Gene description for EPX
Gene name eosinophil peroxidase
Gene symbol EPX
Other names/aliases EPO
EPP
EPX-PEN
Species Homo sapiens
 Database cross references - EPX
ExoCarta ExoCarta_8288
Vesiclepedia VP_8288
Entrez Gene 8288
HGNC 3423
MIM 131399
UniProt P11678  
 EPX identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for EPX
Molecular Function
    peroxidase activity GO:0004601 IBA
    heme binding GO:0020037 IEA
    metal ion binding GO:0046872 IEA
    lactoperoxidase activity GO:0140825 IEA
Biological Process
    defense response to nematode GO:0002215 IEA
    response to oxidative stress GO:0006979 IEA
    negative regulation of macrophage cytokine production GO:0010936 IEA
    negative regulation of interleukin-10 production GO:0032693 IEA
    negative regulation of interleukin-5 production GO:0032714 IEA
    positive regulation of interleukin-4 production GO:0032753 IEA
    defense response to bacterium GO:0042742 IBA
    hydrogen peroxide catabolic process GO:0042744 IEA
    eosinophil migration GO:0072677 IEA
    cellular oxidant detoxification GO:0098869 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    secretory granule lumen GO:0034774 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified EPX in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EPX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAH6 1768
Cross-Linking-MS (XL-MS) Homo sapiens
2 GAN 8139
Affinity Capture-MS Homo sapiens
3 OR13C3  
Affinity Capture-MS Homo sapiens
4 TTC19  
Affinity Capture-MS Homo sapiens
5 HNRNPA2B1 3181
Cross-Linking-MS (XL-MS) Homo sapiens
6 DNAH2 146754
Cross-Linking-MS (XL-MS) Homo sapiens
7 TMEM237 65062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 HNRNPA3 220988
Cross-Linking-MS (XL-MS) Homo sapiens
9 STX17 55014
Affinity Capture-MS Homo sapiens
10 HNRNPA1 3178
Cross-Linking-MS (XL-MS) Homo sapiens
11 RAB11A 8766
Affinity Capture-MS Homo sapiens
12 TMEM74  
Affinity Capture-MS Homo sapiens
13 HNRNPA1L2 144983
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which EPX is involved
PathwayEvidenceSource
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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