Gene description for IQSEC2
Gene name IQ motif and Sec7 domain 2
Gene symbol IQSEC2
Other names/aliases BRAG1
MRX1
Species Homo sapiens
 Database cross references - IQSEC2
ExoCarta ExoCarta_23096
Vesiclepedia VP_23096
Entrez Gene 23096
HGNC 29059
MIM 300522
UniProt Q5JU85  
 IQSEC2 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for IQSEC2
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IMP
    protein binding GO:0005515 IPI
Biological Process
    actin cytoskeleton organization GO:0030036 IBA
    regulation of ARF protein signal transduction GO:0032012 IEA
    modulation of chemical synaptic transmission GO:0050804 IDA
    modulation of chemical synaptic transmission GO:0050804 IMP
    positive regulation of synapse assembly GO:0051965 IEA
    positive regulation of synaptic transmission, glutamatergic GO:0051968 IEA
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 IDA
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 IMP
    positive regulation of long-term synaptic depression GO:1900454 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
 Experiment description of studies that identified IQSEC2 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IQSEC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 THBS3 7059
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 YWHAG 7532
Affinity Capture-MS Homo sapiens
3 IQSEC1 9922
Affinity Capture-MS Homo sapiens
4 YWHAE 7531
Affinity Capture-MS Homo sapiens
5 APEX1 328
Affinity Capture-RNA Homo sapiens
6 Smad3  
Affinity Capture-MS Mus musculus
7 CALM3 808
Affinity Capture-MS Homo sapiens
8 RHOB 388
Proximity Label-MS Homo sapiens
9 ZNF460  
Affinity Capture-MS Homo sapiens
10 CCDC96  
Affinity Capture-MS Homo sapiens
11 FOXP1 27086
Protein-RNA Homo sapiens
12 YWHAB 7529
Affinity Capture-MS Homo sapiens
13 YWHAZ 7534
Affinity Capture-MS Homo sapiens
14 ACVR2B  
Affinity Capture-MS Homo sapiens
15 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
16 CALM1 801
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 RAC1 5879
Affinity Capture-MS Homo sapiens
18 CCDC8  
Affinity Capture-MS Homo sapiens
19 APBA2 321
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 XPO1 7514
Affinity Capture-MS Homo sapiens
21 FAM96A  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IQSEC2 is involved
No pathways found





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