Gene description for RBM17
Gene name RNA binding motif protein 17
Gene symbol RBM17
Other names/aliases SPF45
Species Homo sapiens
 Database cross references - RBM17
ExoCarta ExoCarta_84991
Vesiclepedia VP_84991
Entrez Gene 84991
HGNC 16944
MIM 606935
UniProt Q96I25  
 RBM17 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RBM17
Molecular Function
    RNA binding GO:0003723 IEA
    protein binding GO:0005515 IPI
Biological Process
    alternative mRNA splicing, via spliceosome GO:0000380 IBA
    alternative mRNA splicing, via spliceosome GO:0000380 IMP
    mRNA cis splicing, via spliceosome GO:0045292 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    spliceosomal complex GO:0005681 IEA
 Experiment description of studies that identified RBM17 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RBM17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 CCAR1 55749
Affinity Capture-MS Homo sapiens
3 SNRPG 6637
Affinity Capture-MS Homo sapiens
4 SNRPE 6635
Affinity Capture-MS Homo sapiens
5 DNAJC8 22826
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
6 PPIE 10450
Affinity Capture-MS Homo sapiens
7 CEP55 55165
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 FAM9B  
Two-hybrid Homo sapiens
9 ACTC1 70
Proximity Label-MS Homo sapiens
10 DHX8 1659
Proximity Label-MS Homo sapiens
11 RPS19 6223
Affinity Capture-MS Homo sapiens
12 KIF20A 10112
Affinity Capture-MS Homo sapiens
13 C19orf43  
Affinity Capture-MS Homo sapiens
14 CSNK2A1 1457
Biochemical Activity Homo sapiens
15 PRPF3  
Affinity Capture-MS Homo sapiens
16 APBB1  
Reconstituted Complex Homo sapiens
17 SNRPF 6636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SNRPD2 6633
Affinity Capture-MS Homo sapiens
19 RPS3 6188
Affinity Capture-MS Homo sapiens
20 CCDC170  
Two-hybrid Homo sapiens
21 DPPA4  
Affinity Capture-MS Homo sapiens
22 DDX23 9416
Proximity Label-MS Homo sapiens
23 KIF23 9493
Affinity Capture-MS Homo sapiens
24 SF3B1 23451
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 Htatsf1  
Two-hybrid Mus musculus
26 PPP3CB  
Affinity Capture-MS Homo sapiens
27 PRC1 9055
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
28 MDC1  
Affinity Capture-MS Homo sapiens
29 POU5F1  
Affinity Capture-MS Homo sapiens
30 OBSL1 23363
Affinity Capture-MS Homo sapiens
31 SF3A2 8175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 MKI67  
Affinity Capture-MS Homo sapiens
33 HINFP  
Two-hybrid Homo sapiens
34 TUBA3C 7278
Affinity Capture-MS Homo sapiens
35 MECP2 4204
Affinity Capture-MS Homo sapiens
36 MYCN  
Affinity Capture-MS Homo sapiens
37 CSNK2B 1460
Affinity Capture-MS Homo sapiens
38 COMMD4 54939
Affinity Capture-MS Homo sapiens
39 RPS2 6187
Affinity Capture-MS Homo sapiens
40 KIF14 9928
Affinity Capture-MS Homo sapiens
41 HSPA8 3312
Affinity Capture-MS Homo sapiens
42 LIN28A  
Affinity Capture-MS Homo sapiens
43 ACTA2 59
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TOLLIP 54472
Proximity Label-MS Homo sapiens
45 PCNP 57092
Affinity Capture-MS Homo sapiens
46 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
47 DDX21 9188
Affinity Capture-MS Homo sapiens
48 RPS10 6204
Affinity Capture-MS Homo sapiens
49 GOLGA2 2801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
50 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
51 RPL35 11224
Affinity Capture-MS Homo sapiens
52 KIAA1683  
Two-hybrid Homo sapiens
53 SNRPD1 6632
Affinity Capture-MS Homo sapiens
54 BARD1 580
Affinity Capture-MS Homo sapiens
55 OGT 8473
Reconstituted Complex Homo sapiens
56 U2AF2 11338
Co-fractionation Homo sapiens
57 RAD18  
Affinity Capture-MS Homo sapiens
58 ARRDC3 57561
Affinity Capture-MS Homo sapiens
59 RPA4  
Proximity Label-MS Homo sapiens
60 DHX9 1660
Affinity Capture-MS Homo sapiens
61 ZRSR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 HNRNPL 3191
Affinity Capture-MS Homo sapiens
63 SON 6651
Co-fractionation Homo sapiens
64 DDX39B 7919
