Gene description for NFKB1
Gene name nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Gene symbol NFKB1
Other names/aliases EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
Species Homo sapiens
 Database cross references - NFKB1
ExoCarta ExoCarta_4790
Vesiclepedia VP_4790
Entrez Gene 4790
HGNC 7794
MIM 164011
UniProt P19838  
 NFKB1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NFKB1
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IMP
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IMP
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    chromatin binding GO:0003682 IEA
    DNA-binding transcription factor activity GO:0003700 IDA
    transcription coregulator activity GO:0003712 IEA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    actinin binding GO:0042805 IPI
    protein sequestering activity GO:0140311 IDA
    protein sequestering activity GO:0140311 ISS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IC
    negative regulation of transcription by RNA polymerase II GO:0000122 IGI
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    transcription by RNA polymerase II GO:0006366 TAS
    apoptotic process GO:0006915 IEA
    inflammatory response GO:0006954 TAS
    canonical NF-kappaB signal transduction GO:0007249 IDA
    JNK cascade GO:0007254 IEA
    negative regulation of gene expression GO:0010629 IDA
    positive regulation of macrophage derived foam cell differentiation GO:0010744 IC
    positive regulation of lipid storage GO:0010884 IC
    negative regulation of calcidiol 1-monooxygenase activity GO:0010956 IDA
    negative regulation of vitamin D biosynthetic process GO:0010957 IC
    negative regulation of cholesterol transport GO:0032375 IC
    negative regulation of interleukin-12 production GO:0032695 IEA
    response to muscle stretch GO:0035994 IEA
    non-canonical NF-kappaB signal transduction GO:0038061 IDA
    negative regulation of apoptotic process GO:0043066 TAS
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of DNA-templated transcription GO:0045893 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    negative regulation of inflammatory response GO:0050728 IDA
    B cell receptor signaling pathway GO:0050853 IEA
    negative regulation of protein metabolic process GO:0051248 IC
    mammary gland involution GO:0060056 IEA
    positive regulation of transcription initiation by RNA polymerase II GO:0060261 IEA
    cellular response to lipopolysaccharide GO:0071222 IMP
    cellular response to mechanical stimulus GO:0071260 IEP
    cellular response to nicotine GO:0071316 IMP
    cellular response to interleukin-1 GO:0071347 IEP
    cellular response to interleukin-6 GO:0071354 IMP
    cellular response to tumor necrosis factor GO:0071356 IEA
    cellular response to dsRNA GO:0071359 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IMP
    cellular response to interleukin-17 GO:0097398 IEA
    cellular response to virus GO:0098586 IEA
    antibacterial innate immune response GO:0140367 IDA
    positive regulation of hyaluronan biosynthetic process GO:1900127 IDA
    cellular response to angiotensin GO:1904385 IMP
    positive regulation of miRNA metabolic process GO:2000630 IMP
Subcellular Localization
    chromatin GO:0000785 IC
    chromatin GO:0000785 IDA
    chromatin GO:0000785 ISA
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IGI
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IEA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 IGI
    cytoplasm GO:0005737 ISS
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    I-kappaB/NF-kappaB complex GO:0033256 TAS
    secretory granule lumen GO:0034774 TAS
    NF-kappaB p50/p65 complex GO:0035525 IBA
    specific granule lumen GO:0035580 TAS
 Experiment description of studies that identified NFKB1 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
6
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NFKB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATAD1 84896
Affinity Capture-MS Homo sapiens
2 CNOT7 29883
Affinity Capture-MS Homo sapiens
3 RPS6KA5 9252
Affinity Capture-Western Homo sapiens
4 NCOA6  
Reconstituted Complex Homo sapiens
5 HDAC4  
Affinity Capture-Western Homo sapiens
6 TNIP1 10318
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
7 HOOK1  
Proximity Label-MS Homo sapiens
8 POLR2H 5437
Co-fractionation Homo sapiens
9 KPNA3 3839
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
10 HDAC2 3066
Affinity Capture-Western Homo sapiens
11 ELF1 1997
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
12 FBXO7 25793
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
13 CDKN1A  
Affinity Capture-Western Homo sapiens
14 STAT5A 6776
Affinity Capture-Western Homo sapiens
15 PSMA4 5685
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 PSMD11 5717
