Gene description for Sla
Gene name src-like adaptor
Gene symbol Sla
Other names/aliases Slap
Slap-1
Species Mus musculus
 Database cross references - Sla
ExoCarta ExoCarta_20491
Vesiclepedia VP_20491
Entrez Gene 20491
UniProt Q60898  
 Sla identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Sla
Molecular Function
    phosphotyrosine residue binding GO:0001784 IBA
    epidermal growth factor receptor binding GO:0005154 IBA
    protein binding GO:0005515 IPI
Biological Process
    signal transduction GO:0007165 IBA
    regulation of MAPK cascade GO:0043408 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IBA
    cytoplasm GO:0005737 IBA
    endosome GO:0005768 IEA
    plasma membrane GO:0005886 IBA
    COP9 signalosome GO:0008180 IBA
 Experiment description of studies that identified Sla in sEVs
1
Experiment ID 907
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Sla
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Cd79a  
Affinity Capture-Western Mus musculus
2 Zap70 22637
Affinity Capture-Western Mus musculus
3 Cbl 12402
Affinity Capture-Western Mus musculus
4 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Sla is involved
PathwayEvidenceSource
Cytokine Signaling in Immune system IEA Reactome
FLT3 Signaling IEA Reactome
Immune System IEA Reactome
Negative regulation of FLT3 IEA Reactome





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