Gene description for Aimp2
Gene name aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
Gene symbol Aimp2
Other names/aliases AA407136
AA407225
Aimp2(p38)
Jtv1
Species Mus musculus
 Database cross references - Aimp2
ExoCarta ExoCarta_231872
Vesiclepedia VP_231872
Entrez Gene 231872
UniProt Q8R010  
 Aimp2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Aimp2
Molecular Function
    protein binding GO:0005515 IPI
    molecular adaptor activity GO:0060090 IMP
Biological Process
    translation GO:0006412 IEA
    apoptotic process GO:0006915 IEA
    negative regulation of cell population proliferation GO:0008285 IDA
    protein ubiquitination GO:0016567 IDA
    positive regulation of protein ubiquitination GO:0031398 IDA
    positive regulation of neuron apoptotic process GO:0043525 ISO
    type II pneumocyte differentiation GO:0060510 IMP
    protein-containing complex assembly GO:0065003 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    aminoacyl-tRNA synthetase multienzyme complex GO:0017101 IBA
    aminoacyl-tRNA synthetase multienzyme complex GO:0017101 IMP
    aminoacyl-tRNA synthetase multienzyme complex GO:0017101 ISO
    aminoacyl-tRNA synthetase multienzyme complex GO:0017101 ISS
 Experiment description of studies that identified Aimp2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aimp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atxn1  
Affinity Capture-MS Mus musculus
2 Rars 104458
Co-fractionation Mus musculus
3 Fancd2  
Affinity Capture-MS Mus musculus
4 Atg16l1  
Affinity Capture-MS Mus musculus
5 Hars2  
Co-fractionation Mus musculus
View the network image/svg+xml



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