Gene description for ELF1
Gene name E74-like factor 1 (ets domain transcription factor)
Gene symbol ELF1
Other names/aliases -
Species Homo sapiens
 Database cross references - ELF1
ExoCarta ExoCarta_1997
Vesiclepedia VP_1997
Entrez Gene 1997
HGNC 3316
MIM 189973
UniProt P32519  
 ELF1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ELF1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA-binding transcription factor activity GO:0003700 IDA
    protein binding GO:0005515 IPI
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    regulation of cytokine production GO:0001817 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    cell differentiation GO:0030154 IBA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    negative regulation of T cell receptor signaling pathway GO:0050860 IEA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IC
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified ELF1 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ELF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCRS1  
Proximity Label-MS Homo sapiens
2 MBTD1  
Proximity Label-MS Homo sapiens
3 FEV  
Proximity Label-MS Homo sapiens
4 TRRAP 8295
Proximity Label-MS Homo sapiens
5 SP1  
Reconstituted Complex Homo sapiens
6 REL 5966
Reconstituted Complex Homo sapiens
7 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
8 BRD7  
Proximity Label-MS Homo sapiens
9 TAF3 83860
Proximity Label-MS Homo sapiens
10 ZZZ3  
Proximity Label-MS Homo sapiens
11 KANSL3  
Proximity Label-MS Homo sapiens
12 TAF1  
Proximity Label-MS Homo sapiens
13 TAF5  
Proximity Label-MS Homo sapiens
14 NFKB1 4790
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
15 SRCAP  
Proximity Label-MS Homo sapiens
16 C11orf30  
Proximity Label-MS Homo sapiens
17 VPS72  
Proximity Label-MS Homo sapiens
18 KLF8  
Proximity Label-MS Homo sapiens
19 E2F6 1876
Proximity Label-MS Homo sapiens
20 ZNF148  
Proximity Label-MS Homo sapiens
21 ARID4B  
Proximity Label-MS Homo sapiens
22 HMGA1 3159
Reconstituted Complex Homo sapiens
23 HCFC2  
Proximity Label-MS Homo sapiens
24 NR2C1  
Proximity Label-MS Homo sapiens
25 SETD1A 9739
Proximity Label-MS Homo sapiens
26 SMARCA2 6595
Proximity Label-MS Homo sapiens
27 NFIX 4784
Proximity Label-MS Homo sapiens
28 KANSL1  
Proximity Label-MS Homo sapiens
29 KLF16  
Proximity Label-MS Homo sapiens
30 HSPBP1 23640
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CXXC1  
Proximity Label-MS Homo sapiens
32 PHF10  
Proximity Label-MS Homo sapiens
33 FOXC1  
Affinity Capture-MS Homo sapiens
34 ASH2L 9070
Proximity Label-MS Homo sapiens
35 NFRKB  
Proximity Label-MS Homo sapiens
36 ARL2BP 23568
Affinity Capture-MS Homo sapiens
37 RBM28 55131
Proximity Label-MS Homo sapiens
38 BRMS1 25855
Proximity Label-MS Homo sapiens
39 HIVEP1 3096
Proximity Label-MS Homo sapiens
40 LRIF1  
Proximity Label-MS Homo sapiens
41 TRIM24  
Proximity Label-MS Homo sapiens
42 NFIA 4774
Proximity Label-MS Homo sapiens
43 ZHX2  
Proximity Label-MS Homo sapiens
44 POGZ 23126
Proximity Label-MS Homo sapiens
45 TAF12  
Proximity Label-MS Homo sapiens
46 FOXK2  
Proximity Label-MS Homo sapiens
47 BPTF 2186
Proximity Label-MS Homo sapiens
48 ZNF131  
Proximity Label-MS Homo sapiens
49 CCDC101  
Proximity Label-MS Homo sapiens
50 SMC1A 8243
Proximity Label-MS Homo sapiens
51 MRPL11 65003
Proximity Label-MS Homo sapiens
52 L3MBTL2  
Proximity Label-MS Homo sapiens
53 CEBPA  
Proximity Label-MS Homo sapiens
54 ING2  
Proximity Label-MS Homo sapiens
55 ZMYM4  
Proximity Label-MS Homo sapiens
56 YEATS4  
Proximity Label-MS Homo sapiens
57 ZNF644  
Proximity Label-MS Homo sapiens
58 ECH1 1891
Proximity Label-MS Homo sapiens
59 ASXL2  
Proximity Label-MS Homo sapiens
60 SMCHD1 23347
Proximity Label-MS Homo sapiens
61 KMT2A  
Proximity Label-MS Homo sapiens
62 MGA  
Proximity Label-MS Homo sapiens
63 S100A8 6279
Proximity Label-MS Homo sapiens
64 YY1 7528
Proximity Label-MS Homo sapiens
65 H1F0 3005
Cross-Linking-MS (XL-MS) Homo sapiens
66 KANSL2  
Proximity Label-MS Homo sapiens
67 EP400  
Proximity Label-MS Homo sapiens
68 BAP1 8314
Proximity Label-MS Homo sapiens
69 MORF4L1  
Proximity Label-MS Homo sapiens
70 BRMS1L  
Proximity Label-MS Homo sapiens
71 TBP  
Proximity Label-MS Homo sapiens
72 ACTR6  
Proximity Label-MS Homo sapiens
73 ACTR5 79913
Proximity Label-MS Homo sapiens
74 TADA2A  
Proximity Label-MS Homo sapiens
75 INO80  
Proximity Label-MS Homo sapiens
76 ZNF687  
Proximity Label-MS Homo sapiens
77 HNRNPUL1 11100
Affinity Capture-MS Homo sapiens
78 NFYA 4800
Reconstituted Complex Homo sapiens
79 RBBP5 5929
Proximity Label-MS Homo sapiens
80 KAT2A  
Proximity Label-MS Homo sapiens
81 FOXK1 221937
Proximity Label-MS Homo sapiens
82 FHL2 2274
Affinity Capture-MS Homo sapiens
83 TAF4 6874
Proximity Label-MS Homo sapiens
84 RBM11  
Proximity Label-MS Homo sapiens
85 TAF6 6878
Proximity Label-MS Homo sapiens
86 KAT8  
Proximity Label-MS Homo sapiens
87 ARID2  
Proximity Label-MS Homo sapiens
88 PHF12  
Proximity Label-MS Homo sapiens
89 KMT2B  
Proximity Label-MS Homo sapiens
90 ATXN1L  
Proximity Label-MS Homo sapiens
91 KAT2B  
Proximity Label-MS Homo sapiens
92 KLF3  
Proximity Label-MS Homo sapiens
93 PBRM1 55193
Proximity Label-MS Homo sapiens
94 GRPEL1 80273
Proximity Label-MS Homo sapiens
95 EPC1  
Proximity Label-MS Homo sapiens
96 TAF2  
Proximity Label-MS Homo sapiens
97 ATF1  
Proximity Label-MS Homo sapiens
98 PWP1 11137
Proximity Label-MS Homo sapiens
99 KDM1B  
Proximity Label-MS Homo sapiens
100 PCGF6  
Proximity Label-MS Homo sapiens
101 KLHL6  
Affinity Capture-MS Homo sapiens
102 LIN54  
Proximity Label-MS Homo sapiens
103 ELF2  
Proximity Label-MS Homo sapiens
104 GATAD1  
Proximity Label-MS Homo sapiens
105 GABPA 2551
Proximity Label-MS Homo sapiens
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