Gene description for HSD11B1
Gene name hydroxysteroid (11-beta) dehydrogenase 1
Gene symbol HSD11B1
Other names/aliases 11-DH
11-beta-HSD1
CORTRD2
HDL
HSD11
HSD11B
HSD11L
SDR26C1
Species Homo sapiens
 Database cross references - HSD11B1
ExoCarta ExoCarta_3290
Vesiclepedia VP_3290
Entrez Gene 3290
HGNC 5208
MIM 600713
UniProt P28845  
 HSD11B1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for HSD11B1
Molecular Function
    steroid binding GO:0005496 IBA
    protein homodimerization activity GO:0042803 IDA
    7-beta-hydroxysteroid dehydrogenase (NADP+) activity GO:0047022 IEA
    NADP binding GO:0050661 IDA
    11-beta-hydroxysteroid dehydrogenase (NADP+) activity GO:0070524 IBA
    11-beta-hydroxysteroid dehydrogenase (NADP+) activity GO:0070524 IDA
    cortisol dehydrogenase activity GO:0102196 IEA
Biological Process
    steroid catabolic process GO:0006706 IBA
    lung development GO:0030324 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 HDA
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified HSD11B1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HSD11B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BRD1 23774
Affinity Capture-MS Homo sapiens
2 GKAP1  
Two-hybrid Homo sapiens
3 CD36 948
Reconstituted Complex Homo sapiens
4 RAB18 22931
Affinity Capture-MS Homo sapiens
5 OS9 10956
Affinity Capture-MS Homo sapiens
6 TMX4 56255
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 MANEA 79694
Affinity Capture-MS Homo sapiens
8 DAD1 1603
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SURF1  
Affinity Capture-MS Homo sapiens
10 CDC42SE2 56990
Affinity Capture-MS Homo sapiens
11 TMBIM6 7009
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 INSR 3643
Affinity Capture-MS Homo sapiens
13 EGFR 1956
Affinity Capture-MS Homo sapiens
14 GLB1L2  
Affinity Capture-MS Homo sapiens
15 ACSL4 2182
Affinity Capture-MS Homo sapiens
16 TOR1A 1861
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 FAM69A 388650
Affinity Capture-MS Homo sapiens
18 NPTX1  
Affinity Capture-MS Homo sapiens
19 TMX2 51075
Affinity Capture-MS Homo sapiens
20 NHLRC3 387921
Affinity Capture-MS Homo sapiens
21 UGT8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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