Gene description for Larp4b
Gene name La ribonucleoprotein domain family, member 4B
Gene symbol Larp4b
Other names/aliases A630096F19
AI256361
D13Wsu64e
Larp5
Species Mus musculus
 Database cross references - Larp4b
ExoCarta ExoCarta_217980
Vesiclepedia VP_217980
Entrez Gene 217980
UniProt Q6A0A2  
 Larp4b identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Larp4b
Molecular Function
    molecular_function GO:0003674 ND
    mRNA 3'-UTR binding GO:0003730 IBA
    mRNA 3'-UTR binding GO:0003730 IEA
    mRNA 3'-UTR binding GO:0003730 ISO
Biological Process
    biological_process GO:0008150 ND
    positive regulation of translation GO:0045727 IBA
    positive regulation of translation GO:0045727 ISO
    positive regulation of translation GO:0045727 ISS
    positive regulation of 3'-UTR-mediated mRNA stabilization GO:1905870 IEA
    positive regulation of 3'-UTR-mediated mRNA stabilization GO:1905870 ISO
Subcellular Localization
    cellular_component GO:0005575 ND
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    cytoplasmic stress granule GO:0010494 IBA
    cytoplasmic stress granule GO:0010494 ISO
    cytoplasmic stress granule GO:0010494 ISS
 Experiment description of studies that identified Larp4b in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Larp4b
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atxn1  
Affinity Capture-MS Mus musculus
2 MKRN1 23608
Affinity Capture-MS Homo sapiens
3 Lmna 16905
Affinity Capture-MS Mus musculus
4 Fzr1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Larp4b is involved
No pathways found





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