 57187
Affinity Capture-MS Homo sapiens
16 DISC1 27185
Two-hybrid Homo sapiens
17 LGALS1 3956
Affinity Capture-MS Homo sapiens
18 ZNF250  
Two-hybrid Homo sapiens
19 FAM3B 54097
Affinity Capture-MS Homo sapiens
20 FAM90A1  
Two-hybrid Homo sapiens
21 C5AR1  
Affinity Capture-MS Homo sapiens
22 SOX2  
Affinity Capture-MS Homo sapiens
23 APP 351
Reconstituted Complex Homo sapiens
24 PSMA1 5682
Two-hybrid Homo sapiens
25 Cdc16  
Affinity Capture-MS Mus musculus
26 PRR27 401137
Affinity Capture-MS Homo sapiens
27 FAM134C 162427
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 C22orf42  
Affinity Capture-MS Homo sapiens
29 IGSF6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 ATP6V1G1 9550
Cross-Linking-MS (XL-MS) Homo sapiens
31 FBXO2 26232
Affinity Capture-MS Homo sapiens
32 RPS7 6201
Cross-Linking-MS (XL-MS) Homo sapiens
33 S1PR4  
Affinity Capture-MS Homo sapiens
34 PXYLP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 OC90  
Affinity Capture-MS Homo sapiens
36 DSE 29940
Affinity Capture-MS Homo sapiens
37 GNPTG 84572
Affinity Capture-MS Homo sapiens
38 SGCZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 STAMBPL1  
Two-hybrid Homo sapiens
40 APC  
Cross-Linking-MS (XL-MS) Homo sapiens
41 RASSF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ZPLD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 Cdc26  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which GNPTAB is involved
No pathways found





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