Gene description for ADAM23
Gene name ADAM metallopeptidase domain 23
Gene symbol ADAM23
Other names/aliases MDC-3
MDC3
Species Homo sapiens
 Database cross references - ADAM23
ExoCarta ExoCarta_8745
Vesiclepedia VP_8745
Entrez Gene 8745
HGNC 202
MIM 603710
UniProt O75077  
 ADAM23 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ADAM23
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    integrin binding GO:0005178 TAS
    protein binding GO:0005515 IPI
    metallopeptidase activity GO:0008237 TAS
Biological Process
    proteolysis GO:0006508 IBA
    cell adhesion GO:0007155 IEA
    central nervous system development GO:0007417 TAS
    cellular response to leukemia inhibitory factor GO:1990830 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 TAS
    presynaptic membrane GO:0042734 IBA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified ADAM23 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ADAM23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CANX 821
Affinity Capture-MS Homo sapiens
2 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
3 ADAM11 4185
Affinity Capture-MS Homo sapiens
4 FBXO2 26232
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ADAM23 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
LGI-ADAM interactions TAS Reactome





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