Gene description for KLHDC8B
Gene name kelch domain containing 8B
Gene symbol KLHDC8B
Other names/aliases CHL
Species Homo sapiens
 Database cross references - KLHDC8B
ExoCarta ExoCarta_200942
Vesiclepedia VP_200942
Entrez Gene 200942
HGNC 28557
MIM 613169
UniProt Q8IXV7  
 KLHDC8B identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for KLHDC8B
Biological Process
    nuclear chromosome segregation GO:0098813 IBA
    nuclear chromosome segregation GO:0098813 IMP
    mitotic nuclear division GO:0140014 IBA
    mitotic nuclear division GO:0140014 IMP
    mitotic cytokinetic process GO:1902410 IBA
    mitotic cytokinetic process GO:1902410 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    midbody GO:0030496 IBA
    midbody GO:0030496 IDA
    intercellular bridge GO:0045171 IBA
    intercellular bridge GO:0045171 IDA
    cellularization cleavage furrow GO:0110070 IBA
    cellularization cleavage furrow GO:0110070 IDA
 Experiment description of studies that identified KLHDC8B in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for KLHDC8B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CCT5 22948
Affinity Capture-MS Homo sapiens
3 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PDCL3 79031
Affinity Capture-MS Homo sapiens
5 NANOS1 340719
Affinity Capture-MS Homo sapiens
6 SHOX  
Affinity Capture-MS Homo sapiens
7 IMPDH1 3614
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CCT2 10576
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KLHDC8B is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here