Co-fractionation Homo sapiens
17 CNOT11 55571
Affinity Capture-MS Homo sapiens
18 SP1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 REL 5966
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
20 E2F1 1869
Reconstituted Complex Homo sapiens
21 HSPA1L 3305
Co-localization Homo sapiens
22 COMMD9 29099
Affinity Capture-Western Homo sapiens
23 HSP90AB1 3326
Co-localization Homo sapiens
24 CHEK2  
Two-hybrid Homo sapiens
25 KPNA2 3838
Co-fractionation Homo sapiens
26 PSMD10 5716
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 KAT5  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
28 RPS3 6188
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
29 DPF1  
Affinity Capture-Western Homo sapiens
30 LRPPRC 10128
Co-fractionation Homo sapiens
31 NFKB1 4790
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Luminescence Homo sapiens
32 VPS26A 9559
Affinity Capture-MS Homo sapiens
33 CAPZB 832
Co-fractionation Homo sapiens
34 HDAC3 8841
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
35 NCOR1  
Affinity Capture-Western Homo sapiens
36 NCBP1 4686
Co-fractionation Homo sapiens
37 PTGS2 5743
Positive Genetic Homo sapiens
38 DYNC1LI2 1783
Co-fractionation Homo sapiens
39 CLU 1191
Affinity Capture-Western Homo sapiens
40 MXD3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
41 APBB2  
Reconstituted Complex Homo sapiens
42 COPS6 10980
Affinity Capture-MS Homo sapiens
43 GNS 2799
Co-fractionation Homo sapiens
44 COPB2 9276
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
45 KIF5B 3799
Co-fractionation Homo sapiens
46 SPAG9 9043
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 GEMIN5 25929
Co-fractionation Homo sapiens
48 COPS5 10987
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
49 IMPDH2 3615
Co-fractionation Homo sapiens
50 HGS 9146
Proximity Label-MS Homo sapiens
51 STAT3 6774
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
52 MTMR2 8898
Affinity Capture-MS Homo sapiens
53 NCOA3  
Affinity Capture-Western Homo sapiens
54 HMGA1 3159
Reconstituted Complex Homo sapiens
55 CNOT6  
Affinity Capture-MS Homo sapiens
56 HMGA2 8091
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
57 BIRC3 330
Co-localization Homo sapiens
58 COMMD10 51397
Affinity Capture-Western Homo sapiens
59 ABCC2 1244
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
60 CUL1 8454
Co-fractionation Homo sapiens
61 POLR1E  
Co-fractionation Homo sapiens
62 SOCS3 9021
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
63 BTRC 8945
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
64 NPAS1  
Affinity Capture-MS Homo sapiens
65 RNF123 63891
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
66 STAT6 6778
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
67 COMMD4 54939
Affinity Capture-Western Homo sapiens
68 GSK3B 2932
Biochemical Activity Homo sapiens
69 NCOA1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
70 GTF2I 2969
Co-fractionation Homo sapiens
71 TFAP2A  
Two-hybrid Homo sapiens
72 XRCC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 AURKA 6790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 BANP  
Affinity Capture-Western Homo sapiens
75 PHF10  
Affinity Capture-Western Homo sapiens
76 RPL30 6156
Co-fractionation Homo sapiens
77 LYL1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
78 CNOT2  
Affinity Capture-MS Homo sapiens
79 HTATIP2 10553
Co-fractionation Homo sapiens
80 CUL4B 8450
Affinity Capture-MS Homo sapiens
81 PCBD1 5092
Two-hybrid Homo sapiens
82 IRF2 3660
Reconstituted Complex Homo sapiens
83 NOV 4856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 BRMS1 25855
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
85 NCOR2  
Co-localization Homo sapiens
86 ILVBL 10994
Affinity Capture-MS Homo sapiens
87 TNKS1BP1 85456
Affinity Capture-MS Homo sapiens
88 EXOC4 60412
Proximity Label-MS Homo sapiens
89 ITGB3BP  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
90 HIF1AN 55662
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
91 CARM1 10498
Co-purification Homo sapiens
Co-fractionation Homo sapiens
92 CCR1  
Affinity Capture-MS Homo sapiens
93 ZHX2  
Affinity Capture-Western Homo sapiens
94 BARD1 580
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
95 DPF2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
96 KLF5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
97 TAB2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
98 IL10RA  
Positive Genetic Homo sapiens
99 CHEK1  
Affinity Capture-Western Homo sapiens
100 CNOT6L 246175
Affinity Capture-MS Homo sapiens
101 SRF  
Reconstituted Complex Homo sapiens
102 BICD2 23299
Proximity Label-MS Homo sapiens
103 YWHAQ 10971
Two-hybrid Homo sapiens
104 NFYC 4802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 RGS14  
Two-hybrid Homo sapiens
106 PML 5371
Two-hybrid Homo sapiens
