Gene description for DNAH6
Gene name dynein, axonemal, heavy chain 6
Gene symbol DNAH6
Other names/aliases DNHL1
Dnahc6
HL-2
HL2
Species Homo sapiens
 Database cross references - DNAH6
ExoCarta ExoCarta_1768
Vesiclepedia VP_1768
Entrez Gene 1768
HGNC 2951
MIM 603336
UniProt Q9C0G6  
 DNAH6 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DNAH6
Molecular Function
    ATP binding GO:0005524 IEA
    minus-end-directed microtubule motor activity GO:0008569 IBA
    ATP hydrolysis activity GO:0016887 IEA
    dynein intermediate chain binding GO:0045505 IBA
    dynein light intermediate chain binding GO:0051959 IBA
Biological Process
    cilium movement involved in cell motility GO:0060294 IBA
Subcellular Localization
    microtubule GO:0005874 IEA
    axoneme GO:0005930 IEA
    dynein complex GO:0030286 IBA
    9+2 motile cilium GO:0097729 IBA
 Experiment description of studies that identified DNAH6 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DNAH6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSN 2934
Cross-Linking-MS (XL-MS) Homo sapiens
2 RALBP1 10928
Cross-Linking-MS (XL-MS) Homo sapiens
3 NUMA1 4926
Cross-Linking-MS (XL-MS) Homo sapiens
4 GAN 8139
Affinity Capture-MS Homo sapiens
5 BUD31 8896
Cross-Linking-MS (XL-MS) Homo sapiens
6 NAA20  
Cross-Linking-MS (XL-MS) Homo sapiens
7 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
8 HNRNPA0 10949
Cross-Linking-MS (XL-MS) Homo sapiens
9 SHFM1 7979
Affinity Capture-MS Homo sapiens
10 EPX 8288
Cross-Linking-MS (XL-MS) Homo sapiens
11 HNRNPA1 3178
Cross-Linking-MS (XL-MS) Homo sapiens
12 PSIP1 11168
Cross-Linking-MS (XL-MS) Homo sapiens
13 MYH9 4627
Cross-Linking-MS (XL-MS) Homo sapiens
14 H1FX 8971
Cross-Linking-MS (XL-MS) Homo sapiens
15 HNRNPA1L2 144983
Cross-Linking-MS (XL-MS) Homo sapiens
16 PI4KB 5298
Cross-Linking-MS (XL-MS) Homo sapiens
17 SLC26A11 284129
Affinity Capture-MS Homo sapiens
18 FAIM3  
Cross-Linking-MS (XL-MS) Homo sapiens
19 HNRNPA3 220988
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
20 MRPL2 51069
Cross-Linking-MS (XL-MS) Homo sapiens
21 HNRNPA2B1 3181
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
22 H2AFX 3014
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which DNAH6 is involved
No pathways found





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