Gene description for JMJD1C
Gene name jumonji domain containing 1C
Gene symbol JMJD1C
Other names/aliases TRIP8
Species Homo sapiens
 Database cross references - JMJD1C
ExoCarta ExoCarta_221037
Vesiclepedia VP_221037
Entrez Gene 221037
HGNC 12313
MIM 604503
UniProt Q15652  
 JMJD1C identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for JMJD1C
Molecular Function
    transcription coregulator activity GO:0003712 IBA
    protein binding GO:0005515 IPI
    chromatin DNA binding GO:0031490 IBA
    histone H3K9 demethylase activity GO:0032454 IBA
    histone H3K9 demethylase activity GO:0032454 TAS
    metal ion binding GO:0046872 IEA
    nuclear thyroid hormone receptor binding GO:0046966 TAS
    dioxygenase activity GO:0051213 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of DNA-templated transcription GO:0006355 TAS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    blood coagulation GO:0007596 TAS
Subcellular Localization
    histone deacetylase complex GO:0000118 IBA
    chromatin GO:0000785 IBA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified JMJD1C in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for JMJD1C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SOX7  
Proximity Label-MS Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
3 RNF43  
Proximity Label-MS Homo sapiens
4 NUDT21 11051
Two-hybrid Homo sapiens
5 ESR2  
FRET Homo sapiens
6 CBX1 10951
Affinity Capture-MS Homo sapiens
7 NUP43 348995
Proximity Label-MS Homo sapiens
8 NKX2-5  
Affinity Capture-MS Homo sapiens
9 RBPJ 3516
Affinity Capture-MS Homo sapiens
10 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
11 EGLN3  
Affinity Capture-MS Homo sapiens
12 PPARG 5468
FRET Homo sapiens
Protein-peptide Homo sapiens
13 H2AFZ 3015
Affinity Capture-MS Homo sapiens
14 PHLPP1  
Proximity Label-MS Homo sapiens
15 MEN1 4221
Affinity Capture-MS Homo sapiens
16 KLF3  
Proximity Label-MS Homo sapiens
17 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
18 NR3C1 2908
Proximity Label-MS Homo sapiens
19 VHL  
Affinity Capture-MS Homo sapiens
20 QPRT 23475
Affinity Capture-MS Homo sapiens
21 NUP35 129401
Proximity Label-MS Homo sapiens
22 TK1 7083
Two-hybrid Homo sapiens
23 PSMC1 5700
Two-hybrid Homo sapiens
24 MT2A 4502
Two-hybrid Homo sapiens
25 H1F0 3005
Affinity Capture-MS Homo sapiens
26 TRIM37  
Proximity Label-MS Homo sapiens
27 GADD45A  
Two-hybrid Homo sapiens
28 ALYREF 10189
Cross-Linking-MS (XL-MS) Homo sapiens
29 RPA3 6119
Proximity Label-MS Homo sapiens
30 RNF168  
Reconstituted Complex Homo sapiens
31 RNF8  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
32 DTX2 113878
Proximity Label-MS Homo sapiens
33 Thrb  
Two-hybrid Rattus norvegicus
34 PRDX2 7001
Cross-Linking-MS (XL-MS) Homo sapiens
35 FBXO38 81545
Proximity Label-MS Homo sapiens
36 CEBPA  
Proximity Label-MS Homo sapiens
37 AR 367
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
38 BCOR  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which JMJD1C is involved
PathwayEvidenceSource
Factors involved in megakaryocyte development and platelet production TAS Reactome
Hemostasis TAS Reactome





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