107 ACBD5 91452
Proximity Label-MS Homo sapiens
108 UBE2D3 7323
Biochemical Activity Homo sapiens
109 KLC1 3831
Co-fractionation Homo sapiens
110 TNIP3  
Affinity Capture-MS Homo sapiens
111 SPPL2A 84888
Two-hybrid Homo sapiens
112 PELP1 27043
Reconstituted Complex Homo sapiens
113 NFKB2 4791
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
114 SERPINA3 12
Two-hybrid Homo sapiens
115 HDAC5 10014
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
116 COMMD3 23412
Affinity Capture-Western Homo sapiens
117 TEAD4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
118 UBXN6 80700
Affinity Capture-MS Homo sapiens
119 VCP 7415
Affinity Capture-Western Homo sapiens
120 CD3EAP  
Co-fractionation Homo sapiens
121 LARP1 23367
Co-fractionation Homo sapiens
122 NFKBIE  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 NKRF 55922
Reconstituted Complex Homo sapiens
124 IRF9 10379
Reconstituted Complex Homo sapiens
125 NR4A1  
Two-hybrid Homo sapiens
126 SF1 7536
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
127 DHX15 1665
Co-fractionation Homo sapiens
128 TP53BP1 7158
Affinity Capture-Western Homo sapiens
129 XPO1 7514
Affinity Capture-MS Homo sapiens
130 DNMT3L  
Reconstituted Complex Homo sapiens
131 COMMD8 54951
Affinity Capture-Western Homo sapiens
132 PPARG 5468
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
133 GGH 8836
Affinity Capture-MS Homo sapiens
134 CTNNB1 1499
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
135 NFKBIA  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
136 MEX3A  
Affinity Capture-RNA Homo sapiens
137 ANXA4 307
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
138 ANKRD32  
Proximity Label-MS Homo sapiens
139 CUL3 8452
Affinity Capture-MS Homo sapiens
140 NR3C1 2908
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
141 HMGB1 3146
Reconstituted Complex Homo sapiens
142 HOOK3 84376
Proximity Label-MS Homo sapiens
143 BCL3  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
144 MAP3K8  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
145 METTL21B  
Affinity Capture-MS Homo sapiens
146 MYC  
Affinity Capture-Western Homo sapiens
147 MTIF2 4528
Co-fractionation Homo sapiens
148 POLR2A 5430
Co-localization Homo sapiens
149 TNIP2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
FRET Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 YY1 7528
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
151 JUN 3725
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
152 PPP4C 5531
Affinity Capture-Western Homo sapiens
153 UBE2D2 7322
Biochemical Activity Homo sapiens
154 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
155 PADI3 51702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 PIK3CA 5290
Positive Genetic Homo sapiens
157 JAK1 3716
Positive Genetic Homo sapiens
158 ARL4D  
Affinity Capture-MS Homo sapiens
159 COMMD6 170622
Affinity Capture-Western Homo sapiens
160 TP63  
Affinity Capture-Western Homo sapiens
161 ETS1  
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
162 HSPA4 3308
Reconstituted Complex Homo sapiens
163 COMMD2 51122
Affinity Capture-Western Homo sapiens
164 MPP6 51678
Reconstituted Complex Homo sapiens
165 HSPA9 3313
Co-fractionation Homo sapiens
166 ADRM1 11047
Co-fractionation Homo sapiens
167 TSC22D3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
168 CHUK 1147
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
169 ZBTB9  
Two-hybrid Homo sapiens
170 CD82 3732
Co-localization Homo sapiens
171 PPME1 51400
Affinity Capture-MS Homo sapiens
172 DPF3  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
173 COMMD1 150684
Affinity Capture-Western Homo sapiens
174 STUB1 10273
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
175 RELA 5970
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
176 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
177 PARP1 142
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
178 ZFP36  
Affinity Capture-Western Homo sapiens
179 POLR1B 84172
Co-fractionation Homo sapiens
180 MTPN 136319
Reconstituted Complex Homo sapiens
181 RPL6 6128
Co-fractionation Homo sapiens
182 NFKBIZ  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
183 RBM25 58517
Co-fractionation Homo sapiens
184 RUVBL2 10856
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
185 PPP1R13L 10848
Affinity Capture-MS Homo sapiens
186 IQGAP2 10788
Co-fractionation Homo sapiens
187 DDX3X 1654
Co-fractionation Homo sapiens
188 COMMD5 28991
Affinity Capture-Western Homo sapiens
189 MEN1 4221
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
190 CUL5 8065
Affinity Capture-MS Homo sapiens
191 SKP1 6500
Co-fractionation Homo sapiens
192 IKBKB 3551
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
193 SMAD4  
Affinity Capture-MS Homo sapiens
194 HIST1H1E 3008
Co-fractionation Homo sapiens
