Gene description for SULF1
Gene name sulfatase 1
Gene symbol SULF1
Other names/aliases HSULF-1
SULF-1
Species Homo sapiens
 Database cross references - SULF1
ExoCarta ExoCarta_23213
Vesiclepedia VP_23213
Entrez Gene 23213
HGNC 20391
MIM 610012
UniProt Q8IWU6  
 SULF1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SULF1
Molecular Function
    arylsulfatase activity GO:0004065 IDA
    arylsulfatase activity GO:0004065 IMP
    calcium ion binding GO:0005509 IEA
    glycosaminoglycan binding GO:0005539 IBA
    N-acetylglucosamine-6-sulfatase activity GO:0008449 IBA
    N-acetylglucosamine-6-sulfatase activity GO:0008449 IDA
    N-acetylglucosamine-6-sulfatase activity GO:0008449 IMP
Biological Process
    kidney development GO:0001822 ISS
    negative regulation of endothelial cell proliferation GO:0001937 IDA
    chondrocyte development GO:0002063 ISS
    glomerular filtration GO:0003094 ISS
    apoptotic process GO:0006915 IEA
    positive regulation of vascular endothelial growth factor production GO:0010575 IBA
    positive regulation of vascular endothelial growth factor production GO:0010575 ISS
    esophagus smooth muscle contraction GO:0014846 ISS
    negative regulation of angiogenesis GO:0016525 IDA
    positive regulation of Wnt signaling pathway GO:0030177 IBA
    positive regulation of Wnt signaling pathway GO:0030177 IDA
    heparan sulfate proteoglycan metabolic process GO:0030201 IBA
    heparan sulfate proteoglycan metabolic process GO:0030201 IDA
    heparan sulfate proteoglycan metabolic process GO:0030201 NAS
    negative regulation of cell migration GO:0030336 IMP
    positive regulation of BMP signaling pathway GO:0030513 IMP
    glomerular basement membrane development GO:0032836 IBA
    glomerular basement membrane development GO:0032836 ISS
    glial cell-derived neurotrophic factor receptor signaling pathway GO:0035860 ISS
    regulation of fibroblast growth factor receptor signaling pathway GO:0040036 IMP
    negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 IBA
    negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 IMP
    negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 ISS
    vascular endothelial growth factor receptor signaling pathway GO:0048010 IDA
    embryonic skeletal system development GO:0048706 ISS
    cartilage development GO:0051216 ISS
    bone development GO:0060348 ISS
    innervation GO:0060384 ISS
    negative regulation of prostatic bud formation GO:0060686 ISS
Subcellular Localization
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 NAS
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 IDA
    Golgi apparatus GO:0005794 ISS
    Golgi stack GO:0005795 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    membrane raft GO:0045121 IDA
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified SULF1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SULF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
2 CCL3  
Affinity Capture-MS Homo sapiens
3 LY6H  
Affinity Capture-MS Homo sapiens
4 C7orf34  
Affinity Capture-MS Homo sapiens
5 LYZL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 GPIHBP1  
Affinity Capture-MS Homo sapiens
7 SYCN  
Affinity Capture-MS Homo sapiens
8 NEDD4 4734
Reconstituted Complex Homo sapiens
9 RETNLB  
Affinity Capture-MS Homo sapiens
10 NOTCH2 4853
Affinity Capture-MS Homo sapiens
11 C1orf54  
Affinity Capture-MS Homo sapiens
12 HPN  
Affinity Capture-MS Homo sapiens
13 PDGFRA 5156
Affinity Capture-MS Homo sapiens
14 PMCH  
Affinity Capture-MS Homo sapiens
15 LRRC4C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 OS9 10956
Affinity Capture-MS Homo sapiens
17 INSL5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SDC2 6383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 INS 3630
Affinity Capture-MS Homo sapiens
20 MFAP5  
Affinity Capture-MS Homo sapiens
21 SULF2 55959
Affinity Capture-MS Homo sapiens
22 FBXO2 26232
Affinity Capture-MS Homo sapiens
23 SCGB2A2  
Affinity Capture-MS Homo sapiens
24 ZCCHC10  
Affinity Capture-MS Homo sapiens
25 PSCA 8000
Affinity Capture-MS Homo sapiens
26 BAGE2  
Affinity Capture-MS Homo sapiens
27 ST14 6768
Affinity Capture-MS Homo sapiens
28 NOG 9241
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SULF1 is involved
No pathways found





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