Gene description for Etf1
Gene name eukaryotic translation termination factor 1
Gene symbol Etf1
Other names/aliases AI463371
D6Ertd109e
ERF
ERF1
SUP45L1
TB3-1
Species Mus musculus
 Database cross references - Etf1
ExoCarta ExoCarta_225363
Vesiclepedia VP_225363
Entrez Gene 225363
UniProt Q8BWY3  
 Etf1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Etf1
Molecular Function
    translation release factor activity GO:0003747 ISO
    aminoacyl-tRNA hydrolase activity GO:0004045 IEA
    aminoacyl-tRNA hydrolase activity GO:0004045 ISO
    translation termination factor activity GO:0008079 ISO
    translation termination factor activity GO:0008079 ISS
    translation release factor activity, codon specific GO:0016149 IBA
    sequence-specific mRNA binding GO:1990825 IBA
    sequence-specific mRNA binding GO:1990825 IEA
    sequence-specific mRNA binding GO:1990825 ISO
Biological Process
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184 IEA
    cytoplasmic translational termination GO:0002184 IBA
    translational termination GO:0006415 ISO
    translational termination GO:0006415 ISO
    regulation of translational termination GO:0006449 IEA
    regulation of translational termination GO:0006449 ISO
    protein methylation GO:0006479 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytoplasm GO:0005737 NAS
    cytosol GO:0005829 IBA
    translation release factor complex GO:0018444 IBA
    translation release factor complex GO:0018444 ISO
    cytosolic ribosome GO:0022626 IEA
    cytosolic ribosome GO:0022626 ISO
 Experiment description of studies that identified Etf1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Etf1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Cyfip1 20430
Affinity Capture-MS Mus musculus
3 Eed  
Affinity Capture-MS Mus musculus
4 Psmd2 21762
Co-fractionation Mus musculus
5 Pou5f1  
Affinity Capture-MS Mus musculus
6 Fancd2  
Affinity Capture-MS Mus musculus
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