195 TRIM9  
Proximity Label-MS Homo sapiens
196 HDAC1 3065
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
197 POLR1A 25885
Co-fractionation Homo sapiens
198 POU2F1 5451
Co-fractionation Homo sapiens
199 DYNC1H1 1778
Co-fractionation Homo sapiens
200 ELF3 1999
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
201 NFKBID  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
202 TBK1 29110
Affinity Capture-MS Homo sapiens
203 TXN 7295
Co-crystal Structure Homo sapiens
204 PLD3 23646
Reconstituted Complex Homo sapiens
205 GLUL 2752
Two-hybrid Homo sapiens
206 TRIP4 9325
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
207 RXRA 6256
Reconstituted Complex Homo sapiens
208 TRIM28 10155
Co-fractionation Homo sapiens
209 RELB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 HNRNPF 3185
Co-fractionation Homo sapiens
211 CEBPB  
Reconstituted Complex Homo sapiens
212 CDX2  
Affinity Capture-Western Homo sapiens
213 UNC5CL  
Affinity Capture-Western Homo sapiens
214 PPP1CB 5500
Co-fractionation Homo sapiens
215 NFKBIB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
216 RSF1  
Affinity Capture-Western Homo sapiens
217 GLG1 2734
Co-fractionation Homo sapiens
218 PPARGC1A  
Affinity Capture-Western Homo sapiens
219 NOTCH1 4851
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
220 TOP1MT  
Affinity Capture-MS Homo sapiens
221 CUL4A 8451
Affinity Capture-MS Homo sapiens
222 EP300 2033
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
223 ECSIT 51295
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
224 IKBKG 8517
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
225 IRF8  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which NFKB1 is involved
PathwayEvidenceSource
Activation of NF-kappaB in B cells TAS Reactome
Adaptive Immune System TAS Reactome
Adipogenesis IEA Reactome
C-type lectin receptors (CLRs) TAS Reactome
CD209 (DC-SIGN) signaling TAS Reactome
Cell recruitment (pro-inflammatory response) TAS Reactome
Cellular response to chemical stress TAS Reactome
Cellular responses to mechanical stimuli TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
CLEC7A (Dectin-1) signaling TAS Reactome
CLEC7A/inflammasome pathway TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytosolic sensors of pathogen-associated DNA TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta TAS Reactome
Death Receptor Signaling TAS Reactome
Developmental Biology IEA Reactome
DEx/H-box helicases activate type I IFN and inflammatory cytokines production TAS Reactome
Disease TAS Reactome
Diseases associated with the TLR signaling cascade TAS Reactome
Diseases of Immune System TAS Reactome
Downstream signaling events of B Cell Receptor (BCR) TAS Reactome
Downstream TCR signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated NF-kB activation TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
IkBA variant leads to EDA-ID TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Inflammasomes TAS Reactome
Innate Immune System TAS Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-1 processing TAS Reactome
Interleukin-1 signaling TAS Reactome
Interleukin-17 signaling TAS Reactome
KEAP1-NFE2L2 pathway TAS Reactome
Leishmania infection TAS Reactome
MAP kinase activation TAS Reactome
MAP3K8 (TPL2)-dependent MAPK1/3 activation TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
Neutrophil degranulation TAS Reactome
NF-kB is activated and signals survival TAS Reactome
Nuclear events mediated by NFE2L2 TAS Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TAS Reactome
p75 NTR receptor-mediated signalling TAS Reactome
p75NTR signals via NF-kB TAS Reactome
Parasitic Infection Pathways TAS Reactome
PKMTs methylate histone lysines TAS Reactome
Purinergic signaling in leishmaniasis infection TAS Reactome
Regulated proteolysis of p75NTR TAS Reactome
Regulation of NFE2L2 gene expression TAS Reactome
Response of endothelial cells to shear stress TAS Reactome
RIP-mediated NFkB activation via ZBP1 TAS Reactome
RNA Polymerase II Transcription TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-1 activates/modulates innate immune responses TAS Reactome
SARS-CoV-1 Infection TAS Reactome
SARS-CoV-1-host interactions TAS Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
TAK1-dependent IKK and NF-kappa-B activation TAS Reactome
TCR signaling TAS Reactome
The NLRP3 inflammasome TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRAF6 mediated NF-kB activation TAS Reactome
Transcriptional Regulation by VENTX TAS Reactome
Transcriptional regulation of white adipocyte differentiation IEA Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells TAS Reactome
Viral Infection Pathways TAS Reactome
ZBP1(DAI) mediated induction of type I IFNs TAS Reactome





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