Gene description for Yes1
Gene name Yamaguchi sarcoma viral (v-yes) oncogene homolog 1
Gene symbol Yes1
Other names/aliases Yes
p61-Yes
Species Mus musculus
 Database cross references - Yes1
ExoCarta ExoCarta_22612
Vesiclepedia VP_22612
Entrez Gene 22612
UniProt Q04736  
 Yes1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Yes1
Molecular Function
    phosphotyrosine residue binding GO:0001784 IEA
    phosphotyrosine residue binding GO:0001784 ISO
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 ISO
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IEA
    signaling receptor binding GO:0005102 IBA
    epidermal growth factor receptor binding GO:0005154 ISO
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    enzyme binding GO:0019899 IEA
    enzyme binding GO:0019899 ISO
    histone H3Y41 kinase activity GO:0035401 IEA
    transmembrane transporter binding GO:0044325 IEA
    transmembrane transporter binding GO:0044325 ISO
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    regulation of D-glucose transmembrane transport GO:0010827 IDA
    cell differentiation GO:0030154 IBA
    cellular response to platelet-derived growth factor stimulus GO:0036120 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    cellular response to retinoic acid GO:0071300 IDA
    cellular response to transforming growth factor beta stimulus GO:0071560 IGI
Subcellular Localization
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    centrosome GO:0005813 IEA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 TAS
    actin filament GO:0005884 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    anchoring junction GO:0070161 IEA
    glutamatergic synapse GO:0098978 ISO
    postsynaptic specialization, intracellular component GO:0099091 ISO
 Experiment description of studies that identified Yes1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Yes1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Arrb1  
Affinity Capture-Western Mus musculus
2 Sstr3  
Proximity Label-MS Mus musculus
3 Dab1  
Affinity Capture-MS Mus musculus
4 Khdrbs1 20218
Biochemical Activity Mus musculus
5 Ednra  
Affinity Capture-Western Mus musculus
6 Diap1 13367
Affinity Capture-Western Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here