Gene description for TIMM13
Gene name translocase of inner mitochondrial membrane 13 homolog (yeast)
Gene symbol TIMM13
Other names/aliases TIM13
TIM13B
TIMM13A
TIMM13B
ppv1
Species Homo sapiens
 Database cross references - TIMM13
ExoCarta ExoCarta_26517
Vesiclepedia VP_26517
Entrez Gene 26517
HGNC 11816
MIM 607383
UniProt Q9Y5L4  
 TIMM13 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TIMM13
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 TAS
Biological Process
    protein targeting to mitochondrion GO:0006626 TAS
    sensory perception of sound GO:0007605 TAS
    protein insertion into mitochondrial inner membrane GO:0045039 IBA
    protein insertion into mitochondrial inner membrane GO:0045039 IMP
    protein insertion into mitochondrial inner membrane GO:0045039 NAS
    protein insertion into mitochondrial inner membrane GO:0045039 TAS
Subcellular Localization
    fibrillar center GO:0001650 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial intermembrane space GO:0005758 NAS
    mitochondrial intermembrane space protein transporter complex GO:0042719 IBA
    mitochondrial intermembrane space protein transporter complex GO:0042719 IPI
    mitochondrial intermembrane space protein transporter complex GO:0042719 ISS
    mitochondrial intermembrane space protein transporter complex GO:0042719 TAS
 Experiment description of studies that identified TIMM13 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TIMM13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 BPHL 670
Co-fractionation Homo sapiens
4 RASSF8 11228
Affinity Capture-MS Homo sapiens
5 ETV6  
Proximity Label-MS Homo sapiens
6 PDYN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 PSMD6 9861
Affinity Capture-MS Homo sapiens
8 PTBP1 5725
Co-fractionation Homo sapiens
9 LLGL1 3996
Affinity Capture-MS Homo sapiens
10 VPRBP 9730
Affinity Capture-MS Homo sapiens
11 ALB 213
Affinity Capture-MS Homo sapiens
12 DBN1 1627
Affinity Capture-MS Homo sapiens
13 CAND1 55832
Affinity Capture-MS Homo sapiens
14 CAB39 51719
Affinity Capture-MS Homo sapiens
15 PTRH1  
Affinity Capture-MS Homo sapiens
16 ILF2 3608
Co-fractionation Homo sapiens
17 CAPZB 832
Affinity Capture-MS Homo sapiens
18 RNPS1 10921
Affinity Capture-MS Homo sapiens
19 TIMM8A 1678
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
20 NDRG1 10397
Co-fractionation Homo sapiens
21 MATR3 9782
Affinity Capture-MS Homo sapiens
22 SF3B1 23451
Co-fractionation Homo sapiens
23 RPL24 6152
Co-fractionation Homo sapiens
24 SURF1  
Proximity Label-MS Homo sapiens
25 RAD51  
Affinity Capture-MS Homo sapiens
26 Kif3c  
Affinity Capture-MS Mus musculus
27 AIFM1 9131
Proximity Label-MS Homo sapiens
28 DDX6 1656
Co-fractionation Homo sapiens
29 SPATA5L1 79029
Affinity Capture-MS Homo sapiens
30 CUL1 8454
Affinity Capture-MS Homo sapiens
31 TIMM50 92609
Co-fractionation Homo sapiens
32 SOD1 6647
Affinity Capture-MS Homo sapiens
33 MDH2 4191
Co-fractionation Homo sapiens
34 KLF16  
Affinity Capture-MS Homo sapiens
35 APOO 79135
Proximity Label-MS Homo sapiens
36 AURKA 6790
Affinity Capture-MS Homo sapiens
37 ZNF385C  
Affinity Capture-MS Homo sapiens
38 DLD 1738
Affinity Capture-MS Homo sapiens
39 VILL  
Affinity Capture-MS Homo sapiens
40 FOXA1  
Affinity Capture-MS Homo sapiens
41 PRDM1  
Proximity Label-MS Homo sapiens
42 Arhgap6  
Affinity Capture-MS Mus musculus
43 COX15 1355
Proximity Label-MS Homo sapiens
44 MOB4 25843
Affinity Capture-MS Homo sapiens
45 PALMD  
Affinity Capture-MS Homo sapiens
46 LYZL6  
Affinity Capture-MS Homo sapiens
47 DIABLO 56616
Proximity Label-MS Homo sapiens
