Gene description for ERO1LB
Gene name ERO1-like beta (S. cerevisiae)
Gene symbol ERO1LB
Other names/aliases -
Species Homo sapiens
 Database cross references - ERO1LB
ExoCarta ExoCarta_56605
Vesiclepedia VP_56605
Entrez Gene 56605
HGNC 14355
MIM 615437
UniProt Q86YB8  
 ERO1LB identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ERO1LB
Molecular Function
    protein binding GO:0005515 IPI
    protein-disulfide reductase activity GO:0015035 EXP
    protein-disulfide reductase activity GO:0015035 IBA
    oxidoreductase activity GO:0016491 NAS
    thiol oxidase activity GO:0016972 IDA
    unfolded protein binding GO:0051082 NAS
    FAD binding GO:0071949 IEA
Biological Process
    protein folding GO:0006457 TAS
    insulin processing GO:0030070 TAS
    protein folding in endoplasmic reticulum GO:0034975 IBA
    protein folding in endoplasmic reticulum GO:0034975 IDA
Subcellular Localization
    endoplasmic reticulum GO:0005783 TAS
    endoplasmic reticulum lumen GO:0005788 TAS
    endoplasmic reticulum membrane GO:0005789 IBA
 Experiment description of studies that identified ERO1LB in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ERO1LB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYZL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 LY6H  
Affinity Capture-MS Homo sapiens
3 C7orf34  
Affinity Capture-MS Homo sapiens
4 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
5 CEACAM8 1088
Affinity Capture-MS Homo sapiens
6 PDIA2 64714
Affinity Capture-Western Homo sapiens
7 LRRC59 55379
Proximity Label-MS Homo sapiens
8 PSMA4 5685
Co-fractionation Homo sapiens
9 PDIA4 9601
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
10 CALU 813
Proximity Label-MS Homo sapiens
11 CALR3  
Proximity Label-MS Homo sapiens
12 CGA  
Affinity Capture-MS Homo sapiens
13 PDGFRA 5156
Affinity Capture-MS Homo sapiens
14 BRCA1 672
Two-hybrid Homo sapiens
15 GPX4 2879
Co-fractionation Homo sapiens
16 SKP1 6500
Affinity Capture-MS Homo sapiens
17 ERO1L 30001
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 PDIA3 2923
Affinity Capture-Western Homo sapiens
19 LYZL1  
Affinity Capture-MS Homo sapiens
20 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 SLURP1  
Affinity Capture-MS Homo sapiens
22 HEPACAM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ERP44 23071
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
24 HPN  
Affinity Capture-MS Homo sapiens
25 BRICD5  
Affinity Capture-MS Homo sapiens
26 ZNF641  
Affinity Capture-MS Homo sapiens
27 FBXO2 26232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 OGT 8473
Reconstituted Complex Homo sapiens
29 HSPA5 3309
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SCGB2A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 C1orf54  
Affinity Capture-MS Homo sapiens
32 PTPRK 5796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 P4HB 5034
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
34 ATP4A 495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 ST14 6768
Affinity Capture-MS Homo sapiens
36 RPA3 6119
Proximity Label-MS Homo sapiens
37 PVRL3 25945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SEC61B 10952
Proximity Label-MS Homo sapiens
39 TMPRSS13  
Affinity Capture-MS Homo sapiens
40 UST  
Affinity Capture-MS Homo sapiens
41 PLA2G10  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ERO1LB is involved
PathwayEvidenceSource
Insulin processing TAS Reactome
Metabolism of proteins TAS Reactome
Peptide hormone metabolism TAS Reactome





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