Affinity Capture-MS Homo sapiens
65 ACTBL2 345651
Affinity Capture-MS Homo sapiens
66 SAT1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
67 CEBPA  
Protein-peptide Homo sapiens
68 CYLD  
Affinity Capture-MS Homo sapiens
69 SF3A3 10946
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 PPP1R12C 54776
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
71 GPATCH11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 RBM10  
Affinity Capture-MS Homo sapiens
73 SNRPB2 6629
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
74 RSL1D1 26156
Affinity Capture-MS Homo sapiens
75 RBM5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 SUGP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
77 SAP30BP  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
78 KDM4D  
Affinity Capture-MS Homo sapiens
79 CHERP 10523
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 XPO1 7514
Affinity Capture-MS Homo sapiens
81 ECT2 1894
Affinity Capture-MS Homo sapiens
82 SNRPB 6628
Co-fractionation Homo sapiens
83 CTNNB1 1499
Affinity Capture-MS Homo sapiens
84 CUL3 8452
Affinity Capture-MS Homo sapiens
85 EGFR 1956
Negative Genetic Homo sapiens
86 SF1 7536
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
87 SART1 9092
Affinity Capture-MS Homo sapiens
88 MYO1C 4641
Affinity Capture-MS Homo sapiens
89 SF3A1 10291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 CDK2 1017
Affinity Capture-MS Homo sapiens
91 PCBP1 5093
Affinity Capture-MS Homo sapiens
92 DKC1 1736
Affinity Capture-MS Homo sapiens
93 MYC  
Affinity Capture-MS Homo sapiens
94 RPA3 6119
Proximity Label-MS Homo sapiens
95 EMC2 9694
Affinity Capture-MS Homo sapiens
96 COMMD6 170622
Affinity Capture-MS Homo sapiens
97 COMMD2 51122
Affinity Capture-MS Homo sapiens
98 Junb  
Affinity Capture-MS Mus musculus
99 DDRGK1 65992
Affinity Capture-MS Homo sapiens
100 SF3B3 23450
Affinity Capture-MS Homo sapiens
101 XRCC3  
Affinity Capture-MS Homo sapiens
102 HSPD1 3329
Co-fractionation Homo sapiens
103 NANOG  
Affinity Capture-MS Homo sapiens
104 SF3B2 10992
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 GNL3 26354
Affinity Capture-MS Homo sapiens
106 COMMD1 150684
Affinity Capture-MS Homo sapiens
107 U2SURP 23350
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 HECTD1 25831
Affinity Capture-MS Homo sapiens
109 DHX15 1665
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
110 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
111 WDFY2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 LNX2  
Two-hybrid Homo sapiens
113 CCHCR1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
114 SF3B4 10262
Affinity Capture-MS Homo sapiens
115 ZRSR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 MEN1 4221
Affinity Capture-MS Homo sapiens
117 SMNDC1  
Co-fractionation Homo sapiens
118 SMURF1 57154
Affinity Capture-MS Homo sapiens
119 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
120 Sf3a1 67465
Affinity Capture-MS Mus musculus
121 CWC15  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
122 MMGT1 93380
Affinity Capture-MS Homo sapiens
123 UFL1 23376
Affinity Capture-MS Homo sapiens
124 SFSWAP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 RBFOX2 23543
Two-hybrid Homo sapiens
126 QRICH1  
Two-hybrid Homo sapiens
127 Ddx42 72047
Two-hybrid Mus musculus
128 CIT 11113
Affinity Capture-MS Homo sapiens
129 MFAP1  
Affinity Capture-MS Homo sapiens
130 DDX42 11325
Affinity Capture-MS Homo sapiens
131 SNW1 22938
Affinity Capture-MS Homo sapiens
132 KRAS 3845
Negative Genetic Homo sapiens
133 AR 367
Proximity Label-MS Homo sapiens
134 HSF2BP  
Two-hybrid Homo sapiens
135 SNRPA1 6627
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 PRMT1 3276
Affinity Capture-MS Homo sapiens
137 RANBP2 5903
Affinity Capture-MS Homo sapiens
138 EP300 2033
Affinity Capture-MS Homo sapiens
139 CDC5L 988
Affinity Capture-MS Homo sapiens
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