Gene description for Ahsa1
Gene name AHA1, activator of heat shock protein ATPase 1
Gene symbol Ahsa1
Other names/aliases BC023857
p38
Species Mus musculus
 Database cross references - Ahsa1
ExoCarta ExoCarta_217737
Vesiclepedia VP_217737
Entrez Gene 217737
UniProt Q8BK64  
 Ahsa1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ahsa1
Molecular Function
    ATPase activator activity GO:0001671 IBA
    ATPase activator activity GO:0001671 ISO
    ATPase activator activity GO:0001671 ISS
    protein binding GO:0005515 IPI
    protein-folding chaperone binding GO:0051087 ISO
    Hsp90 protein binding GO:0051879 IPI
    Hsp90 protein binding GO:0051879 ISO
Biological Process
    protein folding GO:0006457 IBA
    protein folding GO:0006457 ISS
    positive regulation of ATP-dependent activity GO:0032781 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISS
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Ahsa1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ahsa1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tomm34 67145
Co-fractionation Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Atxn1  
Proximity Label-MS Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Stip1 20867
Co-fractionation Mus musculus
6 Mapt  
Affinity Capture-MS Mus musculus
7 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Ahsa1 is involved
No pathways found





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