Gene description for OSMR
Gene name oncostatin M receptor
Gene symbol OSMR
Other names/aliases OSMRB
PLCA1
Species Homo sapiens
 Database cross references - OSMR
ExoCarta ExoCarta_9180
Vesiclepedia VP_9180
Entrez Gene 9180
HGNC 8507
MIM 601743
UniProt Q99650  
 OSMR identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Endothelial cells 26027894    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for OSMR
Molecular Function
    cytokine receptor activity GO:0004896 IBA
    oncostatin-M receptor activity GO:0004924 IBA
    oncostatin-M receptor activity GO:0004924 IDA
    ciliary neurotrophic factor receptor binding GO:0005127 IBA
    protein binding GO:0005515 IPI
    growth factor binding GO:0019838 IPI
    cytokine binding GO:0019955 IBA
Biological Process
    positive regulation of acute inflammatory response GO:0002675 IC
    positive regulation of cell population proliferation GO:0008284 IBA
    positive regulation of cell population proliferation GO:0008284 IGI
    cytokine-mediated signaling pathway GO:0019221 IBA
    response to cytokine GO:0034097 IDA
    oncostatin-M-mediated signaling pathway GO:0038165 IMP
Subcellular Localization
    plasma membrane GO:0005886 TAS
    oncostatin-M receptor complex GO:0005900 IDA
    external side of plasma membrane GO:0009897 IBA
    apical plasma membrane GO:0016324 IDA
    receptor complex GO:0043235 IBA
 Experiment description of studies that identified OSMR in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
6
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
7
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for OSMR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BAG3 9531
Affinity Capture-MS Homo sapiens
2 PCDHA8  
Affinity Capture-MS Homo sapiens
3 RELT  
Affinity Capture-MS Homo sapiens
4 SGTB  
Two-hybrid Homo sapiens
5 ANKLE2 23141
Affinity Capture-MS Homo sapiens
6 ERBB2 2064
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
7 SMARCA2 6595
Affinity Capture-MS Homo sapiens
8 TGFBR2 7048
Affinity Capture-MS Homo sapiens
9 KCNE3  
Affinity Capture-MS Homo sapiens
10 KCNC3 3748
Affinity Capture-MS Homo sapiens
11 SRPRB 58477
Affinity Capture-MS Homo sapiens
12 IL20RB  
Affinity Capture-MS Homo sapiens
13 LHX2  
Two-hybrid Homo sapiens
14 UBQLN2 29978
Two-hybrid Homo sapiens
15 Bmpr1a  
Affinity Capture-MS Mus musculus
16 MANSC1 54682
Affinity Capture-MS Homo sapiens
17 CUL5 8065
Affinity Capture-MS Homo sapiens
18 KCNJ15  
Affinity Capture-MS Homo sapiens
19 TMEM204  
Affinity Capture-MS Homo sapiens
20 EGFR 1956
Affinity Capture-Western Homo sapiens
21 DLK1  
Affinity Capture-MS Homo sapiens
22 ZDHHC19  
Affinity Capture-MS Homo sapiens
23 GPRC5D  
Two-hybrid Homo sapiens
24 FFAR1  
Affinity Capture-MS Homo sapiens
25 TMEM150A  
Affinity Capture-MS Homo sapiens
26 TMEM200A 114801
Affinity Capture-MS Homo sapiens
27 VSIG4  
Affinity Capture-MS Homo sapiens
28 RELL2  
Affinity Capture-MS Homo sapiens
29 IL6ST 3572
Affinity Capture-Western Homo sapiens
30 GAPDH 2597
Two-hybrid Homo sapiens
31 OSM 5008
Reconstituted Complex Homo sapiens
32 BTN2A1 11120
Affinity Capture-MS Homo sapiens
33 JAK1 3716
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 FBXO2 26232
Affinity Capture-MS Homo sapiens
35 ZFYVE21  
Affinity Capture-MS Homo sapiens
36 TMEM231 79583
Affinity Capture-MS Homo sapiens
37 TREML2 79865
Affinity Capture-MS Homo sapiens
38 SLC10A6  
Two-hybrid Homo sapiens
39 RNF133  
Affinity Capture-MS Homo sapiens
40 GPRC5B 51704
Affinity Capture-MS Homo sapiens
41 SLC31A1 1317
Affinity Capture-MS Homo sapiens
42 PIGH  
Affinity Capture-MS Homo sapiens
43 MRAP2  
Affinity Capture-MS Homo sapiens
44 KCNE4  
Affinity Capture-MS Homo sapiens
45 PCDHB3  
Affinity Capture-MS Homo sapiens
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