Gene description for OSM
Gene name oncostatin M
Gene symbol OSM
Other names/aliases -
Species Homo sapiens
 Database cross references - OSM
ExoCarta ExoCarta_5008
Vesiclepedia VP_5008
Entrez Gene 5008
HGNC 8506
MIM 165095
UniProt P13725  
 OSM identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for OSM
Molecular Function
    cytokine activity GO:0005125 IBA
    cytokine activity GO:0005125 IDA
    oncostatin-M receptor binding GO:0005147 IPI
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IDA
Biological Process
    positive regulation of acute inflammatory response GO:0002675 IC
    immune response GO:0006955 IEA
    positive regulation of cell population proliferation GO:0008284 IDA
    negative regulation of cell population proliferation GO:0008285 TAS
    positive regulation of interleukin-17 production GO:0032740 IDA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA
    oncostatin-M-mediated signaling pathway GO:0038165 IDA
    positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 IDA
    positive regulation of MAPK cascade GO:0043410 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    negative regulation of hormone secretion GO:0046888 IDA
    positive regulation of inflammatory response GO:0050729 IDA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    positive regulation of cell division GO:0051781 IEA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IGI
    regulation of hematopoietic stem cell differentiation GO:1902036 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified OSM in sEVs
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for OSM
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 C1QBP 708
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 COL4A6 1288
Co-localization Homo sapiens
4 OSMR 9180
Reconstituted Complex Homo sapiens
5 IL6ST 3572
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 C5orf22  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ZNF579  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TRPM3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TNNT1  
Two-hybrid Homo sapiens
10 LIFR 3977
Affinity Capture-Western Homo sapiens
11 UBE2O 63893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 BRWD3  
Affinity Capture-MS Homo sapiens
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