Gene description for ARL2BP
Gene name ADP-ribosylation factor-like 2 binding protein
Gene symbol ARL2BP
Other names/aliases BART
BART1
RP66
Species Homo sapiens
 Database cross references - ARL2BP
ExoCarta ExoCarta_23568
Vesiclepedia VP_23568
Entrez Gene 23568
HGNC 17146
MIM 615407
UniProt Q9Y2Y0  
 ARL2BP identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ARL2BP
Molecular Function
    transcription coactivator activity GO:0003713 IMP
    protein binding GO:0005515 IPI
    GTPase regulator activity GO:0030695 TAS
Biological Process
    signal transduction GO:0007165 TAS
    positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 IMP
    positive regulation of DNA-templated transcription GO:0045893 IEA
    maintenance of protein location in nucleus GO:0051457 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    mitochondrial intermembrane space GO:0005758 IBA
    mitochondrial intermembrane space GO:0005758 IDA
    mitochondrial matrix GO:0005759 TAS
    centrosome GO:0005813 IDA
    spindle GO:0005819 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    cilium GO:0005929 IEA
    midbody GO:0030496 IDA
 Experiment description of studies that identified ARL2BP in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ARL2BP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CFAP20 29105
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ARL2 402
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 ELF1 1997
Affinity Capture-MS Homo sapiens
4 Slc25a4 11739
Reconstituted Complex Mus musculus
5 HMCES  
Affinity Capture-MS Homo sapiens
6 FAS 355
Proximity Label-MS Homo sapiens
7 YWHAB 7529
Affinity Capture-MS Homo sapiens
8 ATE1 11101
Affinity Capture-MS Homo sapiens
9 YWHAE 7531
Affinity Capture-MS Homo sapiens
10 IGKC 3514
Affinity Capture-MS Homo sapiens
11 YWHAZ 7534
Affinity Capture-MS Homo sapiens
12 FSD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 USP11 8237
Affinity Capture-MS Homo sapiens
14 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
15 IGHG2 3501
Affinity Capture-MS Homo sapiens
16 POGK 57645
Affinity Capture-MS Homo sapiens
17 SHMT2 6472
Affinity Capture-RNA Homo sapiens
18 TCEAL1  
Affinity Capture-MS Homo sapiens
19 ATF1  
Affinity Capture-MS Homo sapiens
20 PNKD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 PCBP3 54039
Affinity Capture-MS Homo sapiens
22 NXF1 10482
Affinity Capture-RNA Homo sapiens
23 UBB 7314
Affinity Capture-MS Homo sapiens
24 ARL3 403
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
25 MOV10 4343
Affinity Capture-RNA Homo sapiens
26 MPP3  
Two-hybrid Homo sapiens
27 HNRNPLL 92906
Affinity Capture-MS Homo sapiens
28 PCK1 5105
Affinity Capture-MS Homo sapiens
29 YWHAQ 10971
Affinity Capture-MS Homo sapiens
30 ELF2  
Affinity Capture-MS Homo sapiens
31 CAMK2D 817
Two-hybrid Homo sapiens
32 KIAA0368 23392
Affinity Capture-MS Homo sapiens
33 RAC1 5879
Two-hybrid Homo sapiens
34 GNPAT 8443
Affinity Capture-MS Homo sapiens
35 C11orf84  
Affinity Capture-MS Homo sapiens
36 SEPN1 57190
Affinity Capture-MS Homo sapiens
37 TMPRSS13  
Affinity Capture-MS Homo sapiens
38 FAM210B  
Affinity Capture-MS Homo sapiens
39 IGHG1 3500
Affinity Capture-MS Homo sapiens
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