48 ALDH18A1 5832
Co-fractionation Homo sapiens
49 TIMM9  
Co-fractionation Homo sapiens
50 BCL7C  
Affinity Capture-MS Homo sapiens
51 WIPI2 26100
Co-fractionation Homo sapiens
52 OPA1 4976
Proximity Label-MS Homo sapiens
53 DICER1  
Affinity Capture-MS Homo sapiens
54 MRPL3  
Affinity Capture-MS Homo sapiens
55 ANAPC4 29945
Affinity Capture-MS Homo sapiens
56 CUL2 8453
Affinity Capture-MS Homo sapiens
57 DNM1L 10059
Affinity Capture-MS Homo sapiens
58 CDT1  
Affinity Capture-MS Homo sapiens
59 COX4I1 1327
Proximity Label-MS Homo sapiens
60 HSPA5 3309
Affinity Capture-MS Homo sapiens
61 SLC25A12 8604
Proximity Label-MS Homo sapiens
62 Cdc23  
Affinity Capture-MS Mus musculus
63 LRP4 4038
Co-fractionation Homo sapiens
64 AMBRA1  
Affinity Capture-MS Homo sapiens
65 SOX6  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 RC3H2  
Affinity Capture-MS Homo sapiens
67 C6orf15  
Affinity Capture-MS Homo sapiens
68 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 YWHAZ 7534
Affinity Capture-MS Homo sapiens
70 EGFR 1956
Negative Genetic Homo sapiens
71 NUP43 348995
Proximity Label-MS Homo sapiens
72 TST 7263
Co-fractionation Homo sapiens
73 MYO1C 4641
Affinity Capture-MS Homo sapiens
74 PIM2  
Affinity Capture-MS Homo sapiens
75 IST1 9798
Co-fractionation Homo sapiens
76 MYC  
Affinity Capture-MS Homo sapiens
77 RPA3 6119
Affinity Capture-MS Homo sapiens
78 ZCCHC6 79670
Affinity Capture-MS Homo sapiens
79 TIMM8B 26521
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
80 GPATCH8  
Affinity Capture-MS Homo sapiens
81 DDRGK1 65992
Affinity Capture-MS Homo sapiens
82 CLPB 81570
Proximity Label-MS Homo sapiens
83 FOXQ1  
Affinity Capture-MS Homo sapiens
84 XRCC3  
Affinity Capture-MS Homo sapiens
85 LMNA 4000
Proximity Label-MS Homo sapiens
86 SF3B2 10992
Affinity Capture-MS Homo sapiens
87 C3orf17  
Affinity Capture-MS Homo sapiens
88 ARHGEF7 8874
Affinity Capture-MS Homo sapiens
89 LLGL2 3993
Affinity Capture-MS Homo sapiens
90 SEC23IP 11196
Affinity Capture-MS Homo sapiens
91 PHB2 11331
Proximity Label-MS Homo sapiens
92 SLC25A6 293
Co-fractionation Homo sapiens
93 HSF4  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
94 TUBG1 7283
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 LARS2 23395
Co-fractionation Homo sapiens
96 SF3B4 10262
Co-fractionation Homo sapiens
97 EZR 7430
Affinity Capture-MS Homo sapiens
98 Myo1c 17913
Affinity Capture-MS Mus musculus
99 HNRNPA2B1 3181
Co-fractionation Homo sapiens
100 SNRPA 6626
Co-fractionation Homo sapiens
101 TIMM10  
Co-fractionation Homo sapiens
102 CAPZA2 830
Affinity Capture-MS Homo sapiens
103 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
104 HDAC1 3065
Affinity Capture-MS Homo sapiens
105 NUP35 129401
Proximity Label-MS Homo sapiens
106 CPNE1 8904
Co-fractionation Homo sapiens
107 BPTF 2186
Affinity Capture-MS Homo sapiens
108 OARD1 221443
Affinity Capture-MS Homo sapiens
109 SFXN1 94081
Proximity Label-MS Homo sapiens
110 MIF 4282
Co-fractionation Homo sapiens
111 PAX7  
Proximity Label-MS Homo sapiens
112 C9orf173  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 SLC25A51  
Proximity Label-MS Homo sapiens
114 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
115 KRAS 3845
Synthetic Lethality Homo sapiens
116 KLF11  
Two-hybrid Homo sapiens
117 YBEY  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 SP7  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TIMM13 is involved
PathwayEvidenceSource
Mitochondrial protein import IEA Reactome
Protein localization IEA Reactome





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