Gene description for COMMD4
Gene name COMM domain containing 4
Gene symbol COMMD4
Other names/aliases -
Species Homo sapiens
 Database cross references - COMMD4
ExoCarta ExoCarta_54939
Vesiclepedia VP_54939
Entrez Gene 54939
HGNC 26027
UniProt Q9H0A8  
 COMMD4 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for COMMD4
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    signal transduction GO:0007165 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified COMMD4 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COMMD4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPSAP58 388524
Affinity Capture-MS Homo sapiens
2 CCDC151  
Affinity Capture-MS Homo sapiens
3 ARHGAP17 55114
Co-fractionation Homo sapiens
4 PFKP 5214
Co-fractionation Homo sapiens
5 NUP62 23636
Affinity Capture-MS Homo sapiens
6 SUB1 10923
Affinity Capture-MS Homo sapiens
7 BUB1B  
Two-hybrid Homo sapiens
8 VPS29 51699
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ARHGDIA 396
Co-fractionation Homo sapiens
10 ITPR3 3710
Affinity Capture-MS Homo sapiens
11 C16orf62 57020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 EXOSC2 23404
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 KIF23 9493
Affinity Capture-MS Homo sapiens
14 SF3B1 23451
Affinity Capture-MS Homo sapiens
15 COMMD9 29099
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 E2F6 1876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PRC1 9055
Affinity Capture-MS Homo sapiens
18 PFDN4 5203
Co-fractionation Homo sapiens
19 RSRC1  
Affinity Capture-MS Homo sapiens
20 EXOSC4 54512
Affinity Capture-MS Homo sapiens
21 UCHL5 51377
Co-fractionation Homo sapiens
22 COMMD10 51397
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 DDX6 1656
Co-fractionation Homo sapiens
24 ARGLU1  
Affinity Capture-MS Homo sapiens
25 GPATCH2  
Affinity Capture-MS Homo sapiens
26 OR13G1  
Affinity Capture-MS Homo sapiens
27 CHERP 10523
Affinity Capture-MS Homo sapiens
28 KIF14 9928
Affinity Capture-MS Homo sapiens
29 CCDC114  
Affinity Capture-MS Homo sapiens
30 TSHR 7253
Affinity Capture-MS Homo sapiens
31 PFKM 5213
Co-fractionation Homo sapiens
32 RAD23B 5887
Co-fractionation Homo sapiens
33 GGT7 2686
Affinity Capture-MS Homo sapiens
34 TUBA1A 7846
Affinity Capture-MS Homo sapiens
35 SRSF6 6431
Affinity Capture-MS Homo sapiens
36 TFDP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 RBMX2  
Affinity Capture-MS Homo sapiens
38 CCDC22 28952
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 TRIM72  
Affinity Capture-MS Homo sapiens
40 COMMD3 23412
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 DSCR3 10311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ANLN 54443
Affinity Capture-MS Homo sapiens
43 SF3B2 10992
Affinity Capture-MS Homo sapiens
44 FAM45A 404636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 Ranbp1 19385
Affinity Capture-MS Mus musculus
46 SUGP1  
Affinity Capture-MS Homo sapiens
47 ZHX1-C8orf76  
Affinity Capture-MS Homo sapiens
48 STMN2  
Affinity Capture-MS Homo sapiens
49 TIPRL 261726
Co-fractionation Homo sapiens
50 KIF20A 10112
Affinity Capture-MS Homo sapiens
51 ECT2 1894
Affinity Capture-MS Homo sapiens
52 DHX15 1665
Affinity Capture-MS Homo sapiens
53 COMMD8 54951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
54 ATP6V1D 51382
Co-fractionation Homo sapiens
55 CDK19 23097
Co-fractionation Homo sapiens
56 COMMD2 51122
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 PACSIN3 29763
Affinity Capture-MS Homo sapiens
58 CNKSR3 154043
Affinity Capture-MS Homo sapiens
59 SPACA1 81833
Affinity Capture-MS Homo sapiens
60 PSPC1 55269
Affinity Capture-MS Homo sapiens
61 MCMBP 79892
Co-fractionation Homo sapiens
62 COMMD6 170622
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 NPEPL1 79716
Co-fractionation Homo sapiens
64 NFKB1 4790
Affinity Capture-Western Homo sapiens
65 TP53RK 112858
Affinity Capture-MS Homo sapiens
66 SKIV2L2 23517
Affinity Capture-MS Homo sapiens
67 APEX2  
Affinity Capture-MS Homo sapiens
68 SUPT16H 11198
Affinity Capture-MS Homo sapiens
69 RBM17 84991
Affinity Capture-MS Homo sapiens
70 COMMD1 150684
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
71 U2SURP 23350
Affinity Capture-MS Homo sapiens
72 RELA 5970
Affinity Capture-Western Homo sapiens
73 COX20  
Affinity Capture-MS Homo sapiens
74 SULT1A1 6817
Co-fractionation Homo sapiens
75 COMMD5 28991
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 CWF19L2  
Affinity Capture-MS Homo sapiens
77 CCDC97  
Affinity Capture-MS Homo sapiens
78 CCDC93 54520
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 TRIM25 7706
Co-fractionation Homo sapiens
80 COMMD3-BMI1 100532731
Affinity Capture-MS Homo sapiens
81 TFDP2  
Affinity Capture-MS Homo sapiens
82 RELB  
Affinity Capture-Western Homo sapiens
83 CIT 11113
Affinity Capture-MS Homo sapiens
84 SSRP1 6749
Affinity Capture-MS Homo sapiens
85 COMMD7 149951
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 CDK11A 728642
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which COMMD4 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Neddylation TAS Reactome
Post-translational protein modification TAS Reactome





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