Gene description for OARD1
Gene name O-acyl-ADP-ribose deacylase 1
Gene symbol OARD1
Other names/aliases C6orf130
TARG1
dJ34B21.3
Species Homo sapiens
 Database cross references - OARD1
ExoCarta ExoCarta_221443
Vesiclepedia VP_221443
Entrez Gene 221443
HGNC 21257
MIM 614393
UniProt Q9Y530  
 OARD1 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for OARD1
Molecular Function
    purine nucleoside binding GO:0001883 IDA
    protein binding GO:0005515 IPI
    ADP-ribosyl-[dinitrogen reductase] hydrolase activity GO:0047407 IBA
    O-acetyl-ADP-ribose deacetylase activity GO:0061463 IDA
    ADP-ribosylglutamate hydrolase activity GO:0140293 IDA
Biological Process
    DNA damage response GO:0006974 IBA
    DNA damage response GO:0006974 IMP
    purine nucleoside metabolic process GO:0042278 IBA
    purine nucleoside metabolic process GO:0042278 IDA
    protein de-ADP-ribosylation GO:0051725 IDA
    peptidyl-glutamate ADP-deribosylation GO:0140291 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    site of DNA damage GO:0090734 IDA
 Experiment description of studies that identified OARD1 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for OARD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAH 7533
Affinity Capture-MS Homo sapiens
2 APP 351
Reconstituted Complex Homo sapiens
3 Gpsm1  
Affinity Capture-MS Mus musculus
4 Sgol1  
Affinity Capture-MS Mus musculus
5 TNKS 8658
Two-hybrid Homo sapiens
6 OXSR1 9943
Co-fractionation Homo sapiens
7 MYH9 4627
Affinity Capture-MS Homo sapiens
8 EEF1D 1936
Co-fractionation Homo sapiens
9 PSMD10 5716
Co-fractionation Homo sapiens
10 TIMM13 26517
Affinity Capture-MS Homo sapiens
11 Slain1  
Affinity Capture-MS Mus musculus
12 DDX58 23586
Affinity Capture-RNA Homo sapiens
View the network image/svg+xml
 Pathways in which OARD1 is involved
No pathways found





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