Gene description for Nrd1
Gene name nardilysin, N-arginine dibasic convertase, NRD convertase 1
Gene symbol Nrd1
Other names/aliases 2600011I06Rik
AI875733
NRD-C
Species Mus musculus
 Database cross references - Nrd1
ExoCarta ExoCarta_230598
Vesiclepedia VP_230598
Entrez Gene 230598
UniProt Q8BHG1  
 Nrd1 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Nrd1
Molecular Function
    metalloendopeptidase activity GO:0004222 IEA
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    proteolysis GO:0006508 IEA
    positive regulation of myelination GO:0031643 IMP
    positive regulation of axonogenesis GO:0050772 IMP
    positive regulation of membrane protein ectodomain proteolysis GO:0051044 IDA
    positive regulation of membrane protein ectodomain proteolysis GO:0051044 ISO
    regulation of endopeptidase activity GO:0052548 ISO
    negative regulation of cold-induced thermogenesis GO:0120163 IMP
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 ISO
    dendrite GO:0030425 IEA
 Experiment description of studies that identified Nrd1 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Nrd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
2 Elac2  
Co-fractionation Mus musculus
3 Chaf1a  
Affinity Capture-MS Mus musculus
4 Pomc  
Co-fractionation Mus musculus
5 Gfm2  
Co-fractionation Mus musculus
6 Tsn 22099
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Nrd1 is involved
No pathways found





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